The Function of ACSL6
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
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Protein names
Recommended name:
Long-chain-fatty-acid--CoA ligase 6Short name:
LACS 6Alternative name(s):
Long-chain acyl-CoA synthetase 6- RS476428 (ACSL6) ??
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Top Gene-Substance Interactions
ACSL6 Interacts with These Diseases
| Disease | Score |
Substances That Increase ACSL6
| Substances | Interaction | Organism | Category |
Substances That Decrease ACSL6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
Gene Pathways:
Developmental stage:
Expression is low at earlier stages of erythroid development but is very high in reticulocytes.
Molecular Function:
- Atp Binding
- Decanoate--Coa Ligase Activity
- Enzyme Binding
- Long-Chain Fatty Acid-Coa Ligase Activity
- Protein Homodimerization Activity
Biological Processes:
- Acyl-Coa Metabolic Process
- Long-Chain Fatty Acid Metabolic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process