The Function of ADD1
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
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Protein names
Recommended name:
Alpha-adducinAlternative name(s):
Erythrocyte adducin subunit alpha- RS17833172 (ADD1) ??
- RS4961 (ADD1) ??
- RS4963 (ADD1) ??
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Top Gene-Substance Interactions
Substances That Increase ADD1
| Substances | Interaction | Organism | Category |
Substances That Decrease ADD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Gene Pathways:
Molecular Function:
- Actin Binding
- Actin Filament Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
- Poly(A) Rna Binding
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
- Spectrin Binding
- Structural Molecule Activity
- Transcription Factor Binding
Biological Processes:
- Actin Cytoskeleton Organization
- Actin Filament Bundle Assembly
- Barbed-End Actin Filament Capping
- Cell Morphogenesis
- Cell Volume Homeostasis
- Erythrocyte Differentiation
- Hemoglobin Metabolic Process
- Homeostasis Of Number Of Cells Within A Tissue
- In Utero Embryonic Development
- Ire1-Mediated Unfolded Protein Response
- Multicellular Organism Growth
- Transmembrane Transport