The Function of ADAM17
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Protein names
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 17Short name:
ADAM 17Alternative name(s):
Snake venom-like proteaseTNF-alpha convertase
TNF-alpha-converting enzyme
CD antigen CD156b
- RS17362650 (ADAM17) ??
- RS55794209 (ADAM17) ??
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Top Gene-Substance Interactions
ADAM17 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADAM17
| Substances | Interaction | Organism | Category |
Substances That Decrease ADAM17
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Gene Pathways:
Induction:
In arthritis-affected cartilage.
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Integrin Binding
- Interleukin-6 Receptor Binding
- Metal Ion Binding
- Metalloendopeptidase Activity
- Metallopeptidase Activity
- Notch Binding
- Pdz Domain Binding
- Zinc Ion Binding
Biological Processes:
- B Cell Differentiation
- Cell Adhesion
- Cell Adhesion Mediated By Integrin
- Cell Motility
- Defense Response To Gram-Positive Bacterium
- Epidermal Growth Factor-Activated Receptor Transactivation By G-Protein Coupled Receptor Signaling Pathway
- Epidermal Growth Factor Receptor Signaling Pathway
- Germinal Center Formation
- Membrane Protein Ectodomain Proteolysis
- Membrane Protein Intracellular Domain Proteolysis
- Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Neutrophil Mediated Immunity
- Notch Receptor Processing
- Notch Signaling Pathway
- Pma-Inducible Membrane Protein Ectodomain Proteolysis
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cellular Component Movement
- Positive Regulation Of Chemokine Production
- Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
- Positive Regulation Of Epidermal Growth Factor-Activated Receptor Activity
- Positive Regulation Of Leukocyte Chemotaxis
- Positive Regulation Of Protein Phosphorylation
- Positive Regulation Of T Cell Chemotaxis
- Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Proteolysis
- Regulation Of Mast Cell Apoptotic Process
- Response To High Density Lipoprotein Particle
- Response To Hypoxia
- Response To Lipopolysaccharide
- Spleen Development
- T Cell Differentiation In Thymus
- Tumor Necrosis Factor-Mediated Signaling Pathway
- Wound Healing, Spreading Of Epidermal Cells