The Function of ADNP
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
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Protein names
Recommended name:
Activity-dependent neuroprotector homeobox proteinAlternative name(s):
Activity-dependent neuroprotective protein- RS12480328 (ADNP) ??
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Top Gene-Substance Interactions
Substances That Increase ADNP
| Substances | Interaction | Organism | Category |
Substances That Decrease ADNP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.
Molecular Function:
Biological Processes:
- Activation Of Protein Kinase Activity
- Cellular Response To Extracellular Stimulus
- Estrous Cycle
- Negative Regulation Of Gene Expression
- Negative Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Synaptic Transmission
- Nitric Oxide Homeostasis
- Positive Regulation Of Axon Extension
- Positive Regulation Of Cgmp Biosynthetic Process
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Synapse Assembly
- Regulation Of Protein Adp-Ribosylation
- Regulation Of Transcription, Dna-Templated
- Response To Carbohydrate
- Response To Inorganic Substance
- Short-Term Memory
- Transcription, Dna-Templated