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  3. ACHE

ACHE (Acetylcholinesterase (Cartwright blood group))

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Summary of ACHE

Acetylcholinesterase is an enzyme that breaks down acetylcholine.

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The Function of ACHE

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.

Protein names

Recommended name:

Acetylcholinesterase

Alternative name(s):

AChE

ACHE SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13245899 (ACHE) ??
  2. RS1799805 (ACHE) ??
  3. RS6976053 (ACHE) ??
  4. RS7636 (ACHE) ??

Top Gene-Substance Interactions

ACHE Interacts with These Diseases

Disease Score

Substances That Increase ACHE

Substances Interaction Organism Category

Substances That Decrease ACHE

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • NF-kappaB1
  • Sp1
  • TBP
  • TFIID

Tissue specificity:

Isoform H is highly expressed in erythrocytes.

Gene Pathways:

  • Metabolism
  • Metabolism of proteins
  • Neuronal System
  • Glycerophospholipid metabolism

Molecular Function:

  • Acetylcholine Binding
  • Acetylcholinesterase Activity
  • Beta-Amyloid Binding
  • Cholinesterase Activity
  • Collagen Binding
  • Hydrolase Activity
  • Laminin Binding
  • Protein Homodimerization Activity
  • Serine Hydrolase Activity

Biological Processes:

  • Acetylcholine Catabolic Process
  • Acetylcholine Catabolic Process In Synaptic Cleft
  • Amyloid Precursor Protein Metabolic Process
  • Cell Adhesion
  • Cell Proliferation
  • Dna Replication
  • Muscle Organ Development
  • Negative Regulation Of Synaptic Transmission, Cholinergic
  • Nervous System Development
  • Neurotransmitter Biosynthetic Process
  • Neurotransmitter Receptor Biosynthetic Process
  • Osteoblast Development
  • Phosphatidylcholine Biosynthetic Process
  • Positive Regulation Of Protein Secretion
  • Protein Tetramerization
  • Receptor Internalization
  • Regulation Of Receptor Recycling
  • Response To Wounding
  • Retina Development In Camera-Type Eye
  • Synapse Assembly

Drug Bank:

  • Ambenonium
  • Dimetacrine
  • Pyridostigmine
  • Choline
  • Decamethonium
  • Demecarium
  • Dipivefrin
  • Donepezil
  • Edrophonium
  • Galantamine
  • Gallamine Triethiodide
  • Isoflurophate
  • Mefloquine
  • Minaprine
  • Neostigmine
  • Pralidoxime
  • Rivastigmine
  • Tubocurarine
  • Acetylcholine
  • Ephedrine
  • Physostigmine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ACEE| Acetylcholine receptor subunit epsilon| Acetylcholinesterase| acetylcholinesterase isoform E4-E6| acetylcholinesterase-like protein| acetylcholinesterase T-subunit| acetylcholinesterase (Yt blood group)| apoptosis-related acetylcholinesterase| ARACHE| CB1_000518003| D623_10015186| glycolipid-anchored form of acetylcholinesterase| H920_01762| I79_023006| MDA_GLEAN10005722| n-ache| PAL_GLEAN10012067| TREES_T100020805| YT| Yt blood group| ziehharmonika| zim| ache

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