The Function of ADAMTS9
Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
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Protein names
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 9Short name:
ADAM-TS9Alternative name(s):
ADAM-TS 9ADAMTS-9
- RS4607103 (ADAMTS9) ??
- RS80311637 (ADAMTS9) ??
- RS9866261 (ADAMTS9) ??
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Top Gene-Substance Interactions
Substances That Increase ADAMTS9
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Substances That Decrease ADAMTS9
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.
Gene Pathways:
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
Biological Processes:
- Proteolysis
- Glycoprotein Catabolic Process
- Multicellular Organism Development
- Protein Transport
- Vesicle-Mediated Transport
- Positive Regulation Of Melanocyte Differentiation