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  3. ABCC2

ABCC2 (ATP binding cassette subfamily C member 2)

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Summary of ABCC2

The ABCC2 gene encodes a protein called multidrug resistance protein 2 (MRP2). It is involved in the transport of substances out of cells and is mostly found in the liver, kidneys, intestine, and placenta. MRP2 clears certain drugs from organs and tissues, playing a part in drug metabolism (R). 

Mutations in this gene can cause jaundice and cancer (R). 

It's better to have this gene increased most of the time.
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Protein names

Recommended name:

Canalicular multispecific organic anion transporter 1

Alternative name(s):

ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2

ABCC2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17222723 (ABCC2) ??
  2. RS2273697 (ABCC2) ??
  3. RS3740065 (ABCC2) ??
  4. RS3740066 (ABCC2) ??
  5. RS717620 (ABCC2) ??
  6. RS8187710 (ABCC2) ??

Top Gene-Substance Interactions

ABCC2 Interacts with These Diseases

Disease Score

Substances That Increase ABCC2

Substances Interaction Organism Category

Substances That Decrease ABCC2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • CAR
  • PXR
  • FXR
  • RXR-alpha
  • RAR-alpha

Tissue specificity:

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Gene Pathways:

  • Bile secretion
  • Transmembrane transport of small molecules
  • ABC transporters

Molecular Function:

  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atpase-Coupled Anion Transmembrane Transporter Activity
  • Atp Binding
  • Bilirubin Transmembrane Transporter Activity
  • Organic Anion Transmembrane Transporter Activity

Biological Processes:

  • Cellular Chloride Ion Homeostasis
  • Drug Transmembrane Transport
  • Prostaglandin Transport
  • Response To Arsenic-Containing Substance
  • Response To Estrogen
  • Response To Heat
  • Response To Methotrexate
  • Response To Oxidative Stress
  • Response To Steroid Hormone
  • Thyroid Hormone Transport
  • Transmembrane Transport
  • Transport

Drug Bank:

  • Probenecid
  • Adenosine Triphosphate
  • Aminohippurate
  • Conjugated Estrogens
  • Gadoxetate
  • Levetiracetam
  • Arsenic Trioxide
  • Atorvastatin
  • Avibactam
  • Canagliflozin
  • Carbamazepine
  • Carboplatin
  • Cholic Acid
  • Cisplatin
  • Cyclosporine
  • Daunorubicin
  • Dexamethasone
  • Docetaxel
  • Doxorubicin
  • Eluxadoline
  • Ethinyl Estradiol
  • Etoposide
  • Ezetimibe
  • Furosemide
  • Glutathione
  • Glyburide
  • Indinavir
  • Indomethacin
  • Irinotecan
  • Ivermectin
  • Leucovorin
  • Lomefloxacin
  • Lovastatin
  • Methotrexate
  • Nifedipine
  • Norgestimate
  • Ofloxacin
  • Olmesartan
  • Oxaliplatin
  • Paclitaxel
  • Phenobarbital
  • Phenytoin
  • Pranlukast
  • Rifampicin
  • Vasopressin
  • Reserpine
  • Saquinavir
  • Simvastatin
  • Sorafenib
  • Sparfloxacin
  • Spironolactone
  • Sulfasalazine
  • Sunitinib
  • Tamoxifen
  • Telmisartan
  • Tenofovir
  • Ursodeoxycholic Acid
  • Verapamil
  • Vinblastine
  • Vincristine
  • Pravastatin
  • Clotrimazole
  • Eprosartan
  • Fusidic Acid
  • Lamivudine
  • Mycophenolate Mofetil
  • Pitavastatin
  • Quinidine
  • Ritonavir
  • Sulfinpyrazone
  • Tetrahydrofolic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| multidrug resistance protein 2| A306_06127| ABC30| Anapl_06791| AS27_02653| AS28_07232| ATP-binding cassette, sub-family C (CFTR/MRP), member 2| ATP-binding cassette, subfamily C (CFTR/MRP), member 2| ATP-binding cassette sub-family C member 2| ATP-binding cassette, sub-family C, member 2| calicular multispecific organic anion transporter| canalicular multidrug resistance protein| Canalicular multispecific organic anion transporter 1| cmoat| cmrp| cMrp2/cMoat canalicular apical conjugate export pump| D623_10025674| DJS| EBCR| Epithelial basolateral chloride conductance regulator| GW7_13734| H920_11425| M959_09933| MDA_GLEAN10023409| mrp| mrp2| multidrug resistance associated protein 2| Multidrug resistance-associated protein 2| multidrug resistance-associated protein member 2| multidrug resistance-associated protein Mrp2| multidrug resistance protein MRP2| multi-drug resistance related transporter 2| N300_12542| N302_13537| N303_14154| N305_05485| N306_09814| N307_08730| N308_08998| N309_10776| N310_10496| N311_08180| N312_13339| N320_06484| N321_05980| N322_10584| N324_01463| N326_05636| N328_04096| N329_01204| N331_05116| N332_12219| N333_04385| N334_07142| N335_08306| N336_06176| N341_06014| PAL_GLEAN10018281| PANDA_013643| TREES_T100012310| UY3_06362| abcc2

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