The Function of ADIPOR1
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin.
Protein names
Recommended name:
Adiponectin receptor protein 1Alternative name(s):
Progestin and adipoQ receptor family member I- RS10753929 (ADIPOR1) ??
- RS10920531 (ADIPOR1) ??
- RS1342387 (ADIPOR1) ??
- RS6666089 (ADIPOR1) ??
- RS7539542 (ADIPOR1) ??
- RS7539625 (ADIPOR1) ??
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Top Gene-Substance Interactions
ADIPOR1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADIPOR1
| Substances | Interaction | Organism | Category |
Substances That Decrease ADIPOR1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
Gene Pathways:
Molecular Function:
Biological Processes:
- Adiponectin-Activated Signaling Pathway
- Fatty Acid Oxidation
- Glucose Homeostasis
- Hormone-Mediated Signaling Pathway
- Leptin-Mediated Signaling Pathway
- Negative Regulation Of Cell Growth
- Negative Regulation Of Epithelial Cell Migration
- Negative Regulation Of Epithelial To Mesenchymal Transition
- Negative Regulation Of Jak-Stat Cascade
- Negative Regulation Of Nik/Nf-Kappab Signaling
- Positive Regulation Of Insulin Receptor Signaling Pathway
- Positive Regulation Of Jak-Stat Cascade
- Regulation Of Glucose Metabolic Process
- Regulation Of Lipid Metabolic Process