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  3. ACTN1

ACTN1 (Actinin alpha 1)

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The Function of ACTN1

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

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Protein names

Recommended name:

Alpha-actinin-1

Alternative name(s):

Alpha-actinin cytoskeletal isoform
F-actin cross-linking protein
Non-muscle alpha-actinin-1

ACTN1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12050161 (ACTN1) ??
  2. RS2268983 (ACTN1) ??
  3. RS229353 (ACTN1) ??
  4. RS434943 (ACTN1) ??
  5. RS76745467 (ACTN1) ??
  6. RS8003722 (ACTN1) ??

Top Gene-Substance Interactions

Substances That Increase ACTN1

Substances Interaction Organism Category

Substances That Decrease ACTN1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • AhR
  • Arnt
  • YY1
  • Pax-5
  • MIF-1
  • p300
  • Ik-1

Gene Pathways:

  • Regulation of actin cytoskeleton
  • Hemostasis
  • Adherens junction
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Cell-Cell communication
  • Leukocyte transendothelial migration
  • Tight junction
  • Extracellular matrix organization
  • Amoebiasis
  • Systemic lupus erythematosus

Molecular Function:

  • Actin Filament Binding
  • Calcium Ion Binding
  • Double-Stranded Rna Binding
  • Integrin Binding
  • Ion Channel Binding
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Protein Homodimerization Activity
  • Vinculin Binding

Biological Processes:

  • Actin Crosslink Formation
  • Actin Filament Bundle Assembly
  • Actin Filament Network Formation
  • Actin Filament Organization
  • Focal Adhesion Assembly
  • Negative Regulation Of Cellular Component Movement
  • Platelet Degranulation
  • Platelet Formation
  • Platelet Morphogenesis
  • Regulation Of Apoptotic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08013| a-actinin| actinin| actinin 1 smooth muscle| actinin, alpha 1| actinin, alpha 1 isoform 6-like protein| Actn1a| alpha actinin| alpha-actinin 1| alpha-actinin-1| alpha actinin 1a| alpha-actinin 1-like protein| alpha-actinin cytoskeletal isoform| AS27_08463| AS28_08436| BDPLT15| CB1_000898017| F-actin cross-linking protein| H920_14333| I79_004057| M91_10586| M959_13252| MDA_GLEAN10017584| N300_01965| N301_08607| N302_01671| N303_07130| N306_10763| N308_09197| N309_08045| Non-muscle alpha-actinin-1| PAL_GLEAN10009933| PANDA_005239| TREES_T100011048| Y1Q_027950| Y956_16559| Z169_03981| actn1

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