The Function of ADK
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Protein names
Recommended name:
Adenosine kinaseShort name:
AKAlternative name(s):
Adenosine 5'-phosphotransferase- RS12220238 (ADK) ??
- RS17747401 (ADK) ??
- RS7924176 (ADK) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ADK Interacts with These Diseases
Disease | Score |
Substances That Increase ADK
Substances | Interaction | Organism | Category |
Substances That Decrease ADK
Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Hypermethioninemia due to adenosine kinase deficiencyFrom UniProt: Hypermethioninemia due to adenosine kinase deficiency (HMAKD): A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal. [MIM:614300]
From NCBI Gene: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] From UniProt: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Gene Pathways:
Cofactor:
Binds 3 Mg(2+) ions per subunit.
Molecular Function:
Biological Processes:
- Amp Salvage
- Datp Biosynthetic Process
- Purine-Containing Compound Salvage
- Ribonucleoside Monophosphate Biosynthetic Process
- Adenosine Metabolic Process
- Circadian Regulation Of Gene Expression
- Positive Regulation Of Cardiac Muscle Hypertrophy
- Positive Regulation Of T Cell Proliferation
- Type B Pancreatic Cell Proliferation
Drug Bank:
- Adenosine Triphosphate
- Abacavir
- Adenosine
- Adenosine Monophosphate
- Ribavirin