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  3. ADORA2A

ADORA2A (Adenosine A2a receptor)

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Summary of ADORA2A

This gene encodes proteins that respond to extracellular cues and activate intracellular signal transduction pathways. The proteins play an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep (R).

It is associated with inflammatory diseases and neurodegenerative disorders (R).

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The Function of ADORA2A

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Protein names

Recommended name:

Adenosine receptor A2a

ADORA2A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2236624 (ADORA2A) ??
  2. RS2267076 (ADORA2A) ??
  3. RS2298383 (ADORA2A) ??
  4. RS4822489 (ADORA2A) ??
  5. RS5751876 (ADORA2A) ??

Top Gene-Substance Interactions

ADORA2A Interacts with These Diseases

Disease Score

Substances That Increase ADORA2A

Substances Interaction Organism Category

Substances That Decrease ADORA2A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • Egr-1
  • NF-kappaB1

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Vascular smooth muscle contraction

Molecular Function:

  • Enzyme Binding
  • G-Protein Coupled Adenosine Receptor Activity
  • Identical Protein Binding

Biological Processes:

  • Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
  • Apoptotic Process
  • Blood Circulation
  • Blood Coagulation
  • Camp Biosynthetic Process
  • Cell-Cell Signaling
  • Cellular Defense Response
  • Cellular Protein Metabolic Process
  • Central Nervous System Development
  • Inflammatory Response
  • Phagocytosis
  • Positive Regulation Of Adenylate Cyclase Activity Involved In G-Protein Coupled Receptor Signaling Pathway
  • Sensory Perception

Drug Bank:

  • Oxtriphylline
  • Caffeine
  • Dyphylline
  • Enprofylline
  • Mefloquine
  • Pentoxifylline
  • Regadenoson
  • Theobromine
  • Adenosine
  • Defibrotide
  • Theophylline
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A2AAR| A2ar| A306_02521| AA2AR| ADENO| Adenosine A2a-receptor| adenosine receptor A2a| adenosine receptor A2a long isoform| adenosine receptor subtype A2a| ADORA2| Adora2l1| AS27_08984| AS28_08510| CB1_000302041| EGK_02873| GW7_18907| H920_14906| M91_17214| M959_05956| MDA_GLEAN10012776| N300_08232| N301_16780| N302_15499| N303_08765| N305_04661| N306_04878| N307_14093| N308_10020| N309_05150| N310_10241| N311_10095| N312_10961| N321_12138| N322_08917| N325_07290| N326_01466| N327_09783| N328_07976| N332_02272| N333_07898| N336_04463| N340_04335| PANDA_014549| RDC8| TREES_T100005555| UY3_10726| Y1Q_004154| Y956_15742| Z169_10705| adora2a

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