Summary of ADRA1A
The ADRA1A gene encodes adrenoreceptor alpha 1A (or the alpha 1A adrenergic receptor) [R].
As its name suggests, ADRA1A binds to epinephrine (adrenaline) and norepinephrine (noradrenaline). Once activated, it promotes the growth and proliferation of cells [R, R].
Variants in ADRA1A have been linked to [R, R, R, R]:
- Chronic fatigue syndrome/myalgic encephalomyelitis (CFE/ME)
- ADHD
- Multiple sclerosis
- Depression
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Protein names
Recommended name:
Alpha-1D adrenergic receptorAlternative name(s):
Alpha-1A adrenergic receptorAlpha-1D adrenoreceptor
Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a
- RS1048101 (ADRA1A) ??
- RS13278849 (ADRA1A) ??
- RS4732957 (ADRA1A) ??
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Top Gene-Substance Interactions
ADRA1A Interacts with These Diseases
| Disease | Score |
Substances That Increase ADRA1A
| Substances | Interaction | Organism | Category |
Substances That Decrease ADRA1A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Gene Pathways:
Molecular Function:
Biological Processes:
- Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure
- Norepinephrine-Epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
- Positive Regulation Of Heart Rate By Epinephrine-Norepinephrine
- Positive Regulation Of The Force Of Heart Contraction By Epinephrine-Norepinephrine
- Positive Regulation Of Systemic Arterial Blood Pressure
- Dna Metabolic Process
- Apoptotic Process
- Smooth Muscle Contraction
- Signal Transduction
- G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Activation Of Phospholipase C Activity
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Cell-Cell Signaling
- Multicellular Organism Development
- Adult Heart Development
- Aging
- Cell Proliferation
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Response To Hormone
- Cell Growth
- Positive Regulation Of Synaptic Transmission, Gabaergic
- Negative Regulation Of Rho Protein Signal Transduction
- Organ Growth
- Intracellular Signal Transduction
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Action Potential
- Positive Regulation Of Vasoconstriction
- Positive Regulation Of Smooth Muscle Contraction
- Micturition
- Calcium Ion Transport Into Cytosol
- Positive Regulation Of Cardiac Muscle Contraction
- Positive Regulation Of Erk1 And Erk2 Cascade
- Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
- Positive Regulation Of Protein Kinase C Signaling
- Pilomotor Reflex
Drug Bank:
- Doxepin
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- Amitriptyline
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- Norepinephrine
- Nortriptyline
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- Prazosin
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