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  3. ABCG2

ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

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Summary of ABCG2

This gene encodes a protein that is part of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. It may play a major role in multi-drug resistance (R).

Also known as breast cancer resistance protein (BCRP).

It is able to export of porhyrin (PPIX) both from mitochondria to outside the cell, as well as heme. It may play an important role in the exclusion of foreign compounds from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.

It's better to have this gene increased most of the time. Exceptions: Chemotherapy , 10p Deletion Syndrome (Partial)
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Protein names

Recommended name:

ATP-binding cassette sub-family G member 2

Alternative name(s):

Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD antigen CD338

ABCG2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13120400 (ABCG2) ??
  2. RS1481012 (ABCG2) ??
  3. RS17731538 (ABCG2) ??
  4. RS2199936 (ABCG2) ??
  5. RS2231137 (ABCG2) ??
  6. RS2231142 (ABCG2) ??
  7. RS2622604 (ABCG2) ??
  8. RS2728124 (ABCG2) ??
  9. RS2728125 (ABCG2) ??
  10. RS3114018 (ABCG2) ??
  11. RS4148152 (ABCG2) ??
  12. RS4148155 (ABCG2) ??
  13. RS72552713 (ABCG2) ??

Top Gene-Substance Interactions

ABCG2 Interacts with These Diseases

Disease Score

Substances That Increase ABCG2

Substances Interaction Organism Category

Substances That Decrease ABCG2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • AP-1
  • Max
  • c-Jun
  • PPAR-gamma
  • RXR

Tissue specificity:

Highly expressed in placenta. Low expression in small intestine, liver and colon.

Gene Pathways:

  • Metabolism
  • Bile secretion
  • Transmembrane transport of small molecules
  • ABC transporters

Induction:

Up-regulated in brain tumors.

Molecular Function:

  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atp Binding
  • Heme Transporter Activity
  • Protein Homodimerization Activity
  • Transporter Activity
  • Xenobiotic-Transporting Atpase Activity

Biological Processes:

  • Cellular Iron Ion Homeostasis
  • Transport
  • Urate Metabolic Process
  • Cellular Response To Dexamethasone Stimulus
  • Drug Export
  • Embryonic Process Involved In Female Pregnancy
  • Response To Folic Acid
  • Response To Iron Ion

Drug Bank:

  • Afatinib
  • Alectinib
  • Cobimetinib
  • Conjugated Estrogens
  • Daclatasvir
  • Dronabinol
  • Erlotinib
  • Imatinib
  • Nilotinib
  • Buprenorphine
  • Cabazitaxel
  • Carboplatin
  • Cisplatin
  • Cladribine
  • Cobicistat
  • Cyclosporine
  • Dabrafenib
  • Dactinomycin
  • Dasatinib
  • Dexamethasone
  • Diethylstilbestrol
  • Docetaxel
  • Doxorubicin
  • Estradiol
  • Estrone
  • Ezetimibe
  • Fluorouracil
  • Folic Acid
  • Gefitinib
  • Glyburide
  • Hydrocortisone
  • Idelalisib
  • Irinotecan
  • Ivermectin
  • Leflunomide
  • Lenvatinib
  • Methotrexate
  • Mitoxantrone
  • Mycophenolate Mofetil
  • Nelfinavir
  • Novobiocin
  • Omeprazole
  • Lansoprazole
  • Rolapitant
  • Rosuvastatin
  • Vandetanib
  • Vemurafenib
  • Vismodegib
  • Oxaliplatin
  • Paclitaxel
  • Pantoprazole
  • Pazopanib
  • Pitavastatin
  • Pravastatin
  • Prazosin
  • Rabeprazole
  • Regorafenib
  • Riluzole
  • Riociguat
  • Ritonavir
  • Saquinavir
  • Sorafenib
  • Sulfasalazine
  • Sumatriptan
  • Sunitinib
  • Tamoxifen
  • Teniposide
  • Teriflunomide
  • Testosterone
  • Topotecan
  • Venlafaxine
  • Vincristine
  • Zafirlukast
  • Zidovudine
  • Apixaban
  • Clofarabine
  • Daunorubicin
  • Etoposide
  • Hesperetin
  • Lamivudine
  • Nitrofurantoin
  • Osimertinib
  • Ponatinib
  • Rilpivirine
  • Sofosbuvir
  • Telmisartan
  • Verapamil
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ABC transporter| A306_06574| ABC15| ABCG3| ABCP| AS27_05728| AS28_03141| ATP-binding cassette protein G2| ATP binding cassette subfamily G member 2| ATP-binding cassette sub-family G member 2| ATP-binding cassette, sub-family G, member 2| ATP-binding cassette sub-family G member 2-like protein| ATP-binding cassette sub-family G (WHITE) member 2| ATP-binding cassette, sub-family G (WHITE), member 2| ATP-binding cassette, subfamily G (WHITE), member 2| ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)| ATP-binding cassette superfamily G member 2 transporter| ATP-binding cassette superfamily G member 2 transporter protein| ATP binding cassette superfamily G number 2 transporter| ATP-binding cassette transporter G2| ATP-binding cassette transporter sub-family G member 2| ATP-binding cassette transporter subfamily G member 2| bcrp| BCRP1| BMDP| brain multidrug resistance protein| breast cancer resistance protein| breast cancer resistance protein 1 homolog| CD338| CDw338| EGK_21236| EST157481| GOUT1| H920_17793| M959_00821| mitoxantrone resistance-associated protein| mitoxantrone resistance protein 1| MRX| multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2| MXR| MXR1| MXR-1| N300_03084| N301_03957| N302_06065| N303_09481| N310_04993| N311_04824| N312_12746| N320_10347| N321_02592| N324_06788| N326_10767| N327_10800| N329_11148| N330_02987| N331_01479| N332_14210| N333_11379| N335_01796| N336_02590| N339_08194| N340_06245| PAL_GLEAN10010909| PANDA_001443| Placenta-specific ATP-binding cassette transporter| placenta specific MDR protein| TREES_T100011633| UAQTL1| urate exporter| Y956_11702| Z169_13681| abcg2

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