Summary of ADORA2A
The ADORA2A gene encodes adenosine receptor A2A [R].
This receptor binds to adenosine in a region of the brain called the nucleus accumbens. This brain region is best known as the main location of dopamine signalling [R].
When adenosine binds to the A2A receptor, dopamine becomes less able to bind to its D2 receptor. As a result, higher ADORA2A gene expression results in more dopamine production [R, R].
Adenosine receptor A2A also has an effect on heartbeat rhythm, blood flow, immune function, pain perception, and the sleep cycle [R].
Variants in the ADORA2A gene have been associated with heart and brain disorders, including:
- Depression [R]
- Anxiety disorders [R]
- Schizophrenia [R]
- High blood pressure [R]
- Caffeine consumption [R]
- Heart failure [R]
Protein names
Recommended name:
Adenosine receptor A2a- RS2236624 (ADORA2A) ??
- RS2267076 (ADORA2A) ??
- RS2298383 (ADORA2A) ??
- RS4822489 (ADORA2A) ??
- RS5751876 (ADORA2A) ??
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Top Gene-Substance Interactions
ADORA2A Interacts with These Diseases
| Disease | Score |
Substances That Increase ADORA2A
| Substances | Interaction | Organism | Category |
Substances That Decrease ADORA2A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Apoptotic Process
- Blood Circulation
- Blood Coagulation
- Camp Biosynthetic Process
- Cell-Cell Signaling
- Cellular Defense Response
- Cellular Protein Metabolic Process
- Central Nervous System Development
- Inflammatory Response
- Phagocytosis
- Positive Regulation Of Adenylate Cyclase Activity Involved In G-Protein Coupled Receptor Signaling Pathway
- Sensory Perception
Drug Bank:
- Oxtriphylline
- Caffeine
- Dyphylline
- Enprofylline
- Mefloquine
- Pentoxifylline
- Regadenoson
- Theobromine
- Adenosine
- Defibrotide
- Theophylline