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  3. ADRB1

ADRB1 (Adrenoceptor beta 1)

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The Function of ADRB1

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

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Protein names

Recommended name:

Beta-1 adrenergic receptor

Alternative name(s):

Beta-1 adrenoreceptor
Beta-1 adrenoceptor

ADRB1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10787516 (ADRB1) ??
  2. RS10885531 (ADRB1) ??
  3. RS1801253 (ADRB1) ??

Top Gene-Substance Interactions

ADRB1 Interacts with These Diseases

Disease Score

Substances That Increase ADRB1

Substances Interaction Organism Category

Substances That Decrease ADRB1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Resting heart rate

     From NCBI Gene: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • Max
  • deltaCREB
  • NF-kappaB1
  • c-Myc
  • c-Fos

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Dilated cardiomyopathy
  • Salivary secretion

Molecular Function:

  • Alpha-2a Adrenergic Receptor Binding
  • Beta1-Adrenergic Receptor Activity
  • Beta-Adrenergic Receptor Activity
  • Epinephrine Binding
  • Norepinephrine Binding
  • Pdz Domain Binding
  • Protein Heterodimerization Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • Signal Transducer Activity, Downstream Of Receptor

Biological Processes:

  • Activation Of Adenylate Cyclase Activity
  • Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
  • Brown Fat Cell Differentiation
  • Cell-Cell Signaling
  • Diet Induced Thermogenesis
  • Fear Response
  • Heat Generation
  • Negative Regulation Of Multicellular Organism Growth
  • Positive Regulation Of Camp Biosynthetic Process
  • Positive Regulation Of Camp-Mediated Signaling
  • Positive Regulation Of Gtpase Activity
  • Positive Regulation Of Heart Rate By Epinephrine-Norepinephrine
  • Positive Regulation Of The Force Of Heart Contraction By Epinephrine-Norepinephrine
  • Response To Cold
  • Temperature Homeostasis
  • Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure

Drug Bank:

  • Ephedra
  • Isoetarine
  • Isoprenaline
  • Salbutamol
  • Amiodarone
  • Amitriptyline
  • Amphetamine
  • Arbutamine
  • Atenolol
  • Betaxolol
  • Bethanidine
  • Bevantolol
  • Bopindolol
  • Bupranolol
  • Cabergoline
  • Carteolol
  • Celiprolol
  • Clenbuterol
  • Desipramine
  • Dobutamine
  • Droxidopa
  • Epinephrine
  • Esmolol
  • Fenoterol
  • Labetalol
  • Loxapine
  • Mephentermine
  • Metipranolol
  • Mirtazapine
  • Nadolol
  • Norepinephrine
  • Nortriptyline
  • Olanzapine
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Pirbuterol
  • Practolol
  • Propranolol
  • Pseudoephedrine
  • Sotalol
  • Timolol
  • Vortioxetine
  • Metoprolol
  • Acebutolol
  • Alprenolol
  • Asenapine
  • Bisoprolol
  • Carvedilol
  • Dronedarone
  • Levobunolol
  • Nebivolol
  • Trimipramine
  • Phenylpropanolamine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06819| Adrb-1| ADRB1R| ADRB2| adrenergic, beta-1-, receptor| adrenergic receptor beta 1| adrenergic receptor, beta 1| adrenoceptor beta 1&#8203| B1AR| BAR1| beta1-adrenergic G-protein-coupled receptor| beta 1 adrenergic protein| beta 1-adrenergic receptor| beta-1-adrenergic receptor| Beta-1 adrenergic receptor| beta 1-adrenergic receptor beta 1-AR| Beta-1 adrenoceptor| Beta-1 adrenoreceptor| beta 1-AR| BETA1AR| Beta-4C adrenergic receptor| beta-AR| beta-T| cardiac beta adrenergic receptor| EH28_20529| G-protein-coupled hormone receptor| M91_19432| N305_14536| N306_13974| N331_08545| PAL_GLEAN10014169| RATB1AR| RHR| tripartite motif-containing 75| UY3_03757| Y1Q_013537| adrb1

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