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  3. ADAMTS9

ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9)

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The Function of ADAMTS9

Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

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Protein names

Recommended name:

A disintegrin and metalloproteinase with thrombospondin motifs 9

Short name:

ADAM-TS9

Alternative name(s):

ADAM-TS 9
ADAMTS-9

ADAMTS9 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS80311637 (ADAMTS9) ??
  2. RS9866261 (ADAMTS9) ??

Top Gene-Substance Interactions

Substances That Increase ADAMTS9

Substances Interaction Organism Category

Substances That Decrease ADAMTS9

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • Nkx2-5
  • HNF-4alpha1
  • Cdc5
  • Bach1
  • NCX/Ncx

Tissue specificity:

Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.

Gene Pathways:

  • Metabolism of proteins
  • Extracellular matrix organization

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Metalloendopeptidase Activity
  • Metallopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Glycoprotein Catabolic Process
  • Multicellular Organism Development
  • Protein Transport
  • Proteolysis
  • Vesicle-Mediated Transport
  • Positive Regulation Of Melanocyte Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ADAM metallopeptidase with thrombospondin type 1 motif, 20| ADAM metallopeptidase with thrombospondin type 1 motif, 9| A306_10457| ADAMTS20| A disintegrin and metalloproteinase with thrombospondin motif 9| A disintegrin and metalloproteinase with thrombospondin motifs 9| a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9| a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9| AS27_11630| AS28_02739| CB1_000353001| Ci-ZF(C2H2)-120| D623_10022731| H920_16030| I79_000337| M91_15549| N300_04494| N301_08169| N302_15801| N303_08586| N305_08539| N306_07178| N307_01052| N308_01279| N309_01307| N310_05323| N320_01537| N321_06929| N322_02616| N324_12428| N325_04820| N328_07451| N330_09764| N332_01716| N333_12595| N334_08463| N336_05854| N339_03660| N341_02153| PAL_GLEAN10022144| PANDA_012197| TREES_T100013386| UY3_12810| Y1Q_003922| Y956_14395| adamts9

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