The Function of ACACA
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
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Protein names
Recommended name:
Acetyl-CoA carboxylase 1Short name:
ACC1Alternative name(s):
ACC-alpha- RS8081319 (ACACA) ??
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Top Gene-Substance Interactions
ACACA Interacts with These Diseases
| Disease | Score |
Substances That Increase ACACA
| Substances | Interaction | Organism | Category |
Substances That Decrease ACACA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Gene Pathways:
Enzyme Regulation:
By phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.
Cofactor:
Binds 2 manganese ions per subunit.
Molecular Function:
Biological Processes:
- Tissue Homeostasis
- Acetyl-Coa Metabolic Process
- Fatty Acid Biosynthetic Process
- Biotin Metabolic Process
- Carnitine Shuttle
- Positive Regulation Of Cellular Metabolic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process
- Multicellular Organismal Protein Metabolic Process
- Protein Homotetramerization
- Lipid Homeostasis
- Cellular Response To Prostaglandin E Stimulus
- Malonyl-Coa Biosynthetic Process