Summary of ABCC6
The ABCC6 gene encodes a protein called multidrug resistance-associated protein. It transports molecules across cell membranes, but there is not a lot of information about the molecules it transfers. It might stimulate the release of ATP or a substance that is involved in the breakdown of ATP (R).
Mutations might cause abnormal calcification in the blood vessels that carry blood from the heart to the rest of the body or in the fibers in skin and tissues (R).
The Function of ABCC6
Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein names
Recommended name:
Multidrug resistance-associated protein 6Short name:
MOAT-EAlternative name(s):
ATP-binding cassette sub-family C member 6Anthracycline resistance-associated protein
Multi-specific organic anion transporter E
- RS11861980 (ABCC6) ??
- RS150468 (ABCC6) ??
- RS212077 (ABCC6) ??
- RS2238472 (ABCC6) ??
- RS2856585 (ABCC6) ??
- RS3213473 (ABCC6) ??
- RS58694313 (ABCC6) ??
- RS63751325 (ABCC6) ??
- RS72653706 (ABCC6) ??
- RS7500834 (ABCC6) ??
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Top Gene-Substance Interactions
ABCC6 Interacts with These Diseases
| Disease | Score |
Substances That Increase ABCC6
| Substances | Interaction | Organism | Category |
Substances That Decrease ABCC6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in kidney and liver. Very low expression in other tissues.
Gene Pathways:
Induction:
Isoform 2 is induced by HBV x antigen upon hepatitis B viral infection.
Molecular Function:
- Atpase Activity, Coupled To Transmembrane Movement Of Substances
- Atpase-Coupled Anion Transmembrane Transporter Activity
- Atp Binding
- Transporter Activity
Biological Processes:
Drug Bank:
- Dactinomycin
- Daunorubicin
- Doxorubicin
- Indomethacin
- Probenecid
- Sulfinpyrazone
- Teniposide
- Vinblastine
- Cisplatin
- Etoposide