The Function of ADAM10
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
Protein names
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 10Alternative name(s):
ADAM 10CDw156
Kuzbanian protein homolog
Mammalian disintegrin-metalloprotease
CD antigen CD156c
- RS383902 (ADAM10) ??
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Top Gene-Substance Interactions
Substances That Increase ADAM10
| Substances | Interaction | Organism | Category |
Substances That Decrease ADAM10
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
Gene Pathways:
Induction:
In osteoarthritis affected-cartilage.
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Endopeptidase Activity
- Integrin Binding
- Metal Ion Binding
- Metalloendopeptidase Activity
- Metallopeptidase Activity
- Protein Homodimerization Activity
- Protein Kinase Binding
- Receptor Binding
- Zinc Ion Binding
Biological Processes:
- Cell-Cell Signaling
- Constitutive Protein Ectodomain Proteolysis
- Ephrin Receptor Signaling Pathway
- Extracellular Matrix Disassembly
- Integrin-Mediated Signaling Pathway
- In Utero Embryonic Development
- Membrane Protein Ectodomain Proteolysis
- Monocyte Activation
- Negative Regulation Of Cell Adhesion
- Notch Receptor Processing
- Notch Signaling Pathway
- Pma-Inducible Membrane Protein Ectodomain Proteolysis
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of T Cell Chemotaxis
- Protein Phosphorylation
- Protein Processing
- Response To Tumor Necrosis Factor