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  3. ABCB1

ABCB1 (ATP binding cassette subfamily B member 1)

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Summary of ABCB1

ABCB1 encodes proteins that transport various molecules across extra- and intra-cellular membranes. It is involved in multidrug resistance and also helps as a transporter in the blood brain barrier (R). 

It is associated with warfarin resistance and bowel diseases (R).

It's better to have this gene increased most of the time. Exceptions: Chemotherapy
0 users want this gene increased, 0 users want it decreased

The Function of ABCB1

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Protein names

Recommended name:

Multidrug resistance protein 1

Alternative name(s):

ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD antigen CD243

ABCB1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10248420 (ABCB1) ??
  2. RS10264856 (ABCB1) ??
  3. RS10276036 (ABCB1) ??
  4. RS10280101 (ABCB1) ??
  5. RS1128503 (ABCB1) ??
  6. RS11983225 (ABCB1) ??
  7. RS1202184 (ABCB1) ??
  8. RS1202186 (ABCB1) ??
  9. RS12720067 (ABCB1) ??
  10. RS13233308 (ABCB1) ??
  11. RS2032583 (ABCB1) ??
  12. RS2157926 (ABCB1) ??
  13. RS2188524 (ABCB1) ??
  14. RS2214102 (ABCB1) ??
  15. RS2229107 (ABCB1) ??
  16. RS2229109 (ABCB1) ??
  17. RS2235015 (ABCB1) ??
  18. RS2235035 (ABCB1) ??
  19. RS2235040 (ABCB1) ??
  20. RS2235046 (ABCB1) ??
  21. RS2235067 (ABCB1) ??
  22. RS28364274 (ABCB1) ??
  23. RS3213619 (ABCB1) ??
  24. RS3842 (ABCB1) ??
  25. RS4148739 (ABCB1) ??
  26. RS4148740 (ABCB1) ??
  27. RS7787082 (ABCB1) ??
  28. RS9282564 (ABCB1) ??

Top Gene-Substance Interactions

ABCB1 Interacts with These Diseases

Disease Score

Substances That Increase ABCB1

Substances Interaction Organism Category

Substances That Decrease ABCB1

Substances Interaction Organism Category

Advanced Summary

ABCB1 is a gene that codes for P-glycoprotein 1.  P-glycoprotein-1 is a cell-membrane protein responsible for transporting materials across the cell membrane [R].

P-glycoprotein 1 (Pgp) is an energy-dependent pump, meaning it requires ATP to actively transport materials across the cell membrane.  Called an efflux pump, it uses ATP to pump unwanted or harmful substances out of the cell [R].

PGP is part of a large family of proteins called ATP-binding cassette (ABC) transporters.  ABC transporters are cell membrane proteins that use ATP hydrolysis to pump substrates across their concentration gradients [R].  

PGP exhibits broad substrate specificity, which is why it is associated with multidrug resistance [R].

PGP is found in areas of excretion or protection, such as intestinal epithelium, liver cells, kidneys, and in the capillary endothelial cells of the blood-brain and blood-testis barriers, where it pumps toxins out for disposal [R].

By pumping out toxins and decreasing the buildup of anticancer drugs in the cell, PGP contributes to the development of multidrug resistance to cancer treatments [R,R].

Variations in the ABCB1 gene result in a higher susceptibility to Inflammatory Bowel Disease [R].

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • C/EBPbeta
  • Sp1
  • AML1a

Tissue specificity:

Expressed in liver, kidney, small intestine and brain.

Gene Pathways:

  • Metabolism
  • Bile secretion
  • Transmembrane transport of small molecules
  • ABC transporters

Molecular Function:

  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atp Binding
  • Ceramide-Translocating Atpase Activity
  • Phosphatidylcholine-Translocating Atpase Activity
  • Phosphatidylethanolamine-Translocating Atpase Activity
  • Transporter Activity
  • Xenobiotic-Transporting Atpase Activity

Biological Processes:

  • Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class Ib Via Er Pathway, Tap-Dependent
  • Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class I Via Er Pathway, Tap-Dependent
  • Antigen Processing And Presentation Of Exogenous Protein Antigen Via Mhc Class Ib, Tap-Dependent
  • Ceramide Translocation
  • G2/M Transition Of Mitotic Cell Cycle
  • Phospholipid Translocation
  • Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via Mhc Class I
  • Stem Cell Proliferation
  • Transmembrane Transport
  • Transport

