The Function of ACSS1
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
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Protein names
Recommended name:
Acetyl-coenzyme A synthetase 2-like, mitochondrialAlternative name(s):
Acetate--CoA ligase 2Acetyl-CoA synthetase 2
AceCS2
Acyl-CoA synthetase short-chain family member 1
- RS6050267 (ACSS1) ??
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Top Gene-Substance Interactions
Substances That Increase ACSS1
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Substances That Decrease ACSS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Inhibited by acetylation at Lys-642 and activated by deacetylation.
Molecular Function:
Biological Processes:
- Acetate Biosynthetic Process
- Acetyl-Coa Biosynthetic Process
- Acetyl-Coa Biosynthetic Process From Acetate
- Ethanol Oxidation
- Propionate Biosynthetic Process
Drug Bank:
- Adenosine Triphosphate
- Adenosine Monophosphate