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  3. ACOT1

ACOT1 (Acyl-CoA thioesterase 1)

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The Function of ACOT1

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16.

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Protein names

Recommended name:

Acyl-coenzyme A thioesterase 1

Short name:

CTE-I

Alternative name(s):

Acyl-CoA thioesterase 1
CTE-Ib
Inducible cytosolic acyl-coenzyme A thioester hydrolase
Long chain acyl-CoA thioester hydrolase
Long chain acyl-CoA hydrolase

ACOT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2041073 (ACOT1) ??
  2. RS8018967 (ACOT1) ??

Top Gene-Substance Interactions

ACOT1 Interacts with These Diseases

Disease Score

Substances That Increase ACOT1

Substances Interaction Organism Category

Substances That Decrease ACOT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2

Gene Pathways:

  • Biosynthesis of unsaturated fatty acids

Molecular Function:

  • Acyl-Coa Hydrolase Activity
  • Carboxylic Ester Hydrolase Activity
  • Palmitoyl-Coa Hydrolase Activity

Biological Processes:

  • Acyl-Coa Metabolic Process
  • Long-Chain Fatty Acid Metabolic Process
  • Long-Chain Fatty-Acyl-Coa Biosynthetic Process
  • Very Long-Chain Fatty Acid Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

ACH2| acyl-CoA thioesterase 1, cytosolic| acyl-coenzyme A thioesterase 1| Cte1| CTE-1| CTE-I| CTE-Ib| cytosolic acyl-CoA thioesterase 1| D12Ucla1| inducible cytosolic acyl-coenzyme A thioester hydrolase| LACH2| long chain acyl-CoA hydrolase| long chain acyl-CoA thioester hydrolase| UY3_03170| acot1

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