The Function of ADM
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Protein names
Recommended name:
ADM [Cleaved into: AdrenomedullinShort name:
AMAlternative name(s):
ProAM N-terminal 20 peptidePAMP
ProAM-N20
- RS11042725 (ADM) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ADM Interacts with These Diseases
| Disease | Score |
Substances That Increase ADM
| Substances | Interaction | Organism | Category |
Substances That Decrease ADM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
Gene Pathways:
Molecular Function:
Biological Processes:
- Vasculogenesis
- Response To Hypoxia
- Neural Tube Closure
- Regulation Of The Force Of Heart Contraction
- G-Protein Coupled Receptor Internalization
- Camp Biosynthetic Process
- Progesterone Biosynthetic Process
- Signal Transduction
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Cell-Cell Signaling
- Heart Development
- Female Pregnancy
- Aging
- Blood Circulation
- Androgen Metabolic Process
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Response To Cold
- Response To Wounding
- Positive Regulation Of Heart Rate
- Antibacterial Humoral Response
- Camp-Mediated Signaling
- Positive Regulation Of Camp Biosynthetic Process
- Animal Organ Regeneration
- Neuron Projection Regeneration
- Receptor Internalization
- Response To Lipopolysaccharide
- Response To Insulin
- Odontogenesis Of Dentin-Containing Tooth
- Response To Starvation
- Positive Regulation Of Apoptotic Process
- Negative Regulation Of Vascular Permeability
- Positive Regulation Of Angiogenesis
- Negative Regulation Of Vasoconstriction
- Positive Regulation Of Vasodilation
- Hormone Secretion
- Developmental Growth
- Defense Response To Gram-Negative Bacterium
- Defense Response To Gram-Positive Bacterium
- Response To Glucocorticoid
- Branching Involved In Labyrinthine Layer Morphogenesis
- Spongiotrophoblast Layer Development
- Vascular Smooth Muscle Cell Development
- Positive Regulation Of Vasculogenesis