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  3. ABCC6

ABCC6 (ATP binding cassette subfamily C member 6)

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Summary of ABCC6

The ABCC6 gene encodes a protein called multidrug resistance-associated protein. It transports molecules across cell membranes, but there is not a lot of information about the molecules it transfers. It might stimulate the release of ATP or a substance that is involved in the breakdown of ATP (R). 

Mutations might cause abnormal calcification in the blood vessels that carry blood from the heart to the rest of the body or in the fibers in skin and tissues (R). 

0 users want this gene increased, 0 users want it decreased

The Function of ABCC6

Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.

Protein names

Recommended name:

Multidrug resistance-associated protein 6

Short name:

MOAT-E

Alternative name(s):

ATP-binding cassette sub-family C member 6
Anthracycline resistance-associated protein
Multi-specific organic anion transporter E

ABCC6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11861980 (ABCC6) ??
  2. RS150468 (ABCC6) ??
  3. RS212077 (ABCC6) ??
  4. RS2238472 (ABCC6) ??
  5. RS2856585 (ABCC6) ??
  6. RS3213473 (ABCC6) ??
  7. RS58694313 (ABCC6) ??
  8. RS63751325 (ABCC6) ??
  9. RS72653706 (ABCC6) ??
  10. RS7500834 (ABCC6) ??

Top Gene-Substance Interactions

ABCC6 Interacts with These Diseases

Disease Score

Substances That Increase ABCC6

Substances Interaction Organism Category

Substances That Decrease ABCC6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • GR
  • GR-alpha
  • GR-beta
  • Max
  • NF-kappaB1
  • Sp1

Tissue specificity:

Expressed in kidney and liver. Very low expression in other tissues.

Gene Pathways:

  • Transmembrane transport of small molecules
  • ABC transporters

Induction:

Isoform 2 is induced by HBV x antigen upon hepatitis B viral infection.

Molecular Function:

  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atpase-Coupled Anion Transmembrane Transporter Activity
  • Atp Binding
  • Transporter Activity

Biological Processes:

  • Transmembrane Transport
  • Transport
  • Visual Perception

Drug Bank:

  • Dactinomycin
  • Daunorubicin
  • Doxorubicin
  • Indomethacin
  • Probenecid
  • Sulfinpyrazone
  • Teniposide
  • Vinblastine
  • Cisplatin
  • Etoposide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Abcc1b| Multidrug resistance-associated protein 1| ABC34| anthracycline resistance-associated protein| ARA| AS27_15070| ATP-binding cassette, sub-family C (CFTR/MRP), member 6| ATP-binding cassette, subfamily C (CFTR/MRP), member 6| ATP-binding cassette sub-family C member 6| ATP-binding cassette, sub-family C, member 6| CB1_000394021| D623_10032214| DCC| dyscalc| Dyscalc1| EST349056| GACI2| H920_17936| I79_020938| liver multidrug resistance-associated protein 6| M91_01935| MDA_GLEAN10012918| mlp1| MLP-1| moate| MOAT-E| mrp6| MRP-like protein 1| Multidrug resistance-associated protein 6| multi-specific organic anion transporter E| N303_11863| N307_05917| N309_05723| N311_06947| N321_01404| N324_07791| N326_12092| N327_09957| N329_09170| N330_00596| N331_04368| N333_09641| N341_11336| PAL_GLEAN10009744| PANDA_016753| PXE| PXE1| TREES_T100018427| URG7| URG7 protein| abcc6

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