The Function of ABHD6
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids.
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Protein names
Recommended name:
Monoacylglycerol lipase ABHD6Alternative name(s):
2-arachidonoylglycerol hydrolaseAbhydrolase domain-containing protein 6
Top Gene-Substance Interactions
Substances That Increase ABHD6
| Substances | Interaction | Organism | Category |
Substances That Decrease ABHD6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Acylglycerol Catabolic Process
- Long Term Synaptic Depression
- Negative Regulation Of Cell Migration
- Phospholipid Catabolic Process
- Positive Regulation Of Lipid Biosynthetic Process
- Regulation Of Endocannabinoid Signaling Pathway