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  3. ACO1

ACO1 (Aconitase 1)

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The Function of ACO1

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

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Protein names

Recommended name:

Cytoplasmic aconitate hydratase

Short name:

IRP1

Alternative name(s):

Aconitase
Citrate hydro-lyase
Ferritin repressor protein
Iron regulatory protein 1
Iron-responsive element-binding protein 1
IRE-BP 1

ACO1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10970976 (ACO1) ??
  2. RS4878497 (ACO1) ??
  3. RS7032871 (ACO1) ??

Top Gene-Substance Interactions

ACO1 Interacts with These Diseases

Disease Score

Substances That Increase ACO1

Substances Interaction Organism Category

Substances That Decrease ACO1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • GATA-1
  • GATA-2
  • GATA-3
  • NF-kappaB2
  • RelA

Gene Pathways:

  • Metabolic pathways
  • Citrate cycle (TCA cycle)
  • Glyoxylate and dicarboxylate metabolism

Cofactor:

Binds 1 [4Fe-4S] cluster per subunit.

Molecular Function:

  • 4 Iron, 4 Sulfur Cluster Binding
  • Aconitate Hydratase Activity
  • Iron-Responsive Element Binding
  • Metal Ion Binding
  • Rna Binding

Biological Processes:

  • Cellular Iron Ion Homeostasis
  • Citrate Metabolic Process
  • Intestinal Absorption
  • Post-Embryonic Development
  • Regulation Of Translation
  • Response To Iron(Ii) Ion
  • Tricarboxylic Acid Cycle

Drug Bank:

  • Manganese
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Aco-1| Acon1| aconitase 1, soluble| aconitate hydratase, cytoplasmic| ACONS| AH| Anapl_16357| AS27_03553| AS28_01901| CB1_001797001| citrate hydro-lyase| cytoplasmic aconitase| Cytoplasmic aconitate hydratase| cytosplasmic aconitase| epididymis luminal protein 60| ferritin repressor protein| FRP| GW7_13107| H920_18852| HEL60| I79_013257| ireb1| IRE-binding protein 1| IREBP| IREBP1| IRE-BP 1| iron regulatory protein 1| Iron responsive element binding protein| Iron-responsive element-binding protein 1| iron-responsive element-binding protein 1-like protein| irp1| M91_00565| MDA_GLEAN10003279| N300_12747| N301_13354| N302_05695| N303_08325| N310_13330| N311_06758| N312_01170| N320_09571| N321_05602| N322_10622| N324_11704| N325_09171| N327_05497| N328_11208| N329_04194| N330_05627| N331_01001| N332_06257| N333_08077| N334_10527| N336_02994| N339_10165| N340_14146| N341_06798| PAL_GLEAN10017067| PANDA_018226| soluble aconitase| soluble aconitase 1| UY3_12102| Y1Q_025519| Y956_07994| Z169_06270| aco1

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