Summary of ADRB1
The ADRB1 gene encodes the beta-1 adrenergic receptor [R].
This receptor is bound and activated by epinephrine (aka adrenaline) and norepinephrine (aka noradrenaline), two brain chemicals that help activate the “fight or flight” response [R].
ADRB1 increases heart rate and the strength of the heart’s contractions. Increased ADRB1 activity is associated with increased blood pressure [R, R, R].
Variants in ADRB1 have been associated with:
Low sensitivity to opioid painkillers [R]
The Function of ADRB1
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Protein names
Recommended name:
Beta-1 adrenergic receptorAlternative name(s):
Beta-1 adrenoreceptorBeta-1 adrenoceptor
- RS10787516 (ADRB1) ??
- RS10885531 (ADRB1) ??
- RS1801253 (ADRB1) ??
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Top Gene-Substance Interactions
ADRB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRB1
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRB1
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Resting heart rate
From NCBI Gene: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008] From UniProt: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Beta-Adrenergic Receptor Activity
- Beta1-Adrenergic Receptor Activity
- Signal Transducer Activity, Downstream Of Receptor
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Pdz Domain Binding
- Alpha-2a Adrenergic Receptor Binding
- Protein Heterodimerization Activity
- Epinephrine Binding
- Norepinephrine Binding
Biological Processes:
- Temperature Homeostasis
- Positive Regulation Of Heart Rate By Epinephrine-Norepinephrine
- Positive Regulation Of The Force Of Heart Contraction By Epinephrine-Norepinephrine
- Diet Induced Thermogenesis
- Vasodilation By Norepinephrine-Epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
- Activation Of Adenylate Cyclase Activity
- Cell-Cell Signaling
- Response To Cold
- Positive Regulation Of Camp Biosynthetic Process
- Heat Generation
- Negative Regulation Of Multicellular Organism Growth
- Fear Response
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of Camp-Mediated Signaling
- Brown Fat Cell Differentiation
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
Drug Bank:
- Ephedra
- Isoetarine
- Isoprenaline
- Salbutamol
- Amiodarone
- Amitriptyline
- Amphetamine
- Arbutamine
- Atenolol
- Betaxolol
- Bethanidine
- Bevantolol
- Bopindolol
- Bupranolol
- Cabergoline
- Carteolol
- Celiprolol
- Clenbuterol
- Desipramine
- Dobutamine
- Droxidopa
- Epinephrine
- Esmolol
- Fenoterol
- Labetalol
- Loxapine
- Mephentermine
- Metipranolol
- Mirtazapine
- Nadolol
- Norepinephrine
- Nortriptyline
- Olanzapine
- Oxprenolol
- Penbutolol
- Pindolol
- Pirbuterol
- Practolol
- Propranolol
- Pseudoephedrine
- Sotalol
- Timolol
- Vortioxetine
- Metoprolol
- Acebutolol
- Alprenolol
- Asenapine
- Bisoprolol
- Carvedilol
- Dronedarone
- Levobunolol
- Nebivolol
- Trimipramine
- Phenylpropanolamine