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  3. ACP5

ACP5 (Acid phosphatase 5, tartrate resistant)

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The Function of ACP5

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

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Protein names

Recommended name:

Tartrate-resistant acid phosphatase type 5

Short name:

TR-AP

Alternative name(s):

Tartrate-resistant acid ATPase
TrATPase
Type 5 acid phosphatase

ACP5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7253363 (ACP5) ??

Top Gene-Substance Interactions

ACP5 Interacts with These Diseases

Disease Score

Substances That Increase ACP5

Substances Interaction Organism Category

Substances That Decrease ACP5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Ik-1
  • GCNF

Gene Pathways:

  • Metabolism
  • Disease
  • Osteoclast differentiation
  • Lysosome
  • Rheumatoid arthritis
  • Riboflavin metabolism

Cofactor:

Binds 2 iron ions per subunit.

Molecular Function:

  • Acid Phosphatase Activity
  • Ferric Iron Binding
  • Ferrous Iron Binding

Biological Processes:

  • Bone Morphogenesis
  • Bone Resorption
  • Defense Response To Gram-Positive Bacterium
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of Interleukin-12 Production
  • Negative Regulation Of Interleukin-1 Beta Production
  • Negative Regulation Of Nitric Oxide Biosynthetic Process
  • Negative Regulation Of Superoxide Anion Generation
  • Negative Regulation Of Tumor Necrosis Factor Production
  • Response To Cytokine
  • Response To Lipopolysaccharide
  • Riboflavin Metabolic Process
  • Multicellular Organismal Response To Stress
  • Negative Regulation Of Cell Adhesion
  • Ossification
  • Osteoclast Differentiation
  • Positive Regulation Of Cell Migration
  • Response To Cholesterol
  • Response To L-Ascorbic Acid
  • Response To Zinc Ion

Drug Bank:

  • Isopropyl Alcohol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| acid phosphatase type 5| acid phosphatase type V| EH28_02896| GW7_01722| HPAP| human purple acid phosphatase| M91_04891| MDA_GLEAN10009359| PAL_GLEAN10002382| PANDA_021498| ppa5| tartrate-resistant acid ATPase| tartrate-resistant acid phosphatase| tartrate-resistant acid phosphatase 5a| tartrate-resistant acid phosphatase 5b| Tartrate-resistant acid phosphatase type 5| tartrate-resistant acid phosphatase type 5-like| TRACP| TRACP5a| TRACP5b| TRAP| TR-AP| trATPase| TREES_T100001191| TTRRAP| type 5 acid phosphatase| UF| uteroferrin| UY3_05564| Y1Q_001582| acp5

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