• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. ACAN

ACAN (Aggrecan)

Loading...

The Function of ACAN

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Aggrecan core protein

Short name:

CSPCP

Alternative name(s):

Cartilage-specific proteoglycan core protein
Chondroitin sulfate proteoglycan core protein 1
Chondroitin sulfate proteoglycan 1

ACAN SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS16942341 (ACAN) ??
  2. RS2280470 (ACAN) ??
  3. RS2351491 (ACAN) ??
  4. RS3817428 (ACAN) ??
  5. RS8041863 (ACAN) ??
  6. RS8042988 (ACAN) ??

Top Gene-Substance Interactions

ACAN Interacts with These Diseases

Disease Score

Substances That Increase ACAN

Substances Interaction Organism Category

Substances That Decrease ACAN

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • Egr-1
  • FOXC1
  • Sox9
  • HNF-3beta

Tissue specificity:

Restricted to cartilages.

Developmental stage:

Expression was detected in chondrocytes throughout the developing skeleton.

Molecular Function:

  • Carbohydrate Binding
  • Extracellular Matrix Structural Constituent
  • Hyaluronic Acid Binding
  • Metal Ion Binding

Biological Processes:

  • Cell Adhesion
  • Central Nervous System Development
  • Extracellular Matrix Disassembly
  • Extracellular Matrix Organization
  • Keratan Sulfate Biosynthetic Process
  • Keratan Sulfate Catabolic Process
  • Proteolysis
  • Skeletal System Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_02805| Agc| AGC1| agcan| aggrecan 1| aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)| aggrecan chondroitin sulfate CS2 domain| Aggrecan core protein| aggrecan core protein-like| aggrecan epidermal growth factor-like domain-1| aggrecan interglobular domain| aggrecan, structural proteoglycan of cartilage| Anapl_16348| AS27_00178| AS28_04999| b2b183Clo| cartilage aggregating proteoglycan| cartilage-specific proteoglycan core protein| CB1_001815001| chondroitin sulfate proteoglycan 1| chondroitin sulfate proteoglycan core protein| chondroitin sulfate proteoglycan core protein 1| cmd| CSPCP| cspg1| CSPGCP| D623_10004084| H920_03964| I79_021328| large aggregating proteoglycan| large aggregating proteoglycan, antigen| M91_02188| M959_09759| MDA_GLEAN10005318| MSK16| N300_13763| N301_04437| N303_10976| N306_12745| N308_02660| N309_08633| N310_13781| N320_07198| N321_13984| N326_07845| N332_08763| N334_13120| N335_01539| N340_14016| PAL_GLEAN10009473| PANDA_008243| proteoglycan core protein| sedk| TREES_T100018732| UY3_07594| xagc1| Y1Q_018920| Y956_09734| Z169_04109| acan

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved