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  3. ACO2

ACO2 (Aconitase 2)

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The Function of ACO2

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

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Protein names

Recommended name:

Aconitate hydratase, mitochondrial

Alternative name(s):

Aconitase
Citrate hydro-lyase

ACO2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS727563 (ACO2) ??

Top Gene-Substance Interactions

Substances That Increase ACO2

Substances Interaction Organism Category

Substances That Decrease ACO2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • Nkx2-5
  • E2F-1
  • E2F-4
  • E2F-5

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Citrate cycle (TCA cycle)
  • Metabolism of proteins
  • Metabolism
  • Glyoxylate and dicarboxylate metabolism

Cofactor:

Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme.

Molecular Function:

  • 3 Iron, 4 Sulfur Cluster Binding
  • 4 Iron, 4 Sulfur Cluster Binding
  • Aconitate Hydratase Activity
  • Iron Ion Binding

Biological Processes:

  • Citrate Metabolic Process
  • Generation Of Precursor Metabolites And Energy
  • Isocitrate Metabolic Process
  • Tricarboxylic Acid Cycle
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| citrate hydro-lyase| A306_00970| Aco-2| Aco3| aconitase 2, mitochondrial| Aconitate hydratase| Aconitate hydratase, mitochondrial| aconitate hydratase, mitochondrial-like| aconitate hydratase, mitochondrial-like protein| ACONM| AS27_07913| AS28_12519| CB1_000168028| D10Wsu183e| D623_10013963| epididymis secretory sperm binding protein Li 284| heart aconitase| HEL-S-284| ICRD| M91_08488| M959_09532| mitochondrial aconitase| mitochondrial aconitase (nuclear aco2 gene)| mitochondrial aconitate hydratase| N300_13179| N301_05924| N302_12755| N303_02837| N305_13983| N306_07379| N307_05070| N308_03320| N309_02251| N310_09681| N312_01067| N320_02503| N321_04332| N324_11069| N325_00918| N326_00728| N327_08991| N328_08451| N329_09765| N331_08854| N333_02084| N334_11861| N335_09008| N336_11452| N339_09336| N340_10451| N341_08506| OCA8| OPA9| PAL_GLEAN10007228| PANDA_019486| TREES_T100012006| UY3_00899| Y1Q_002999| Y956_01255| Z169_12083| aco2

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