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  3. ABCG8

ABCG8 (ATP binding cassette subfamily G member 8)

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Summary of ABCG8

The ABCG8 gene encodes sterolin-2, which makes up half of a protein called sterolin. Sterolin is involved in eliminating sterols, which are fatty components of plant-based foods that cannot be used by human cells. Sterolin also helps regulate levels of cholesterol (R).

Mutations can cause high cholesterol, anemia, and increase the risk of getting gallstones (R).

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The Function of ABCG8

Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Protein names

Recommended name:

ATP-binding cassette sub-family G member 8

Alternative name(s):

Sterolin-2

ABCG8 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11887534 (ABCG8) ??
  2. RS41360247 (ABCG8) ??
  3. RS4148211 (ABCG8) ??
  4. RS4148217 (ABCG8) ??
  5. RS4245791 (ABCG8) ??
  6. RS4299376 (ABCG8) ??
  7. RS4953023 (ABCG8) ??
  8. RS6544713 (ABCG8) ??
  9. RS6544718 (ABCG8) ??
  10. RS6756629 (ABCG8) ??
  11. RS72875462 (ABCG8) ??
  12. RS76866386 (ABCG8) ??

Top Gene-Substance Interactions

ABCG8 Interacts with These Diseases

Disease Score

Substances That Increase ABCG8

Substances Interaction Organism Category

Substances That Decrease ABCG8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-alpha

Tissue specificity:

Strongly expressed in the liver, lower levels in the small intestine and colon. Detectable in a wide variety of human tissues.

Gene Pathways:

  • Metabolism
  • Fat digestion and absorption
  • Bile secretion
  • Transmembrane transport of small molecules
  • ABC transporters

Caution:

Seems to have a defective ATP-binding region.

Molecular Function:

  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atp Binding
  • Cholesterol Transporter Activity
  • Protein Heterodimerization Activity

Biological Processes:

  • Cholesterol Efflux
  • Cholesterol Homeostasis
  • Excretion
  • Intestinal Cholesterol Absorption
  • Negative Regulation Of Intestinal Cholesterol Absorption
  • Negative Regulation Of Intestinal Phytosterol Absorption
  • Phospholipid Transport
  • Response To Nutrient
  • Sterol Transport
  • Transmembrane Transport

Drug Bank:

  • Ezetimibe
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| STSL| ABC transporter G family member 8| AS28_15058| ATP-binding cassette sub-family G member 8| ATP-binding cassette, sub-family G (WHITE), member 8| ATP-binding cassette, subfamily G (WHITE), member 8| ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)| CB1_000929006| EGK_05285| GBD4| GW7_03996| H920_18316| M91_11914| M959_02173| N301_04451| N303_07574| N305_00960| N307_14458| N308_02408| N309_11282| N310_04081| N311_02260| N320_03046| N321_14245| N322_12604| N324_03371| N325_04369| N326_05222| N328_03770| N329_05337| N330_05496| N332_04765| N333_11029| N335_03379| N339_05064| N340_13563| N341_11290| PAL_GLEAN10021297| PANDA_000194| sterolin 2| sterolin-2| TREES_T100004537| UY3_00155| Y1Q_003540| Z169_03122| abcg8

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