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  3. ADAM17

ADAM17 (ADAM metallopeptidase domain 17)

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The Function of ADAM17

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

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Protein names

Recommended name:

Disintegrin and metalloproteinase domain-containing protein 17

Short name:

ADAM 17

Alternative name(s):

Snake venom-like protease
TNF-alpha convertase
TNF-alpha-converting enzyme
CD antigen CD156b

ADAM17 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17362650 (ADAM17) ??
  2. RS55794209 (ADAM17) ??

Top Gene-Substance Interactions

ADAM17 Interacts with These Diseases

Disease Score

Substances That Increase ADAM17

Substances Interaction Organism Category

Substances That Decrease ADAM17

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • HOXA3
  • IRF-1

Tissue specificity:

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction
  • Apoptosis
  • Alzheimer's disease
  • Epithelial cell signaling in Helicobacter pylori infection
  • Extracellular matrix organization
  • Notch signaling pathway
  • Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Induction:

In arthritis-affected cartilage.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Integrin Binding
  • Interleukin-6 Receptor Binding
  • Metal Ion Binding
  • Metalloendopeptidase Activity
  • Metallopeptidase Activity
  • Notch Binding
  • Pdz Domain Binding
  • Zinc Ion Binding

Biological Processes:

  • B Cell Differentiation
  • Cell Adhesion
  • Cell Adhesion Mediated By Integrin
  • Cell Motility
  • Defense Response To Gram-Positive Bacterium
  • Epidermal Growth Factor-Activated Receptor Transactivation By G-Protein Coupled Receptor Signaling Pathway
  • Epidermal Growth Factor Receptor Signaling Pathway
  • Germinal Center Formation
  • Membrane Protein Ectodomain Proteolysis
  • Membrane Protein Intracellular Domain Proteolysis
  • Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Neutrophil Mediated Immunity
  • Notch Receptor Processing
  • Notch Signaling Pathway
  • Pma-Inducible Membrane Protein Ectodomain Proteolysis
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cellular Component Movement
  • Positive Regulation Of Chemokine Production
  • Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
  • Positive Regulation Of Epidermal Growth Factor-Activated Receptor Activity
  • Positive Regulation Of Leukocyte Chemotaxis
  • Positive Regulation Of Protein Phosphorylation
  • Positive Regulation Of T Cell Chemotaxis
  • Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Proteolysis
  • Regulation Of Mast Cell Apoptotic Process
  • Response To High Density Lipoprotein Particle
  • Response To Hypoxia
  • Response To Lipopolysaccharide
  • Spleen Development
  • T Cell Differentiation In Thymus
  • Tumor Necrosis Factor-Mediated Signaling Pathway
  • Wound Healing, Spreading Of Epidermal Cells
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 14-3-3 protein theta| ADAM 17| ADAM 17 precursor-like protein| ADAM18| ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)| ADAM metallopeptidase domain 18| a disintegrin and metallopeptidase domain 17| a disintegrin and metalloprotease domain 17| a disintegrin and metalloproteinase domain 17| a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)| AS27_15679| AS28_03594| CB1_001616071| CD156b| csvp| D623_10020846| Disintegrin and metalloproteinase domain-containing protein 17| disintegrin and metalloproteinase domain-containing protein 17 preproprotein| GW7_14103| H920_07404| I79_023268| M959_14790| metalloproteinase ADAM17| N300_15343| N301_06687| N302_01868| N303_10496| N305_01622| N306_06091| N308_15455| N309_15037| N312_13594| N320_07078| N321_01084| N324_05176| N325_01740| N327_09427| N328_01582| N330_04122| N331_09920| N332_03079| N334_05173| N335_02068| N339_07142| N340_05111| NISBD| NISBD1| PANDA_012401| snake venom-like protease| Tace| TNF-alpha convertase| TNF-alpha converting enzyme| TNF-alpha-converting enzyme| TREES_T100010477| tumor necrosis factor alpha converting enzyme| tumor necrosis factor-alpha-converting enzyme| tumor necrosis factor, alpha, converting enzyme| UY3_00726| Y1Q_013705| Y956_15341| Z169_02346| adam17

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