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  3. ACACA

ACACA (Acetyl-CoA carboxylase alpha)

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The Function of ACACA

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

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Protein names

Recommended name:

Acetyl-CoA carboxylase 1

Short name:

ACC1

Alternative name(s):

ACC-alpha

ACACA SNPs

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  1. RS8081319 (ACACA) ??

Top Gene-Substance Interactions

ACACA Interacts with These Diseases

Disease Score

Substances That Increase ACACA

Substances Interaction Organism Category

Substances That Decrease ACACA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • C/EBPbeta
  • C/EBPalpha
  • E2F-1
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • AP-2gamma

Tissue specificity:

Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Insulin signaling pathway
  • Pyruvate metabolism
  • Fatty acid biosynthesis
  • Propanoate metabolism

Enzyme Regulation:

By phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.

Cofactor:

Binds 2 manganese ions per subunit.

Molecular Function:

  • Acetyl-Coa Carboxylase Activity
  • Atp Binding
  • Biotin Carboxylase Activity
  • Metal Ion Binding

Biological Processes:

  • Acetyl-Coa Metabolic Process
  • Biotin Metabolic Process
  • Carnitine Shuttle
  • Cellular Response To Prostaglandin E Stimulus
  • Fatty Acid Biosynthetic Process
  • Lipid Homeostasis
  • Long-Chain Fatty-Acyl-Coa Biosynthetic Process
  • Malonyl-Coa Biosynthetic Process
  • Multicellular Organismal Protein Metabolic Process
  • Positive Regulation Of Cellular Metabolic Process
  • Protein Homotetramerization
  • Tissue Homeostasis

Drug Bank:

  • Biotin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ACAC| ACACAD| acc| ACC1| ACCA| ACC-alpha| acetyl CoA carboxylase| acetyl-CoA carboxylase| Acetyl-CoA carboxylase 1| acetyl-CoA carboxylase 265| acetyl coenzyme A carboxylase alpha| acetyl-Coenzyme A carboxylase alpha| acetyl-Coenzyme A carboxylase alpha isoform 1 isoform 1-like protein| CB1_000121009| D623_10031022| EGK_08623| fj43d01| H920_06435| I79_021198| MDA_GLEAN10012119| PAL_GLEAN10019838| TREES_T100005537| acaca

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