The Function of ACVR2B
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
Protein names
Recommended name:
Activin receptor type-2BShort name:
ACTR-IIBAlternative name(s):
Activin receptor type IIBTop Gene-Substance Interactions
Substances That Increase ACVR2B
| Substances | Interaction | Organism | Category |
Substances That Decrease ACVR2B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Serine/Threonine Kinase Activity
- Transmembrane Receptor Protein Serine/Threonine Kinase Activity
- Signal Transducer, Downstream Of Receptor, With Serine/Threonine Kinase Activity
- Protein Serine/Threonine/Tyrosine Kinase Activity
- Atp Binding
- Growth Factor Binding
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Gastrulation With Mouth Forming Second
- Kidney Development
- Lymphangiogenesis
- Blood Vessel Remodeling
- Regulation Of Transcription, Dna-Templated
- Signal Transduction
- Transmembrane Receptor Protein Serine/Threonine Kinase Signaling Pathway
- Determination Of Left/Right Symmetry
- Mesoderm Development
- Heart Development
- Response To Glucose
- Post-Embryonic Development
- Anterior/Posterior Pattern Specification
- Insulin Secretion
- Lung Development
- Positive Regulation Of Bone Mineralization
- Bmp Signaling Pathway
- Pancreas Development
- Activation Of Protein Kinase Activity
- Activin Receptor Signaling Pathway
- Positive Regulation Of Activin Receptor Signaling Pathway
- Organ Growth
- Odontogenesis Of Dentin-Containing Tooth
- Positive Regulation Of Osteoblast Differentiation
- Embryonic Foregut Morphogenesis
- Skeletal System Morphogenesis
- Palate Development
- Lymphatic Endothelial Cell Differentiation
- Artery Development
- Venous Blood Vessel Development
- Retina Vasculature Development In Camera-Type Eye