Drug Bank:

  • Acetaminophen
  • Acetylsalicylic Acid
  • Adenosine Triphosphate
  • Afatinib
  • Alectinib
  • Aminohippurate
  • Atazanavir
  • Boceprevir
  • Brentuximab Vedotin
  • Captopril
  • Clomifene
  • Cobimetinib
  • Conjugated Estrogens
  • Dabigatran Etexilate
  • Daclatasvir
  • Dapagliflozin
  • Dronabinol
  • Enzalutamide
  • Erlotinib
  • Fidaxomicin
  • Flupentixol
  • Gramicidin D
  • Imatinib
  • Isavuconazonium
  • Albendazole
  • Alfentanil
  • Alitretinoin
  • Amantadine
  • Ambrisentan
  • Amitriptyline
  • Amlodipine
  • Amprenavir
  • Amsacrine
  • Apixaban
  • Astemizole
  • Atenolol
  • Atorvastatin
  • Axitinib
  • Azelastine
  • Bepridil
  • Betamethasone
  • Biperiden
  • Bosutinib
  • Buprenorphine
  • Buspirone
  • Cabazitaxel
  • Caffeine
  • Canagliflozin
  • Candesartan
  • Carfilzomib
  • Carvedilol
  • Caspofungin
  • Ceritinib
  • Chloroquine
  • Chlorpropamide
  • Chlorprothixene
  • Cholic Acid
  • Cilazapril
  • Cimetidine
  • Ciprofloxacin
  • Cisplatin
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonidine
  • Clotrimazole
  • Clozapine
  • Cobicistat
  • Colchicine
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Dactinomycin
  • Dasatinib
  • Daunorubicin
  • Debrisoquin
  • Desloratadine
  • Dexamethasone
  • Dextromethorphan
  • Diazepam
  • Diclofenac
  • Digitoxin
  • Digoxin
  • Dihydroergotamine
  • Diltiazem
  • Dipyridamole
  • Docetaxel
  • Domperidone
  • Doxepin
  • Doxorubicin
  • Dronedarone
  • Edoxaban
  • Enalapril
  • Epinastine
  • Ergonovine
  • Ergotamine
  • Estradiol
  • Estramustine
  • Estriol
  • Estrone
  • Ethinyl Estradiol
  • Etoposide
  • Etravirine
  • Felodipine
  • Fentanyl
  • Fesoterodine
  • Fexofenadine
  • Fluconazole
  • Fluphenazine
  • Flurazepam
  • Fluticasone Furoate
  • Fluvoxamine
  • Gefitinib
  • Glyburide
  • Haloperidol
  • Hydrocortisone
  • Ibuprofen
  • Idelalisib
  • Indacaterol
  • Indinavir
  • Indomethacin
  • Irinotecan
  • Ivacaftor
  • Ivermectin
  • Ketamine
  • Ketazolam
  • Ketoconazole
  • Benzocaine
  • Levetiracetam
  • Levomilnacipran
  • Liothyronine
  • Liotrix
  • Lomitapide
  • Nilotinib
  • Norethisterone
  • Rifampicin
  • Rolapitant
  • Scopolamine
  • Sitagliptin
  • Umeclidinium
  • Vecuronium
  • Vismodegib
  • Lamotrigine
  • Lenalidomide
  • Lenvatinib
  • Levofloxacin
  • Levothyroxine
  • Lidocaine
  • Linagliptin
  • Loperamide
  • Lopinavir
  • Loratadine
  • Losartan
  • Mannitol
  • Maprotiline
  • Mebendazole
  • Mefloquine
  • Meprobamate
  • Methadone
  • Methotrexate
  • Methylprednisolone
  • Miconazole
  • Mifepristone
  • Mirabegron
  • Mitomycin
  • Mitoxantrone
  • Morphine
  • Nadolol
  • Naloxone
  • Naltrexone
  • Nefazodone
  • Nelfinavir
  • Neostigmine
  • Nifedipine
  • Nintedanib
  • Nisoldipine
  • Nitrazepam
  • Nizatidine
  • Olanzapine
  • Omeprazole
  • Osimertinib
  • Paclitaxel
  • Pantoprazole
  • Paroxetine
  • Pazopanib
  • Perindopril
  • Phenobarbital
  • Phenytoin
