The Function of ACAD8
Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
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Protein names
Recommended name:
Isobutyryl-CoA dehydrogenase, mitochondrialShort name:
ARC42Alternative name(s):
Activator-recruited cofactor 42 kDa componentAcyl-CoA dehydrogenase family member 8
ACAD-8
- RS478881 (ACAD8) ??
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Top Gene-Substance Interactions
ACAD8 Interacts with These Diseases
| Disease | Score |
Substances That Increase ACAD8
| Substances | Interaction | Organism | Category |
Substances That Decrease ACAD8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.
Molecular Function:
- Fatty-Acyl-Coa Binding
- Acyl-Coa Dehydrogenase Activity
- Electron Carrier Activity
- Flavin Adenine Dinucleotide Binding
- Oxidoreductase Activity, Acting On The Ch-Ch Group Of Donors, With A Flavin As Acceptor
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Valine Catabolic Process
- Lipid Metabolic Process
- Branched-Chain Amino Acid Catabolic Process
- Fatty Acid Beta-Oxidation Using Acyl-Coa Dehydrogenase
- Lipid Homeostasis
Drug Bank:
- Flavin Adenine Dinucleotide