The Function of ACP5
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
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Protein names
Recommended name:
Tartrate-resistant acid phosphatase type 5Short name:
TR-APAlternative name(s):
Tartrate-resistant acid ATPaseTrATPase
Type 5 acid phosphatase
- RS7253363 (ACP5) ??
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Top Gene-Substance Interactions
ACP5 Interacts with These Diseases
| Disease | Score |
Substances That Increase ACP5
| Substances | Interaction | Organism | Category |
Substances That Decrease ACP5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 2 iron ions per subunit.
Molecular Function:
Biological Processes:
- Bone Morphogenesis
- Bone Resorption
- Defense Response To Gram-Positive Bacterium
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Interleukin-12 Production
- Negative Regulation Of Interleukin-1 Beta Production
- Negative Regulation Of Nitric Oxide Biosynthetic Process
- Negative Regulation Of Superoxide Anion Generation
- Negative Regulation Of Tumor Necrosis Factor Production
- Response To Cytokine
- Response To Lipopolysaccharide
- Riboflavin Metabolic Process
- Multicellular Organismal Response To Stress
- Negative Regulation Of Cell Adhesion
- Ossification
- Osteoclast Differentiation
- Positive Regulation Of Cell Migration
- Response To Cholesterol
- Response To L-Ascorbic Acid
- Response To Zinc Ion
Drug Bank:
- Isopropyl Alcohol