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  3. ADK

ADK (Adenosine kinase)

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The Function of ADK

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

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Protein names

Recommended name:

Adenosine kinase

Short name:

AK

Alternative name(s):

Adenosine 5'-phosphotransferase

ADK SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12220238 (ADK) ??
  2. RS17747401 (ADK) ??
  3. RS7924176 (ADK) ??

Top Gene-Substance Interactions

ADK Interacts with These Diseases

Disease Score

Substances That Increase ADK

Substances Interaction Organism Category

Substances That Decrease ADK

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Hypermethioninemia due to adenosine kinase deficiencyFrom UniProt: Hypermethioninemia due to adenosine kinase deficiency (HMAKD): A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal. [MIM:614300]

     From NCBI Gene: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] From UniProt: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-alpha

Tissue specificity:

Widely expressed. Highest level in placenta, liver, muscle and kidney.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Purine metabolism

Cofactor:

Binds 3 Mg(2+) ions per subunit.

Molecular Function:

  • Adenosine Kinase Activity
  • Atp Binding
  • Metal Ion Binding
  • Poly(A) Rna Binding

Biological Processes:

  • Amp Salvage
  • Datp Biosynthetic Process
  • Purine-Containing Compound Salvage
  • Ribonucleoside Monophosphate Biosynthetic Process
  • Adenosine Metabolic Process
  • Circadian Regulation Of Gene Expression
  • Positive Regulation Of Cardiac Muscle Hypertrophy
  • Positive Regulation Of T Cell Proliferation
  • Type B Pancreatic Cell Proliferation

Drug Bank:

  • Adenosine Triphosphate
  • Abacavir
  • Adenosine
  • Adenosine Monophosphate
  • Ribavirin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12490| adenosine 5'-phosphotransferase| adenosine kinase a| adenosine kinase-like protein| adenosine kinase (short isoform)-like protein| Ak| AS27_02517| AS28_05961| D623_10029139| H920_01655| I79_002182| M959_03540| MDA_GLEAN10020904| N300_11813| N301_04266| N302_07438| N303_09271| N305_02716| N306_10544| N307_06059| N308_00246| N309_06603| N310_07720| N311_12273| N312_08958| N320_11902| N329_03363| N331_00623| N333_11660| N334_13942| N335_11896| N339_09795| N341_05887| PAL_GLEAN10020482| testicular tissue protein Li 14| UY3_04873| Y1Q_000602| Y956_09059| Z169_12727| adk

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