  • Pitavastatin
  • Pomalidomide
  • Ponatinib
  • Posaconazole
  • Pravastatin
  • Prazosin
  • Prednisone
  • Probenecid
  • Progesterone
  • Promethazine
  • Propafenone
  • Propranolol
  • Quetiapine
  • Quinacrine
  • Quinidine
  • Quinine
  • Ranitidine
  • Regorafenib
  • Reserpine
  • Rilpivirine
  • Risperidone
  • Rivaroxaban
  • Romidepsin
  • Roxithromycin
  • Salicylic Acid
  • Saquinavir
  • Selexipag
  • Sertraline
  • Silodosin
  • Simeprevir
  • Sirolimus
  • Sofosbuvir
  • Sorafenib
  • Sparfloxacin
  • Spironolactone
  • Streptozocin
  • Sumatriptan
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telaprevir
  • Temsirolimus
  • Terazosin
  • Testosterone
  • Ticagrelor
  • Timolol
  • Tolvaptan
  • Toremifene
  • Trazodone
  • Trifluoperazine
  • Triflupromazine
  • Trimethoprim
  • Trimipramine
  • Troleandomycin
  • Venlafaxine
  • Verapamil
  • Vinblastine
  • Vincristine
  • Voacamine
  • Zidovudine
  • Metoprolol
  • Lansoprazole
  • Acebutolol
  • Ado-Trastuzumab Emtansine
  • Amiodarone
  • Arsenic Trioxide
  • Azithromycin
  • Bromocriptine
  • Carbamazepine
  • Chlorpromazine
  • Citalopram
  • Clopidogrel
  • Cyclophosphamide
  • Desipramine
  • Diethylstilbestrol
  • Doxazosin
  • Eletriptan
  • Erythromycin
  • Ezetimibe
  • Fluoxetine
  • Gemcitabine
  • Imipramine
  • Itraconazole
  • Lamivudine
  • Lapatinib
  • Lovastatin
  • Megestrol Acetate
  • Midazolam
  • Mycophenolate Mofetil
  • Nicardipine
  • Nitrendipine
  • Panobinostat
  • Pimozide
  • Prednisolone
  • Protriptyline
  • Reboxetine
  • Ritonavir
  • Selegiline
  • Simvastatin
  • Sulfinpyrazone
  • Telmisartan
  • Topotecan
  • Ulipristal
  • Vinorelbine
  • Lisinopril
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ABC20| ABCB| ABCB1a| ABCB1LB| Abcb4| ABC transporter protein| ATP-binding cassette carrier B1| ATP-binding cassette, sub-family B (MDR/TAP), member 1| ATP-binding cassette, sub-family B (MDR/TAP), member 1A| ATP-binding cassette, sub-family B (MDR/TAP), member 1-like B| ATP-binding cassette, sub-family B (MDR/TAP), member 4| ATP-binding cassette sub-family B member 1| ATP-binding cassette, sub-family B , member 1| bovine P-glycoprotein| CD243| CLCS| CMDR1| colchicin sensitivity| D623_10033838| doxorubicin resistance| egg permeability glycoprotein| GP170| MDR1| MDR1-like/ABCB1-like| member 1| member 4| multidrug resistance p-glycoprotein| multi-drug resistance P-glycoprotein 1| multi-drug resistance protein 1| multidrug resistance protein 1| multidrug resistance protein-1| multidrug resistance protein 1-like protein| multidrug transporter| multidrug transporter P-glycoprotein| multixenobiotic transporter| N302_03048| PAL_GLEAN10013639| PANDA_001851| P glycoprotein| P-glycoprotein| P-glycoprotein 1| P-glycoprotein class IA| Pgp| P-GP| PGP1| Pgp1A| PGY1| SpABCB1, efflux transporter| subfamily B| sub-family B (MDR/TAP)| TREES_T100015165| UY3_16388| abcb1

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