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  3. ADD1

ADD1 (Adducin 1)

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The Function of ADD1

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

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Protein names

Recommended name:

Alpha-adducin

Alternative name(s):

Erythrocyte adducin subunit alpha

ADD1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17833172 (ADD1) ??
  2. RS4961 (ADD1) ??
  3. RS4963 (ADD1) ??

Top Gene-Substance Interactions

Substances That Increase ADD1

Substances Interaction Organism Category

Substances That Decrease ADD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Gene Pathways:

  • Metabolism of proteins
  • Apoptosis

Molecular Function:

  • Actin Binding
  • Actin Filament Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Poly(A) Rna Binding
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity
  • Spectrin Binding
  • Structural Molecule Activity
  • Transcription Factor Binding

Biological Processes:

  • Actin Cytoskeleton Organization
  • Actin Filament Bundle Assembly
  • Barbed-End Actin Filament Capping
  • Cell Morphogenesis
  • Cell Volume Homeostasis
  • Erythrocyte Differentiation
  • Hemoglobin Metabolic Process
  • Homeostasis Of Number Of Cells Within A Tissue
  • In Utero Embryonic Development
  • Ire1-Mediated Unfolded Protein Response
  • Multicellular Organism Growth
  • Transmembrane Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ADD1-PA| ADD1-PB| ADD1-PE| add2| adda| ADD domain-containing protein 1| adducin 1 (alpha)| adducin 2 (beta)| adipocyte determination and differentiation factor-1| alpha-ADD| alpha-adducin| Anapl_00081| AS27_15302| AS28_13107| BEST:LD29214| bZ1H20.1| CB1_000117018| CG8290 gene product from transcript CG8290-RA| CG8290-PA| CG8290-PB| CG8290-PE| dADD1| Dmel_CG8290| EGK_00038| erythrocyte adducin alpha subunit| erythrocyte adducin subunit alpha| GW7_18939| H920_12854| LD29214| M91_04540| M959_01451| MDA_GLEAN10010369| N300_01805| N301_16018| N302_15110| N303_09381| N306_14313| N307_06658| N308_14025| N309_09656| N310_04859| N311_07610| N312_02979| N320_00150| N324_09419| N325_04047| N326_08417| N327_02480| N328_00305| N329_05473| N330_12029| N331_01830| N332_14340| N333_06747| N334_03149| N335_11839| N341_06329| PAL_GLEAN10022890| PANDA_004687| TREES_T100000772| UY3_07264| Y1Q_026285| Y956_04834| Z169_00451| add1

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