The Function of ACO1
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
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Protein names
Recommended name:
Cytoplasmic aconitate hydrataseShort name:
IRP1Alternative name(s):
AconitaseCitrate hydro-lyase
Ferritin repressor protein
Iron regulatory protein 1
Iron-responsive element-binding protein 1
IRE-BP 1
- RS10970976 (ACO1) ??
- RS4878497 (ACO1) ??
- RS7032871 (ACO1) ??
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Top Gene-Substance Interactions
ACO1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ACO1
| Substances | Interaction | Organism | Category |
Substances That Decrease ACO1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Cofactor:
Binds 1 [4Fe-4S] cluster per subunit.
Molecular Function:
- 4 Iron, 4 Sulfur Cluster Binding
- Aconitate Hydratase Activity
- Iron-Responsive Element Binding
- Metal Ion Binding
- Rna Binding
Biological Processes:
- Cellular Iron Ion Homeostasis
- Citrate Metabolic Process
- Intestinal Absorption
- Post-Embryonic Development
- Regulation Of Translation
- Response To Iron(Ii) Ion
- Tricarboxylic Acid Cycle