The Function of ACSM3
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).
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Protein names
Recommended name:
Acyl-coenzyme A synthetase ACSM3, mitochondrialAlternative name(s):
Acyl-CoA synthetase medium-chain family member 3Butyrate--CoA ligase 3
Butyryl-coenzyme A synthetase 3
Middle-chain acyl-CoA synthetase 3
Protein SA homolog
Top Gene-Substance Interactions
ACSM3 Interacts with These Diseases
| Disease | Score |
Substances That Increase ACSM3
| Substances | Interaction | Organism | Category |
Substances That Decrease ACSM3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
It is uncertain whether Met-1 or Met-9 is the initiator.
Molecular Function:
- Acyl-Coa Ligase Activity
- Atp Binding
- Fatty Acid Ligase Activity
- Metal Ion Binding
- Butyrate-Coa Ligase Activity
- Fatty-Acyl-Coa Synthase Activity
Biological Processes:
- Fatty Acid Biosynthetic Process
- Acyl-Coa Metabolic Process
- Regulation Of Blood Pressure
- Cholesterol Homeostasis