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  3. ADH4

ADH4 (Alcohol dehydrogenase 4 (class II), pi polypeptide)

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Protein names

Recommended name:

Alcohol dehydrogenase 4

Alternative name(s):

Alcohol dehydrogenase class II pi chain

ADH4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1042364 (ADH4) ??
  2. RS1126671 (ADH4) ??
  3. RS3805322 (ADH4) ??

Top Gene-Substance Interactions

ADH4 Interacts with These Diseases

Disease Score

Substances That Increase ADH4

Substances Interaction Organism Category

Substances That Decrease ADH4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • HNF-1A
  • HNF-1
  • NF-AT4
  • NF-AT3
  • NF-AT2

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Fatty acid metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Glycolysis / Gluconeogenesis
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Tyrosine metabolism

Cofactor:

Binds 2 Zn(2+) ions per subunit.

Molecular Function:

  • Alcohol Dehydrogenase (Nad) Activity
  • Alcohol Dehydrogenase Activity, Zinc-Dependent
  • Alditol:Nadp+ 1-Oxidoreductase Activity
  • All-Trans Retinal Binding
  • Benzaldehyde Dehydrogenase Activity
  • Ethanol Binding
  • Nad Binding
  • Nadph:Quinone Reductase Activity
  • Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Nad Or Nadp As Acceptor
  • Retinol Binding
  • Retinol Dehydrogenase Activity
  • Zinc Ion Binding

Biological Processes:

  • Alcohol Catabolic Process
  • Alcohol Metabolic Process
  • Cellular Aldehyde Metabolic Process
  • Ethanol Oxidation
  • Quinone Metabolic Process
  • Retinoid Metabolic Process
  • Retinol Metabolic Process

Drug Bank:

  • Ethanol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| aldehyde reductase| ADH-1| Ac1002| Adh2| ADH-2| Alcohol dehydrogenase 2| alcohol dehydrogenase 4| alcohol dehydrogenase class II| alcohol dehydrogenase class II pi chain| alcohol dehydrogenase class IV| alcohol dehydrogenase II| class II alcohol dehydrogenase 4 pi subunit| class II alcohol dehydrogenase, pi subunit| class II type ADH| epididymis secretory protein Li 4| HEL-S-4| M91_09095| PAL_GLEAN10010947| PANDA_010133| XELAEV_18005745mg| adh4

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