Summary of ABCC2
The ABCC2 gene encodes a protein called multidrug resistance protein 2 (MRP2). It is involved in the transport of substances out of cells and is mostly found in the liver, kidneys, intestine, and placenta. MRP2 clears certain drugs from organs and tissues, playing a part in drug metabolism (R).
Mutations in this gene can cause jaundice and cancer (R).
It's better to have this gene increased
most of the time.
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Protein names
Recommended name:
Canalicular multispecific organic anion transporter 1Alternative name(s):
ATP-binding cassette sub-family C member 2Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2
- RS17222723 (ABCC2) ??
- RS2273697 (ABCC2) ??
- RS3740065 (ABCC2) ??
- RS3740066 (ABCC2) ??
- RS717620 (ABCC2) ??
- RS8187710 (ABCC2) ??
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Top Gene-Substance Interactions
ABCC2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ABCC2
| Substances | Interaction | Organism | Category |
Substances That Decrease ABCC2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Molecular Function:
- Atp Binding
- Organic Anion Transmembrane Transporter Activity
- Bilirubin Transmembrane Transporter Activity
- Atpase Activity, Coupled To Transmembrane Movement Of Substances
- Atpase-Coupled Anion Transmembrane Transporter Activity
Biological Processes:
- Transport
- Drug Transmembrane Transport
- Response To Oxidative Stress
- Response To Heat
- Prostaglandin Transport
- Cellular Chloride Ion Homeostasis
- Response To Methotrexate
- Response To Estrogen
- Response To Arsenic-Containing Substance
- Response To Steroid Hormone
- Transmembrane Transport
- Thyroid Hormone Transport
Drug Bank:
- Probenecid
- Adenosine Triphosphate
- Aminohippurate
- Conjugated Estrogens
- Gadoxetate
- Levetiracetam
- Arsenic Trioxide
- Atorvastatin
- Avibactam
- Canagliflozin
- Carbamazepine
- Carboplatin
- Cholic Acid
- Cisplatin
- Cyclosporine
- Daunorubicin
- Dexamethasone
- Docetaxel
- Doxorubicin
- Eluxadoline
- Ethinyl Estradiol
- Etoposide
- Ezetimibe
- Furosemide
- Glutathione
- Glyburide
- Indinavir
- Indomethacin
- Irinotecan
- Ivermectin
- Leucovorin
- Lomefloxacin
- Lovastatin
- Methotrexate
- Nifedipine
- Norgestimate
- Ofloxacin
- Olmesartan
- Oxaliplatin
- Paclitaxel
- Phenobarbital
- Phenytoin
- Pranlukast
- Rifampicin
- Vasopressin
- Reserpine
- Saquinavir
- Simvastatin
- Sorafenib
- Sparfloxacin
- Spironolactone
- Sulfasalazine
- Sunitinib
- Tamoxifen
- Telmisartan
- Tenofovir
- Ursodeoxycholic Acid
- Verapamil
- Vinblastine
- Vincristine
- Pravastatin
- Clotrimazole
- Eprosartan
- Fusidic Acid
- Lamivudine
- Mycophenolate Mofetil
- Pitavastatin
- Quinidine
- Ritonavir
- Sulfinpyrazone
- Tetrahydrofolic Acid