The Function of ACOT4
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.
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Protein names
Recommended name:
Acyl-coenzyme A thioesterase 4Alternative name(s):
Acyl-CoA thioesterase 4PTE-2b
Peroxisomal acyl coenzyme A thioester hydrolase Ib
Peroxisomal long-chain acyl-CoA thioesterase Ib
PTE-Ib
- RS55951657 (ACOT4) ??
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Top Gene-Substance Interactions
Substances That Increase ACOT4
| Substances | Interaction | Organism | Category |
Substances That Decrease ACOT4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.
Molecular Function:
- Acyl-Coa Hydrolase Activity
- Carboxylic Ester Hydrolase Activity
- Palmitoyl-Coa Hydrolase Activity
- Receptor Binding
- Succinyl-Coa Hydrolase Activity
Biological Processes:
- Acyl-Coa Metabolic Process
- Dicarboxylic Acid Catabolic Process
- Dicarboxylic Acid Metabolic Process
- Long-Chain Fatty Acid Metabolic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process
- Saturated Monocarboxylic Acid Metabolic Process
- Short-Chain Fatty Acid Metabolic Process
- Succinyl-Coa Metabolic Process
- Unsaturated Monocarboxylic Acid Metabolic Process
- Very Long-Chain Fatty Acid Metabolic Process