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  3. ADAM10

ADAM10 (ADAM metallopeptidase domain 10)

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The Function of ADAM10

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

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Protein names

Recommended name:

Disintegrin and metalloproteinase domain-containing protein 10

Alternative name(s):

ADAM 10
CDw156
Kuzbanian protein homolog
Mammalian disintegrin-metalloprotease
CD antigen CD156c

ADAM10 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS383902 (ADAM10) ??

Top Gene-Substance Interactions

Substances That Increase ADAM10

Substances Interaction Organism Category

Substances That Decrease ADAM10

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • c-Fos

Tissue specificity:

Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.

Gene Pathways:

  • Disease
  • Signal Transduction
  • Alzheimer's disease
  • Epithelial cell signaling in Helicobacter pylori infection
  • Extracellular matrix organization
  • Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Induction:

In osteoarthritis affected-cartilage.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Endopeptidase Activity
  • Integrin Binding
  • Metal Ion Binding
  • Metalloendopeptidase Activity
  • Metallopeptidase Activity
  • Protein Homodimerization Activity
  • Protein Kinase Binding
  • Receptor Binding
  • Zinc Ion Binding

Biological Processes:

  • Cell-Cell Signaling
  • Constitutive Protein Ectodomain Proteolysis
  • Ephrin Receptor Signaling Pathway
  • Extracellular Matrix Disassembly
  • Integrin-Mediated Signaling Pathway
  • In Utero Embryonic Development
  • Membrane Protein Ectodomain Proteolysis
  • Monocyte Activation
  • Negative Regulation Of Cell Adhesion
  • Notch Receptor Processing
  • Notch Signaling Pathway
  • Pma-Inducible Membrane Protein Ectodomain Proteolysis
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of T Cell Chemotaxis
  • Protein Phosphorylation
  • Protein Processing
  • Response To Tumor Necrosis Factor
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AD10| AD18| ADAM 10| ADAM-10| ADAM10 metallopeptidase| a disintegrin and metallopeptidase domain 10| a disintegrin and metalloprotease domain 10| a disintegrin and metalloprotease domain (ADAM) 10| a disintegrin and metalloproteinase domain 10| AS27_14911| AS28_04210| CD156c| CDw156| D623_10007056| Disintegrin and metalloproteinase domain-containing protein 10| disintegrin metalloproteinase| disintegrin-metalloproteinase| H920_12604| HsT18717| I79_000174| kuz| kuzbanian| kuzbanian protein homolog| M91_14882| M959_05263| madm| mammalian disintegrin-metalloprotease| MDA_GLEAN10012027| myelin-associated metalloproteinase| N300_11933| N301_08226| N302_04904| N303_08267| N305_08052| N306_09275| N307_06519| N308_02776| N309_04871| N310_09129| N311_12861| N312_09131| N320_10900| N322_11802| N324_04991| N326_04726| N327_08543| N328_05139| N329_10761| N330_02319| N331_11544| N332_13138| N333_07556| N335_13084| N336_10521| N339_07787| N340_10673| N341_05850| PAL_GLEAN10023430| PANDA_019470| RAK| RGD1566370| TREES_T100000225| UY3_03823| xadam10| Y1Q_013892| Y956_05560| Z169_06651| adam10

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