The Function of ACOT1
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16.
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Protein names
Recommended name:
Acyl-coenzyme A thioesterase 1Short name:
CTE-IAlternative name(s):
Acyl-CoA thioesterase 1CTE-Ib
Inducible cytosolic acyl-coenzyme A thioester hydrolase
Long chain acyl-CoA thioester hydrolase
Long chain acyl-CoA hydrolase
- RS2041073 (ACOT1) ??
- RS8018967 (ACOT1) ??
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Top Gene-Substance Interactions
ACOT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ACOT1
| Substances | Interaction | Organism | Category |
Substances That Decrease ACOT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Very Long-Chain Fatty Acid Metabolic Process
- Long-Chain Fatty Acid Metabolic Process
- Acyl-Coa Metabolic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process