Summary of ADD1
The ADD1 gene encodes adducin 1 or alpha-adducin, part of a larger protein simply called adducin [R, R].
Adducin is part of the cytoskeleton, the structural support system of the cell. It mostly maintains the shape and structure of the cell membrane. Alterations to adducin may cause a wide variety of health problems, including cancer [R, R].
Variants in the ADD1 gene have been linked to [R, R, R, R, R, R]:
- High blood pressure
- Tinnitus
- Schizophrenia
- Colorectal cancer
- Cancer after toxin exposure
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Alpha-adducinAlternative name(s):
Erythrocyte adducin subunit alpha- RS17833172 (ADD1) ??
- RS4961 (ADD1) ??
- RS4963 (ADD1) ??
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Top Gene-Substance Interactions
Substances That Increase ADD1
| Substances | Interaction | Organism | Category |
Substances That Decrease ADD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Gene Pathways:
Molecular Function:
- Actin Binding
- Structural Molecule Activity
- Transcription Factor Binding
- Spectrin Binding
- Protein Homodimerization Activity
- Poly(A) Rna Binding
- Protein Heterodimerization Activity
- Actin Filament Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Cell Morphogenesis
- In Utero Embryonic Development
- Cell Volume Homeostasis
- Hemoglobin Metabolic Process
- Actin Cytoskeleton Organization
- Erythrocyte Differentiation
- Multicellular Organism Growth
- Ire1-Mediated Unfolded Protein Response
- Homeostasis Of Number Of Cells Within A Tissue
- Barbed-End Actin Filament Capping
- Actin Filament Bundle Assembly
- Transmembrane Transport