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  3. ACTA2

ACTA2 (Actin, alpha 2, smooth muscle, aorta)

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The Function of ACTA2

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

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Protein names

Recommended name:

Actin, aortic smooth muscle

Alternative name(s):

Alpha-actin-2
Cell growth-inhibiting gene 46 protein

ACTA2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1800682 (ACTA2) ??
  2. RS1926203 (ACTA2) ??
  3. RS2234767 (ACTA2) ??

Top Gene-Substance Interactions

ACTA2 Interacts with These Diseases

Disease Score

Substances That Increase ACTA2

Substances Interaction Organism Category

Substances That Decrease ACTA2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Egr-1
  • AP-1
  • c-Jun
  • C/EBPbeta
  • Sp1

Gene Pathways:

  • Vascular smooth muscle contraction
  • Muscle contraction

Induction:

Up-regulated in response to enterovirus 71 (EV71) infection.

Molecular Function:

  • Atp Binding
  • Protein Kinase Binding

Biological Processes:

  • Glomerular Mesangial Cell Development
  • Mesenchyme Migration
  • Muscle Contraction
  • Positive Regulation Of Gene Expression
  • Regulation Of Blood Pressure
  • Response To Virus
  • Vascular Smooth Muscle Contraction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| acta2| alpha-actin| ASMA| AAT6| ACT-4| actc1| actin| actin alpha 2| actin alpha cardiac 1| Actin, alpha skeletal muscle B| actin, alpha, vascular smooth muscle| actin, aortic smooth muscle| actsa| Actvs| alpha 2 actin| alpha actin| alpha actin 2| alpha-actin-2| alpha-cardiac actin| alphaSMA| alpha-SM-actin| alpha smooth muscle actin| alpha-smooth muscle actin| AS27_02601| AS28_04464| a-sma| cell growth-inhibiting gene 46 protein| EH28_02765| GW7_19357| H920_15326| I79_013242| M959_09881| MDA_GLEAN10001175| MYMY5| N300_07507| N301_10649| N302_13485| N303_09192| N306_13860| N308_09044| N309_12738| N310_12123| N311_10607| N312_10769| N327_07894| N331_04653| N332_14756| N333_12208| N336_02273| N339_03540| PANDA_002328| sma| sm-actin| SMactin| SM actin| SMalphaA| smooth muscle alpha actin| smooth muscle alpha-actin| TREES_T100006471| UY3_18313| vascular smooth muscle alpha-actin| Y1Q_023576| Y956_01522| Z169_12810

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