The Function of ADRB1
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Protein names
Recommended name:
Beta-1 adrenergic receptorAlternative name(s):
Beta-1 adrenoreceptorBeta-1 adrenoceptor
- RS10885531 (ADRB1) ??
- RS1801253 (ADRB1) ??
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Top Gene-Substance Interactions
ADRB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRB1
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRB1
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Resting heart rate
From NCBI Gene: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Alpha-2a Adrenergic Receptor Binding
- Beta1-Adrenergic Receptor Activity
- Beta-Adrenergic Receptor Activity
- Epinephrine Binding
- Norepinephrine Binding
- Pdz Domain Binding
- Protein Heterodimerization Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Signal Transducer Activity, Downstream Of Receptor
Biological Processes:
- Activation Of Adenylate Cyclase Activity
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
- Brown Fat Cell Differentiation
- Cell-Cell Signaling
- Diet Induced Thermogenesis
- Fear Response
- Heat Generation
- Negative Regulation Of Multicellular Organism Growth
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Camp-Mediated Signaling
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of Heart Rate By Epinephrine-Norepinephrine
- Positive Regulation Of The Force Of Heart Contraction By Epinephrine-Norepinephrine
- Response To Cold
- Temperature Homeostasis
- Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
Drug Bank:
- Ephedra
- Isoetarine
- Isoprenaline
- Salbutamol
- Amiodarone
- Amitriptyline
- Amphetamine
- Arbutamine
- Atenolol
- Betaxolol
- Bethanidine
- Bevantolol
- Bopindolol
- Bupranolol
- Cabergoline
- Carteolol
- Celiprolol
- Clenbuterol
- Desipramine
- Dobutamine
- Droxidopa
- Epinephrine
- Esmolol
- Fenoterol
- Labetalol
- Loxapine
- Mephentermine
- Metipranolol
- Mirtazapine
- Nadolol
- Norepinephrine
- Nortriptyline
- Olanzapine
- Oxprenolol
- Penbutolol
- Pindolol
- Pirbuterol
- Practolol
- Propranolol
- Pseudoephedrine
- Sotalol
- Timolol
- Vortioxetine
- Metoprolol
- Acebutolol
- Alprenolol
- Asenapine
- Bisoprolol
- Carvedilol
- Dronedarone
- Levobunolol
- Nebivolol
- Trimipramine
- Phenylpropanolamine