Summary of ADORA2A
This gene encodes proteins that respond to extracellular cues and activate intracellular signal transduction pathways. The proteins play an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep (R).
It is associated with inflammatory diseases and neurodegenerative disorders (R).
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The Function of ADORA2A
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Protein names
Recommended name:
Adenosine receptor A2a- RS2236624 (ADORA2A) ??
- RS2267076 (ADORA2A) ??
- RS2298383 (ADORA2A) ??
- RS4822489 (ADORA2A) ??
- RS5751876 (ADORA2A) ??
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Top Gene-Substance Interactions
ADORA2A Interacts with These Diseases
| Disease | Score |
Substances That Increase ADORA2A
| Substances | Interaction | Organism | Category |
Substances That Decrease ADORA2A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Apoptotic Process
- Blood Circulation
- Blood Coagulation
- Camp Biosynthetic Process
- Cell-Cell Signaling
- Cellular Defense Response
- Cellular Protein Metabolic Process
- Central Nervous System Development
- Inflammatory Response
- Phagocytosis
- Positive Regulation Of Adenylate Cyclase Activity Involved In G-Protein Coupled Receptor Signaling Pathway
- Sensory Perception
Drug Bank:
- Oxtriphylline
- Caffeine
- Dyphylline
- Enprofylline
- Mefloquine
- Pentoxifylline
- Regadenoson
- Theobromine
- Adenosine
- Defibrotide
- Theophylline