The Function of ADM
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Protein names
Recommended name:
ADM [Cleaved into: AdrenomedullinShort name:
AMAlternative name(s):
ProAM N-terminal 20 peptidePAMP
ProAM-N20
- RS11042725 (ADM) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ADM Interacts with These Diseases
| Disease | Score |
Substances That Increase ADM
| Substances | Interaction | Organism | Category |
Substances That Decrease ADM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
Gene Pathways:
Molecular Function:
Biological Processes:
- Aging
- Androgen Metabolic Process
- Animal Organ Regeneration
- Antibacterial Humoral Response
- Blood Circulation
- Branching Involved In Labyrinthine Layer Morphogenesis
- Camp Biosynthetic Process
- Camp-Mediated Signaling
- Cell-Cell Signaling
- Defense Response To Gram-Negative Bacterium
- Defense Response To Gram-Positive Bacterium
- Developmental Growth
- Female Pregnancy
- G-Protein Coupled Receptor Internalization
- Heart Development
- Hormone Secretion
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Vascular Permeability
- Negative Regulation Of Vasoconstriction
- Neural Tube Closure
- Neuron Projection Regeneration
- Odontogenesis Of Dentin-Containing Tooth
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Heart Rate
- Positive Regulation Of Vasculogenesis
- Positive Regulation Of Vasodilation
- Progesterone Biosynthetic Process
- Receptor Internalization
- Regulation Of The Force Of Heart Contraction
- Response To Cold
- Response To Glucocorticoid
- Response To Hypoxia
- Response To Insulin
- Response To Lipopolysaccharide
- Response To Starvation
- Response To Wounding
- Signal Transduction
- Spongiotrophoblast Layer Development
- Vascular Smooth Muscle Cell Development
- Vasculogenesis