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  3. ACSS1

ACSS1 (Acyl-CoA synthetase short-chain family member 1)

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The Function of ACSS1

Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).

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Protein names

Recommended name:

Acetyl-coenzyme A synthetase 2-like, mitochondrial

Alternative name(s):

Acetate--CoA ligase 2
Acetyl-CoA synthetase 2
AceCS2
Acyl-CoA synthetase short-chain family member 1

ACSS1 SNPs

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  1. RS6050267 (ACSS1) ??

Top Gene-Substance Interactions

Substances That Increase ACSS1

Substances Interaction Organism Category

Substances That Decrease ACSS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Jun
  • MEF-2A
  • NF-E2
  • NF-E2 p45
  • AREB6
  • Fra-1
  • ATF6

Enzyme Regulation:

Inhibited by acetylation at Lys-642 and activated by deacetylation.

Molecular Function:

  • Acetate-Coa Ligase Activity
  • Amp Binding
  • Atp Binding

Biological Processes:

  • Acetate Biosynthetic Process
  • Acetyl-Coa Biosynthetic Process
  • Acetyl-Coa Biosynthetic Process From Acetate
  • Ethanol Oxidation
  • Propionate Biosynthetic Process

Drug Bank:

  • Adenosine Triphosphate
  • Adenosine Monophosphate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08189| ACAS2| ACAS2L| ACECS1| AceCS2| acecs2l| acetate--CoA ligase 2| acetyl-CoA synthetase 2| acetyl-coenzyme A synthetase 2-like, mitochondrial| acetyl-coenzyme A synthetase 2-like, mitochondrial-like protein| ACS2L| ACSS1A| ACSS2| acyl-CoA synthetase short-chain family member 2| AS27_06119| AS28_06166| CB1_000120010| GW7_03736| I79_006121| M91_20800| M959_14127| MDA_GLEAN10004506| N300_05406| N301_10131| N302_15179| N303_12253| N305_14174| N306_12855| N308_05815| N309_11469| N310_09015| N311_02207| N312_13062| N320_00055| N321_08791| N322_06647| N324_01097| N325_06939| N326_02607| N327_07923| N328_04719| N330_05792| N332_00824| N333_02073| N334_12589| N335_02029| N336_07457| N339_12517| N340_14800| PAL_GLEAN10002752| PANDA_019519| TREES_T100008148| Y1Q_029695| Y956_12671| Z169_03203| acss1

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