The Function of ADRA1B
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
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Protein names
Recommended name:
Alpha-1B adrenergic receptorAlternative name(s):
Alpha-1B adrenoreceptorAlpha-1B adrenoceptor
- RS10515807 (ADRA1B) ??
- RS11750092 (ADRA1B) ??
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Top Gene-Substance Interactions
ADRA1B Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRA1B
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRA1B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Cell-Cell Signaling
- Cell Proliferation
- Glucose Homeostasis
- G-Protein Coupled Receptor Signaling Pathway
- Intracellular Signal Transduction
- Multicellular Organism Development
- Norepinephrine-Epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Vasoconstriction
- Regulation Of Cardiac Muscle Contraction
Drug Bank:
- Ergoloid Mesylate
- Lisdexamfetamine
- Paliperidone
- Alfuzosin
- Amitriptyline
- Amoxapine
- Amphetamine
- Aripiprazole
- Brexpiprazole
- Bromocriptine
- Carvedilol
- Chlorpromazine
- Clonidine
- Clozapine
- Dapiprazole
- Dextroamphetamine
- Doxazosin
- Doxepin
- Dronedarone
- Droxidopa
- Ergotamine
- Fenoldopam
- Imipramine
- Labetalol
- Maprotiline
- Mephentermine
- Methotrimeprazine
- Methoxamine
- Midodrine
- Mirtazapine
- Modafinil
- Nefazodone
- Norepinephrine
- Nortriptyline
- Olanzapine
- Oxymetazoline
- Pergolide
- Phendimetrazine
- Phenylephrine
- Prazosin
- Promazine
- Propericiazine
- Quetiapine
- Risperidone
- Sertindole
- Silodosin
- Terazosin
- Thioproperazine
- Thioridazine
- Trimipramine
- Xylometazoline
- Ziprasidone
- Acepromazine
- Cabergoline
- Desipramine
- Epinephrine
- Loxapine
- Mianserin
- Nicardipine
- Phenoxybenzamine
- Propiomazine
- Tamsulosin