The Function of ADH7
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
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Protein names
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chainAlternative name(s):
Alcohol dehydrogenase class IV mu/sigma chainGastric alcohol dehydrogenase
Retinol dehydrogenase
- RS1154460 (ADH7) ??
- RS148915469 (ADH7) ??
- RS1573496 (ADH7) ??
- RS284787 (ADH7) ??
- RS971074 (ADH7) ??
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Top Gene-Substance Interactions
ADH7 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADH7
| Substances | Interaction | Organism | Category |
Substances That Decrease ADH7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Preferentially expressed in stomach.
Gene Pathways:
Caution:
It is uncertain whether Met-1 or Met-13 is the initiator.
Cofactor:
Binds 2 Zn(2+) ions per subunit.
Molecular Function:
- Alcohol Dehydrogenase (Nad) Activity
- Alcohol Dehydrogenase Activity, Zinc-Dependent
- Aldehyde Oxidase Activity
- Ethanol Binding
- Receptor Antagonist Activity
- Retinol Binding
- Retinol Dehydrogenase Activity
- Zinc Ion Binding
Biological Processes:
- Ethanol Catabolic Process
- Ethanol Oxidation
- Fatty Acid Omega-Oxidation
- Oxidation-Reduction Process
- Response To Bacterium
- Response To Ethanol
- Retinoic Acid Metabolic Process
- Retinoid Metabolic Process
- Retinol Metabolic Process