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  3. ACSL6

ACSL6 (Acyl-CoA synthetase long-chain family member 6)

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The Function of ACSL6

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.

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Protein names

Recommended name:

Long-chain-fatty-acid--CoA ligase 6

Short name:

LACS 6

Alternative name(s):

Long-chain acyl-CoA synthetase 6

ACSL6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS476428 (ACSL6) ??

Top Gene-Substance Interactions

ACSL6 Interacts with These Diseases

Disease Score

Substances That Increase ACSL6

Substances Interaction Organism Category

Substances That Decrease ACSL6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Peroxisome
  • Fatty acid metabolism
  • PPAR signaling pathway
  • Adipocytokine signaling pathway

Developmental stage:

Expression is low at earlier stages of erythroid development but is very high in reticulocytes.

Molecular Function:

  • Atp Binding
  • Decanoate--Coa Ligase Activity
  • Enzyme Binding
  • Long-Chain Fatty Acid-Coa Ligase Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Acyl-Coa Metabolic Process
  • Long-Chain Fatty Acid Metabolic Process
  • Long-Chain Fatty-Acyl-Coa Biosynthetic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| acsl6| LACS| LACS2| A306_14608| ACS2| Anapl_09854| AS27_12088| AS28_08209| CB1_000719021| D623_10032546| FACL6| fatty acid Coenzyme A ligase, long chain 6| fatty-acid-Coenzyme A ligase, long-chain 6| H920_12018| LACS5| LACS 6| Lacsl| long-chain acyl-CoA synthetase 6| Long-chain-fatty-acid--CoA ligase 6| long-chain-fatty-acid-CoA ligase 6-like protein| long-chain-fatty-acid--CoA ligase, brain isozyme| long fatty acyl-CoA synthetase 2| M91_18690| M959_03900| N300_11023| N301_09254| N302_09913| N303_10901| N305_08717| N306_02112| N307_02788| N308_05297| N309_08394| N310_03384| N312_12271| N320_02521| N322_11144| N325_02611| N326_03392| N327_12884| N329_10292| N330_09594| N331_06979| N332_06352| N333_08125| N339_11705| N340_07991| N341_06790| PAL_GLEAN10016906| PANDA_000718| TREES_T100018931| UY3_01114| Y1Q_028975| Y956_06247| Z169_00084

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