The Function of ACADVL
Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.
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Protein names
Recommended name:
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialShort name:
VLCAD- RS2309689 (ACADVL) ??
- RS28934585 (ACADVL) ??
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Top Gene-Substance Interactions
ACADVL Interacts with These Diseases
| Disease | Score |
Substances That Increase ACADVL
| Substances | Interaction | Organism | Category |
Substances That Decrease ACADVL
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Fatty-Acyl-Coa Binding
- Acyl-Coa Dehydrogenase Activity
- Long-Chain-Acyl-Coa Dehydrogenase Activity
- Electron Carrier Activity
- Very-Long-Chain-Acyl-Coa Dehydrogenase Activity
- Flavin Adenine Dinucleotide Binding
- Oxidoreductase Activity, Acting On The Ch-Ch Group Of Donors, With A Flavin As Acceptor
Biological Processes:
- Temperature Homeostasis
- Fatty Acid Beta-Oxidation
- Energy Derivation By Oxidation Of Organic Compounds
- Epithelial Cell Differentiation
- Fatty Acid Beta-Oxidation Using Acyl-Coa Dehydrogenase
- Ire1-Mediated Unfolded Protein Response
- Very Long-Chain Fatty Acid Catabolic Process
- Negative Regulation Of Fatty Acid Biosynthetic Process
- Negative Regulation Of Fatty Acid Oxidation
- Lipid Homeostasis
- Regulation Of Cholesterol Metabolic Process