The Function of ACAN
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
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Protein names
Recommended name:
Aggrecan core proteinShort name:
CSPCPAlternative name(s):
Cartilage-specific proteoglycan core proteinChondroitin sulfate proteoglycan core protein 1
Chondroitin sulfate proteoglycan 1
- RS16942341 (ACAN) ??
- RS2280470 (ACAN) ??
- RS2351491 (ACAN) ??
- RS3817428 (ACAN) ??
- RS8041863 (ACAN) ??
- RS8042988 (ACAN) ??
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Top Gene-Substance Interactions
ACAN Interacts with These Diseases
| Disease | Score |
Substances That Increase ACAN
| Substances | Interaction | Organism | Category |
Substances That Decrease ACAN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Restricted to cartilages.
Developmental stage:
Expression was detected in chondrocytes throughout the developing skeleton.
Molecular Function:
- Extracellular Matrix Structural Constituent
- Hyaluronic Acid Binding
- Carbohydrate Binding
- Metal Ion Binding
Biological Processes:
- Skeletal System Development
- Proteolysis
- Cell Adhesion
- Central Nervous System Development
- Keratan Sulfate Biosynthetic Process
- Extracellular Matrix Disassembly
- Extracellular Matrix Organization
- Keratan Sulfate Catabolic Process