Summary of ADCY2
ADCY2 encodes a protein that is a membrane-associated enzyme. It catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP) (R).
The Function of ADCY2
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors.
Protein names
Recommended name:
Adenylate cyclase type 2Alternative name(s):
ATP pyrophosphate-lyase 2Adenylate cyclase type II
Adenylyl cyclase 2
- RS10038196 (ADCY2) ??
- RS13166360 (ADCY2) ??
- RS13174252 (ADCY2) ??
- RS17826816 (ADCY2) ??
- RS1846681 (ADCY2) ??
- RS1946468 (ADCY2) ??
- RS2914295 (ADCY2) ??
- RS326155 (ADCY2) ??
- RS4702473 (ADCY2) ??
- RS4702484 (ADCY2) ??
- RS6880956 (ADCY2) ??
- RS78277363 (ADCY2) ??
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Top Gene-Substance Interactions
ADCY2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADCY2
| Substances | Interaction | Organism | Category |
Substances That Decrease ADCY2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.
Gene Pathways:
- Metabolism
- Disease
- Immune System
- Signal Transduction
- Melanogenesis
- Calcium signaling pathway
- Bile secretion
- Chemokine signaling pathway
- Pancreatic secretion
- Vascular smooth muscle contraction
- Purine metabolism
- Dilated cardiomyopathy
- Gastric acid secretion
- Glutamatergic synapse
- Neuronal System
- Oocyte meiosis
- Progesterone-mediated oocyte maturation
- Transmembrane transport of small molecules
- GnRH signaling pathway
- Salivary secretion
Enzyme Regulation:
Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme.
Cofactor:
Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Molecular Function:
- Adenylate Cyclase Activity
- Adenylate Cyclase Binding
- Atp Binding
- Magnesium Ion Binding
- Manganese Ion Binding
- Protein Heterodimerization Activity
Biological Processes:
- Activation Of Adenylate Cyclase Activity
- Activation Of Protein Kinase A Activity
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Camp Biosynthetic Process
- Camp-Mediated Signaling
- Cellular Response To Forskolin
- Cellular Response To Glucagon Stimulus
- Renal Water Homeostasis