The Function of ADAM17
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Protein names
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 17Short name:
ADAM 17Alternative name(s):
Snake venom-like proteaseTNF-alpha convertase
TNF-alpha-converting enzyme
CD antigen CD156b
- RS17362650 (ADAM17) ??
- RS55794209 (ADAM17) ??
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Top Gene-Substance Interactions
ADAM17 Interacts with These Diseases
| Disease | Score |
Substances That Increase ADAM17
| Substances | Interaction | Organism | Category |
Substances That Decrease ADAM17
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Gene Pathways:
Induction:
In arthritis-affected cartilage.
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Metalloendopeptidase Activity
- Notch Binding
- Interleukin-6 Receptor Binding
- Integrin Binding
- Metallopeptidase Activity
- Zinc Ion Binding
- Pdz Domain Binding
- Metal Ion Binding
Biological Processes:
- Response To Hypoxia
- Positive Regulation Of Protein Phosphorylation
- Neutrophil Mediated Immunity
- Germinal Center Formation
- Positive Regulation Of Leukocyte Chemotaxis
- Proteolysis
- Membrane Protein Ectodomain Proteolysis
- Cell Adhesion
- Epidermal Growth Factor Receptor Signaling Pathway
- Notch Signaling Pathway
- Notch Receptor Processing
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of T Cell Chemotaxis
- B Cell Differentiation
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Migration
- Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Membrane Protein Intracellular Domain Proteolysis
- Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
- Response To Lipopolysaccharide
- Positive Regulation Of Chemokine Production
- Regulation Of Mast Cell Apoptotic Process
- T Cell Differentiation In Thymus
- Tumor Necrosis Factor-Mediated Signaling Pathway
- Cell Adhesion Mediated By Integrin
- Wound Healing, Spreading Of Epidermal Cells
- Epidermal Growth Factor-Activated Receptor Transactivation By G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Epidermal Growth Factor-Activated Receptor Activity
- Spleen Development
- Cell Motility
- Defense Response To Gram-Positive Bacterium
- Pma-Inducible Membrane Protein Ectodomain Proteolysis
- Positive Regulation Of Cellular Component Movement
- Response To High Density Lipoprotein Particle