Summary of ACHE
The ACHE gene codes for acetylcholinesterase. Acetylcholinesterase is an enzyme that helps break down the nervous system messenger (neurotransmitter) acetylcholine [R].
Acetylcholine plays many important roles, such as [R]:
- Triggering muscle tension
- Dilating blood vessels
- Boosting memory
ACHE variants are linked to stress and anxiety [R].
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
AcetylcholinesteraseAlternative name(s):
AChE- RS13245899 (ACHE) ??
- RS1799805 (ACHE) ??
- RS6976053 (ACHE) ??
- RS7636 (ACHE) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ACHE Interacts with These Diseases
| Disease | Score |
Substances That Increase ACHE
| Substances | Interaction | Organism | Category |
Substances That Decrease ACHE
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform H is highly expressed in erythrocytes.
Molecular Function:
- Beta-Amyloid Binding
- Acetylcholinesterase Activity
- Cholinesterase Activity
- Collagen Binding
- Hydrolase Activity
- Serine Hydrolase Activity
- Acetylcholine Binding
- Protein Homodimerization Activity
- Laminin Binding
Biological Processes:
- Acetylcholine Catabolic Process In Synaptic Cleft
- Regulation Of Receptor Recycling
- Osteoblast Development
- Dna Replication
- Acetylcholine Catabolic Process
- Phosphatidylcholine Biosynthetic Process
- Cell Adhesion
- Nervous System Development
- Synapse Assembly
- Muscle Organ Development
- Cell Proliferation
- Response To Wounding
- Receptor Internalization
- Negative Regulation Of Synaptic Transmission, Cholinergic
- Neurotransmitter Biosynthetic Process
- Amyloid Precursor Protein Metabolic Process
- Neurotransmitter Receptor Biosynthetic Process
- Positive Regulation Of Protein Secretion
- Protein Tetramerization
- Retina Development In Camera-Type Eye
Drug Bank:
- Ambenonium
- Dimetacrine
- Pyridostigmine
- Choline
- Decamethonium
- Demecarium
- Dipivefrin
- Donepezil
- Edrophonium
- Galantamine
- Gallamine Triethiodide
- Isoflurophate
- Mefloquine
- Minaprine
- Neostigmine
- Pralidoxime
- Rivastigmine
- Tubocurarine
- Acetylcholine
- Ephedrine
- Physostigmine