The Function of ACTN1
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
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Protein names
Recommended name:
Alpha-actinin-1Alternative name(s):
Alpha-actinin cytoskeletal isoformF-actin cross-linking protein
Non-muscle alpha-actinin-1
- RS12050161 (ACTN1) ??
- RS2268983 (ACTN1) ??
- RS229353 (ACTN1) ??
- RS434943 (ACTN1) ??
- RS76745467 (ACTN1) ??
- RS8003722 (ACTN1) ??
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Top Gene-Substance Interactions
Substances That Increase ACTN1
| Substances | Interaction | Organism | Category |
Substances That Decrease ACTN1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Actin Filament Binding
- Calcium Ion Binding
- Double-Stranded Rna Binding
- Integrin Binding
- Ion Channel Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Protein Homodimerization Activity
- Vinculin Binding
Biological Processes:
- Actin Crosslink Formation
- Actin Filament Bundle Assembly
- Actin Filament Network Formation
- Actin Filament Organization
- Focal Adhesion Assembly
- Negative Regulation Of Cellular Component Movement
- Platelet Degranulation
- Platelet Formation
- Platelet Morphogenesis
- Regulation Of Apoptotic Process