The Function of ACO2
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
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Protein names
Recommended name:
Aconitate hydratase, mitochondrialAlternative name(s):
AconitaseCitrate hydro-lyase
- RS727563 (ACO2) ??
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Top Gene-Substance Interactions
Substances That Increase ACO2
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Substances That Decrease ACO2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme.
Molecular Function:
- Aconitate Hydratase Activity
- Iron Ion Binding
- 3 Iron, 4 Sulfur Cluster Binding
- 4 Iron, 4 Sulfur Cluster Binding
Biological Processes:
- Generation Of Precursor Metabolites And Energy
- Tricarboxylic Acid Cycle
- Citrate Metabolic Process
- Isocitrate Metabolic Process