ABCG2 | SelfDecode | Genome Analysis

Summary of ABCG2

This gene encodes a protein that is part of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. It may play a major role in multi-drug resistance (R).

Also known as breast cancer resistance protein (BCRP).

It is able to export of porhyrin (PPIX) both from mitochondria to outside the cell, as well as heme. It may play an important role in the exclusion of foreign compounds from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.

It's better to have this gene increased most of the time. Exceptions: Chemotherapy , 10p Deletion Syndrome (Partial)

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Protein names

Recommended name:

ATP-binding cassette sub-family G member 2

Alternative name(s):

Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD antigen CD338

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Top Gene-Substance Interactions

ABCG2 Interacts with These Diseases

Disease	Score

Substances That Increase ABCG2

Category:

Substances	Interaction	Organism	Category

Substances That Decrease ABCG2

Category:

Substances	Interaction	Organism	Category

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Highly expressed in placenta. Low expression in small intestine, liver and colon.

Gene Pathways:

Induction:

Up-regulated in brain tumors.

Molecular Function:

Biological Processes:

Drug Bank:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ABC transporter| A306_06574| ABC15| ABCG3| ABCP| AS27_05728| AS28_03141| ATP-binding cassette protein G2| ATP binding cassette subfamily G member 2| ATP-binding cassette sub-family G member 2| ATP-binding cassette, sub-family G, member 2| ATP-binding cassette sub-family G member 2-like protein| ATP-binding cassette sub-family G (WHITE) member 2| ATP-binding cassette, sub-family G (WHITE), member 2| ATP-binding cassette, subfamily G (WHITE), member 2| ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)| ATP-binding cassette superfamily G member 2 transporter| ATP-binding cassette superfamily G member 2 transporter protein| ATP binding cassette superfamily G number 2 transporter| ATP-binding cassette transporter G2| ATP-binding cassette transporter sub-family G member 2| ATP-binding cassette transporter subfamily G member 2| bcrp| BCRP1| BMDP| brain multidrug resistance protein| breast cancer resistance protein| breast cancer resistance protein 1 homolog| CD338| CDw338| EGK_21236| EST157481| GOUT1| H920_17793| M959_00821| mitoxantrone resistance-associated protein| mitoxantrone resistance protein 1| MRX| multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2| MXR| MXR1| MXR-1| N300_03084| N301_03957| N302_06065| N303_09481| N310_04993| N311_04824| N312_12746| N320_10347| N321_02592| N324_06788| N326_10767| N327_10800| N329_11148| N330_02987| N331_01479| N332_14210| N333_11379| N335_01796| N336_02590| N339_08194| N340_06245| PAL_GLEAN10010909| PANDA_001443| Placenta-specific ATP-binding cassette transporter| placenta specific MDR protein| TREES_T100011633| UAQTL1| urate exporter| Y956_11702| Z169_13681| abcg2

ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

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