The Function of ACADM
Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
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Protein names
Recommended name:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialShort name:
MCAD- RS11161521 (ACADM) ??
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Top Gene-Substance Interactions
ACADM Interacts with These Diseases
| Disease | Score |
Substances That Increase ACADM
| Substances | Interaction | Organism | Category |
Substances That Decrease ACADM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Acyl-Coa Dehydrogenase Activity
- Electron Carrier Activity
- Fatty-Acyl-Coa Binding
- Flavin Adenine Dinucleotide Binding
- Identical Protein Binding
- Medium-Chain-Acyl-Coa Dehydrogenase Activity
- Oxidoreductase Activity, Acting On The Ch-Ch Group Of Donors, With A Flavin As Acceptor
Biological Processes:
- Carnitine Biosynthetic Process
- Carnitine Metabolic Process, Coa-Linked
- Fatty Acid Beta-Oxidation
- Fatty Acid Beta-Oxidation Using Acyl-Coa Dehydrogenase
- Lipid Homeostasis
- Medium-Chain Fatty Acid Catabolic Process
- Medium-Chain Fatty Acid Metabolic Process
- Oxidation-Reduction Process
Drug Bank:
- Flavin Adenine Dinucleotide