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  3. ACSM3

ACSM3 (Acyl-CoA synthetase medium-chain family member 3)

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The Function of ACSM3

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

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Protein names

Recommended name:

Acyl-coenzyme A synthetase ACSM3, mitochondrial

Alternative name(s):

Acyl-CoA synthetase medium-chain family member 3
Butyrate--CoA ligase 3
Butyryl-coenzyme A synthetase 3
Middle-chain acyl-CoA synthetase 3
Protein SA homolog

Top Gene-Substance Interactions

ACSM3 Interacts with These Diseases

Disease Score

Substances That Increase ACSM3

Substances Interaction Organism Category

Substances That Decrease ACSM3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • AhR
  • STAT3
  • PPAR-alpha
  • STAT5A
  • STAT1
  • STAT1alpha

Gene Pathways:

  • Metabolic pathways
  • Butanoate metabolism

Caution:

It is uncertain whether Met-1 or Met-9 is the initiator.

Molecular Function:

  • Acyl-Coa Ligase Activity
  • Atp Binding
  • Butyrate-Coa Ligase Activity
  • Fatty Acid Ligase Activity
  • Fatty-Acyl-Coa Synthase Activity
  • Metal Ion Binding

Biological Processes:

  • Acyl-Coa Metabolic Process
  • Cholesterol Homeostasis
  • Fatty Acid Biosynthetic Process
  • Regulation Of Blood Pressure
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04775| acyl-coenzyme A synthetase ACSM3| Acyl-coenzyme A synthetase ACSM3, mitochondrial| butyrate--CoA ligase 3| butyryl-coenzyme A synthetase 3| CH73-60L17.3| D623_10015889| EGK_12571| M91_09111| MDA_GLEAN10006931| middle-chain acyl-CoA synthetase 3| N312_07674| N324_12296| N336_04029| N339_01119| PAL_GLEAN10004999| PANDA_017445| protein SA| protein SA homolog| SA| SAH| SA hypertension-associated homolog| SA (rat hypertension-associated) homolog| SA rat hypertension-associated homolog| SA rat hypertension-associated protein| ssubA| UY3_11335| acsm3

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