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  3. ADRA1A

ADRA1A (Adrenoceptor alpha 1A)

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The Function of ADRA1A

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

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Protein names

Recommended name:

Alpha-1D adrenergic receptor

Alternative name(s):

Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a

ADRA1A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1048101 (ADRA1A) ??
  2. RS13278849 (ADRA1A) ??
  3. RS4732957 (ADRA1A) ??

Top Gene-Substance Interactions

ADRA1A Interacts with These Diseases

Disease Score

Substances That Increase ADRA1A

Substances Interaction Organism Category

Substances That Decrease ADRA1A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Fos

Tissue specificity:

Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Vascular smooth muscle contraction
  • Salivary secretion

Molecular Function:

  • Alpha1-Adrenergic Receptor Activity
  • Protein Heterodimerization Activity

Biological Processes:

  • Activation Of Phospholipase C Activity
  • Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway
  • Adult Heart Development
  • Aging
  • Apoptotic Process
  • Calcium Ion Transport Into Cytosol
  • Cell-Cell Signaling
  • Cell Growth
  • G-Protein Coupled Receptor Signaling Pathway
  • Intracellular Signal Transduction
  • Micturition
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure
  • Negative Regulation Of Rho Protein Signal Transduction
  • Norepinephrine-Epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
  • Organ Growth
  • Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Pilomotor Reflex
  • Positive Regulation Of Action Potential
  • Positive Regulation Of Cardiac Muscle Contraction
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Heart Rate By Epinephrine-Norepinephrine
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Protein Kinase C Signaling
  • Positive Regulation Of Smooth Muscle Contraction
  • Positive Regulation Of Synaptic Transmission, Gabaergic
  • Positive Regulation Of Systemic Arterial Blood Pressure
  • Positive Regulation Of The Force Of Heart Contraction By Epinephrine-Norepinephrine
  • Positive Regulation Of Vasoconstriction
  • Response To Hormone
  • Signal Transduction
  • Smooth Muscle Contraction
  • Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
  • Cell Proliferation
  • Dna Metabolic Process
  • Multicellular Organism Development
  • Positive Regulation Of Cell Proliferation

Drug Bank:

  • Doxepin
  • Alfuzosin
  • Amitriptyline
  • Amoxapine
  • Apraclonidine
  • Aripiprazole
  • Asenapine
  • Benzphetamine
  • Bevantolol
  • Bromocriptine
  • Cabergoline
  • Chlorpromazine
  • Citalopram
  • Clonidine
  • Clozapine
  • Dapiprazole
  • Dextroamphetamine
  • Dipivefrin
  • Doxazosin
  • Ergoloid Mesylate
  • Flupentixol
  • Levonordefrin
  • Paliperidone
  • Tetryzoline
  • Zuclopenthixol
  • Droperidol
  • Ephedrine
  • Epinastine
  • Epinephrine
  • Ergonovine
  • Escitalopram
  • Fenoldopam
  • Iloperidone
  • Imipramine
  • Isometheptene
  • Labetalol
  • Maprotiline
  • Mephentermine
  • Metaraminol
  • Methotrimeprazine
  • Mianserin
  • Midodrine
  • Mirtazapine
  • Naphazoline
  • Nicardipine
  • Nicergoline
  • Norepinephrine
  • Nortriptyline
  • Olanzapine
  • Oxymetazoline
  • Phendimetrazine
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine
  • Prazosin
  • Promethazine
  • Propiomazine
  • Pseudoephedrine
  • Quetiapine
  • Risperidone
  • Sertindole
  • Tamsulosin
  • Terazosin
  • Thioproperazine
  • Thioridazine
  • Tolazoline
  • Trazodone
  • Trimipramine
  • Xylometazoline
  • Ziprasidone
  • Phenylpropanolamine
  • Acepromazine
  • Amphetamine
  • Carvedilol
  • Desipramine
  • Dronedarone
  • Droxidopa
  • Ergotamine
  • Loxapine
  • Methoxamine
  • Nefazodone
  • Pergolide
  • Promazine
  • Silodosin
  • Trifluoperazine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ADRA1C| ADRA1L1| adrenergic, alpha 1A, receptor| adrenergic, alpha-1A-, receptor| adrenergic alpha 1c receptor| adrenergic receptor alpha 1a| adrenergic receptor, alpha 1a| adrenergic receptor alpha-1A| adrenergic receptor, alpha 1c| adrenergic receptor alpha 1c subtype| ALPHA-1A| alpha-1A adrenergic receptor| alpha-1A-adrenergic receptor isoform 1 isoform 1-like protein| alpha-1A adrenergic receptor-like protein| alpha 1a-adrenoceptor| alpha-1A adrenoceptor| alpha-1A adrenoceptor variant 3a| alpha-1A adrenoreceptor| ALPHA1AAR| alpha-1C adrenergic receptor| AS27_03186| AS28_08920| CB1_002524022| D623_10002455| EGK_18793| G protein coupled receptor| H920_00488| M91_04138| M959_08954| N300_11722| N301_09510| N302_03396| N303_01103| N305_08816| N306_07575| N307_07586| N308_01111| N309_04816| N310_07231| N311_06578| N312_02438| N320_11597| N322_12024| N324_02683| N325_11992| N326_02272| N327_10786| N328_03655| N329_08827| N330_01043| N331_11530| N332_07472| N333_03922| N334_03087| N335_12277| N336_08849| N339_05532| N340_01825| PAL_GLEAN10012328| PANDA_002361| TREES_T100010823| UY3_12379| Y1Q_004330| Y956_03230| Z169_05153| adra1a

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