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  3. ACADM

ACADM (Acyl-CoA dehydrogenase, C-4 to C-12 straight chain)

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The Function of ACADM

Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

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Protein names

Recommended name:

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Short name:

MCAD

ACADM SNPs

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  1. RS11161521 (ACADM) ??

Top Gene-Substance Interactions

ACADM Interacts with These Diseases

Disease Score

Substances That Increase ACADM

Substances Interaction Organism Category

Substances That Decrease ACADM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Fatty acid metabolism
  • Valine, leucine and isoleucine degradation
  • PPAR signaling pathway
  • Propanoate metabolism
  • beta-Alanine metabolism

Molecular Function:

  • Acyl-Coa Dehydrogenase Activity
  • Electron Carrier Activity
  • Fatty-Acyl-Coa Binding
  • Flavin Adenine Dinucleotide Binding
  • Identical Protein Binding
  • Medium-Chain-Acyl-Coa Dehydrogenase Activity
  • Oxidoreductase Activity, Acting On The Ch-Ch Group Of Donors, With A Flavin As Acceptor

Biological Processes:

  • Carnitine Biosynthetic Process
  • Carnitine Metabolic Process, Coa-Linked
  • Fatty Acid Beta-Oxidation
  • Fatty Acid Beta-Oxidation Using Acyl-Coa Dehydrogenase
  • Lipid Homeostasis
  • Medium-Chain Fatty Acid Catabolic Process
  • Medium-Chain Fatty Acid Metabolic Process
  • Oxidation-Reduction Process

Drug Bank:

  • Flavin Adenine Dinucleotide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13621| ACAD1| acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain| Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain| acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, nuclear gene encoding mitochondrial protein| acyl-Coenzyme A dehydrogenase, medium chain| AS27_00341| AS28_09870| C-4 to C-12 straight chain acyl-coenzyme A dehydrogenase| D623_10032429| fb53e01| GW7_18083| H920_15413| I79_001847| M91_20105| MCAD| MCADH| medium-chain acyl-CoA dehydrogenase| medium-chain specific acyl-CoA dehydrogenase, mitochondrial| mitochondrial medium-chain specific acyl-Co dehydrogenase-like protein| N300_02932| N302_14806| N303_13294| N305_09461| N307_06482| N308_14245| N309_13737| N326_05270| N330_07306| N333_09554| N341_05210| PAL_GLEAN10023877| PANDA_005101| probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial| putative medium-chain specific acyl-CoA dehydrogenase, mitochondrial| testicular tissue protein Li 7| Y1Q_019428| Y956_08765| Z169_02975| acadm

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