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  3. ADH7

ADH7 (Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide)

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The Function of ADH7

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

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Protein names

Recommended name:

Alcohol dehydrogenase class 4 mu/sigma chain

Alternative name(s):

Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase

ADH7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1154460 (ADH7) ??
  2. RS148915469 (ADH7) ??
  3. RS1573496 (ADH7) ??
  4. RS284787 (ADH7) ??
  5. RS971074 (ADH7) ??

Top Gene-Substance Interactions

ADH7 Interacts with These Diseases

Disease Score

Substances That Increase ADH7

Substances Interaction Organism Category

Substances That Decrease ADH7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • C/EBPalpha
  • MRF-2
  • NF-AT4
  • NF-AT3
  • NF-AT2

Tissue specificity:

Preferentially expressed in stomach.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Fatty acid metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Glycolysis / Gluconeogenesis
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Tyrosine metabolism

Caution:

It is uncertain whether Met-1 or Met-13 is the initiator.

Cofactor:

Binds 2 Zn(2+) ions per subunit.

Molecular Function:

  • Alcohol Dehydrogenase (Nad) Activity
  • Alcohol Dehydrogenase Activity, Zinc-Dependent
  • Aldehyde Oxidase Activity
  • Ethanol Binding
  • Receptor Antagonist Activity
  • Retinol Binding
  • Retinol Dehydrogenase Activity
  • Zinc Ion Binding

Biological Processes:

  • Ethanol Catabolic Process
  • Ethanol Oxidation
  • Fatty Acid Omega-Oxidation
  • Oxidation-Reduction Process
  • Response To Bacterium
  • Response To Ethanol
  • Retinoic Acid Metabolic Process
  • Retinoid Metabolic Process
  • Retinol Metabolic Process

Drug Bank:

  • Ethanol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Adh3| alcohol dehydrogenase 4| ADH10B| Adh-3| Adh-3e| Adh3-e| Adh-3t| Adh3-t| Adh4| ADH-C2| Adt-1| Alcohol dehydrogenase 10B| alcohol dehydrogenase 3 complex| alcohol dehydrogenase 3 temporal| alcohol dehydrogenase-7| Alcohol dehydrogenase class 4 mu/sigma chain| alcohol dehydrogenase class IV mu/sigma chain| alcohol dehydrogenase VII| class IV alcohol dehydrogenase, mu or sigma subunit| class IV sigma-1 alcohol dehydrogenase| class IV sigmasigma alcohol dehydrogenase| D623_10012976| gastric alcohol dehydrogenase| I79_024885| IV ADH| MDA_GLEAN10016947| retinol dehydrogenase| TREES_T100009122| adh7

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