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  3. ACAD8

ACAD8 (Acyl-CoA dehydrogenase family member 8)

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The Function of ACAD8

Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.

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Protein names

Recommended name:

Isobutyryl-CoA dehydrogenase, mitochondrial

Short name:

ARC42

Alternative name(s):

Activator-recruited cofactor 42 kDa component
Acyl-CoA dehydrogenase family member 8
ACAD-8

ACAD8 SNPs

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  1. RS478881 (ACAD8) ??

Top Gene-Substance Interactions

ACAD8 Interacts with These Diseases

Disease Score

Substances That Increase ACAD8

Substances Interaction Organism Category

Substances That Decrease ACAD8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • CUTL1
  • HOXA3
  • Pbx1a
  • Pax-6
  • MRF-2
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Valine, leucine and isoleucine degradation

Molecular Function:

  • Acyl-Coa Dehydrogenase Activity
  • Electron Carrier Activity
  • Fatty-Acyl-Coa Binding
  • Flavin Adenine Dinucleotide Binding
  • Oxidoreductase Activity, Acting On The Ch-Ch Group Of Donors, With A Flavin As Acceptor

Biological Processes:

  • Branched-Chain Amino Acid Catabolic Process
  • Fatty Acid Beta-Oxidation Using Acyl-Coa Dehydrogenase
  • Lipid Homeostasis
  • Lipid Metabolic Process
  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
  • Valine Catabolic Process

Drug Bank:

  • Flavin Adenine Dinucleotide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08696| ACAD-8| activator-recruited cofactor 42 kDa component| acyl-CoA dehydrogenase family, member 8| acyl-coenzyme A dehydrogenase family, member 8| Anapl_15539| ARC42| AS27_09026| AS28_02860| CB1_000614012| D623_10003681| GW7_11538| H920_01301| Isobutyryl-CoA dehydrogenase| Isobutyryl-CoA dehydrogenase, mitochondrial| M91_20052| M959_08917| N300_04856| N301_15851| N302_11094| N303_10856| N305_02084| N306_10329| N307_03277| N308_07827| N309_02307| N310_05871| N311_00166| N312_03000| N320_10014| N321_07900| N322_00347| N324_10295| N325_04692| N326_13406| N327_00357| N328_00207| N329_08880| N330_00123| N331_10420| N332_11884| N333_00143| N334_11985| N335_00257| N336_04540| N339_10195| N340_08951| N341_09086| PAL_GLEAN10006590| PANDA_005059| RGD1564209| UY3_13885| Y1Q_025764| Y956_07337| Z169_04244| acad8

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