ABCB1 | SelfDecode | Genome Analysis

Summary of ABCB1

ABCB1 encodes proteins that transport various molecules across extra- and intra-cellular membranes. It is involved in multidrug resistance and also helps as a transporter in the blood brain barrier (R).

It is associated with warfarin resistance and bowel diseases (R).

It's better to have this gene increased most of the time. Exceptions: Chemotherapy

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The Function of ABCB1

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Protein names

Recommended name:

Multidrug resistance protein 1

Alternative name(s):

ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD antigen CD243

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Top Gene-Substance Interactions

ABCB1 Interacts with These Diseases

Disease	Score

Substances That Increase ABCB1

Category:

Substances	Interaction	Organism	Category

Substances That Decrease ABCB1

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Substances	Interaction	Organism	Category

Advanced Summary

ABCB1 is a gene that codes for P-glycoprotein 1. P-glycoprotein-1 is a cell-membrane protein responsible for transporting materials across the cell membrane [R].

P-glycoprotein 1 (Pgp) is an energy-dependent pump, meaning it requires ATP to actively transport materials across the cell membrane. Called an efflux pump, it uses ATP to pump unwanted or harmful substances out of the cell [R].

PGP is part of a large family of proteins called ATP-binding cassette (ABC) transporters. ABC transporters are cell membrane proteins that use ATP hydrolysis to pump substrates across their concentration gradients [R].

PGP exhibits broad substrate specificity, which is why it is associated with multidrug resistance [R].

PGP is found in areas of excretion or protection, such as intestinal epithelium, liver cells, kidneys, and in the capillary endothelial cells of the blood-brain and blood-testis barriers, where it pumps toxins out for disposal [R].

By pumping out toxins and decreasing the buildup of anticancer drugs in the cell, PGP contributes to the development of multidrug resistance to cancer treatments [R,R].

Variations in the ABCB1 gene result in a higher susceptibility to Inflammatory Bowel Disease [R].

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Expressed in liver, kidney, small intestine and brain.

Gene Pathways:

Molecular Function:

Biological Processes:

Drug Bank:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

ABCB1 (ATP binding cassette subfamily B member 1)

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