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  3. ADRA1B

ADRA1B (Adrenoceptor alpha 1B)

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The Function of ADRA1B

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

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Protein names

Recommended name:

Alpha-1B adrenergic receptor

Alternative name(s):

Alpha-1B adrenoreceptor
Alpha-1B adrenoceptor

ADRA1B SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10515807 (ADRA1B) ??
  2. RS11750092 (ADRA1B) ??

Top Gene-Substance Interactions

ADRA1B Interacts with These Diseases

Disease Score

Substances That Increase ADRA1B

Substances Interaction Organism Category

Substances That Decrease ADRA1B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Vascular smooth muscle contraction
  • Salivary secretion

Molecular Function:

  • Alpha1-Adrenergic Receptor Activity
  • Protein Heterodimerization Activity

Biological Processes:

  • Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
  • Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
  • Cell-Cell Signaling
  • Cell Proliferation
  • Glucose Homeostasis
  • G-Protein Coupled Receptor Signaling Pathway
  • Intracellular Signal Transduction
  • Multicellular Organism Development
  • Norepinephrine-Epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
  • Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Smooth Muscle Contraction
  • Positive Regulation Of Vasoconstriction
  • Regulation Of Cardiac Muscle Contraction

Drug Bank:

  • Ergoloid Mesylate
  • Lisdexamfetamine
  • Paliperidone
  • Alfuzosin
  • Amitriptyline
  • Amoxapine
  • Amphetamine
  • Aripiprazole
  • Brexpiprazole
  • Bromocriptine
  • Carvedilol
  • Chlorpromazine
  • Clonidine
  • Clozapine
  • Dapiprazole
  • Dextroamphetamine
  • Doxazosin
  • Doxepin
  • Dronedarone
  • Droxidopa
  • Ergotamine
  • Fenoldopam
  • Imipramine
  • Labetalol
  • Maprotiline
  • Mephentermine
  • Methotrimeprazine
  • Methoxamine
  • Midodrine
  • Mirtazapine
  • Modafinil
  • Nefazodone
  • Norepinephrine
  • Nortriptyline
  • Olanzapine
  • Oxymetazoline
  • Pergolide
  • Phendimetrazine
  • Phenylephrine
  • Prazosin
  • Promazine
  • Propericiazine
  • Quetiapine
  • Risperidone
  • Sertindole
  • Silodosin
  • Terazosin
  • Thioproperazine
  • Thioridazine
  • Trimipramine
  • Xylometazoline
  • Ziprasidone
  • Acepromazine
  • Cabergoline
  • Desipramine
  • Epinephrine
  • Loxapine
  • Mianserin
  • Nicardipine
  • Phenoxybenzamine
  • Propiomazine
  • Tamsulosin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| [a]1b| A306_14614| adra1| adrenergic, alpha-1B-, receptor| Adrenergic alpha 1B- receptor| adrenergic receptor, alpha 1b| alpha1B-adrenergic receptor| Alpha-1B adrenergic receptor| alpha 1b adrenoceptor| alpha-1B adrenoceptor| alpha-1B adrenoreceptor| alpha1bar| alpha-1D adrenoreceptor| AS27_11873| AS28_10283| I79_008739| M91_05171| M959_08297| MDA_GLEAN10025737| N300_13074| N301_05015| N302_05381| N303_08868| N305_05815| N306_14471| N307_13817| N308_09099| N309_12314| N310_10478| N312_12928| N320_02227| N321_03885| N322_12403| N324_05910| N325_01340| N326_09554| N327_09548| N329_02506| N330_12218| N331_10761| N332_05288| N333_08839| N334_13943| N335_03889| N340_05859| N341_11615| PAL_GLEAN10018832| PANDA_000313| RDC5| UY3_04633| Y1Q_028934| Y956_14113| Z169_04296| adra1b

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