Summary of ABCG8
The ABCG8 gene encodes sterolin-2, which makes up half of a protein called sterolin. Sterolin is involved in eliminating sterols, which are fatty components of plant-based foods that cannot be used by human cells. Sterolin also helps regulate levels of cholesterol (R).
Mutations can cause high cholesterol, anemia, and increase the risk of getting gallstones (R).
The Function of ABCG8
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Protein names
Recommended name:
ATP-binding cassette sub-family G member 8Alternative name(s):
Sterolin-2- RS11887534 (ABCG8) ??
- RS41360247 (ABCG8) ??
- RS4148211 (ABCG8) ??
- RS4148217 (ABCG8) ??
- RS4245791 (ABCG8) ??
- RS4299376 (ABCG8) ??
- RS4953023 (ABCG8) ??
- RS6544713 (ABCG8) ??
- RS6544718 (ABCG8) ??
- RS6756629 (ABCG8) ??
- RS72875462 (ABCG8) ??
- RS76866386 (ABCG8) ??
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Top Gene-Substance Interactions
ABCG8 Interacts with These Diseases
| Disease | Score |
Substances That Increase ABCG8
| Substances | Interaction | Organism | Category |
Substances That Decrease ABCG8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Strongly expressed in the liver, lower levels in the small intestine and colon. Detectable in a wide variety of human tissues.
Gene Pathways:
Caution:
Seems to have a defective ATP-binding region.
Molecular Function:
- Atpase Activity, Coupled To Transmembrane Movement Of Substances
- Atp Binding
- Cholesterol Transporter Activity
- Protein Heterodimerization Activity
Biological Processes:
- Cholesterol Efflux
- Cholesterol Homeostasis
- Excretion
- Intestinal Cholesterol Absorption
- Negative Regulation Of Intestinal Cholesterol Absorption
- Negative Regulation Of Intestinal Phytosterol Absorption
- Phospholipid Transport
- Response To Nutrient
- Sterol Transport
- Transmembrane Transport