Summary of ABCB1
ABCB1 encodes proteins that transport various molecules across extra- and intra-cellular membranes. It is involved in multidrug resistance and also helps as a transporter in the blood brain barrier (R).
It is associated with warfarin resistance and bowel diseases (R).
The Function of ABCB1
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Protein names
Recommended name:
Multidrug resistance protein 1Alternative name(s):
ATP-binding cassette sub-family B member 1P-glycoprotein 1
CD antigen CD243
- RS10248420 (ABCB1) ??
- RS10264856 (ABCB1) ??
- RS10276036 (ABCB1) ??
- RS10280101 (ABCB1) ??
- RS1128503 (ABCB1) ??
- RS11983225 (ABCB1) ??
- RS1202184 (ABCB1) ??
- RS1202186 (ABCB1) ??
- RS12720067 (ABCB1) ??
- RS13233308 (ABCB1) ??
- RS2032583 (ABCB1) ??
- RS2157926 (ABCB1) ??
- RS2188524 (ABCB1) ??
- RS2214102 (ABCB1) ??
- RS2229107 (ABCB1) ??
- RS2229109 (ABCB1) ??
- RS2235015 (ABCB1) ??
- RS2235035 (ABCB1) ??
- RS2235040 (ABCB1) ??
- RS2235046 (ABCB1) ??
- RS2235067 (ABCB1) ??
- RS28364274 (ABCB1) ??
- RS3213619 (ABCB1) ??
- RS3842 (ABCB1) ??
- RS4148739 (ABCB1) ??
- RS4148740 (ABCB1) ??
- RS7787082 (ABCB1) ??
- RS9282564 (ABCB1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ABCB1 Interacts with These Diseases
Disease | Score |
Substances That Increase ABCB1
Substances | Interaction | Organism | Category |
Substances That Decrease ABCB1
Substances | Interaction | Organism | Category |
Advanced Summary
ABCB1 is a gene that codes for P-glycoprotein 1. P-glycoprotein-1 is a cell-membrane protein responsible for transporting materials across the cell membrane [R].
P-glycoprotein 1 (Pgp) is an energy-dependent pump, meaning it requires ATP to actively transport materials across the cell membrane. Called an efflux pump, it uses ATP to pump unwanted or harmful substances out of the cell [R].
PGP is part of a large family of proteins called ATP-binding cassette (ABC) transporters. ABC transporters are cell membrane proteins that use ATP hydrolysis to pump substrates across their concentration gradients [R].
PGP exhibits broad substrate specificity, which is why it is associated with multidrug resistance [R].
PGP is found in areas of excretion or protection, such as intestinal epithelium, liver cells, kidneys, and in the capillary endothelial cells of the blood-brain and blood-testis barriers, where it pumps toxins out for disposal [R].
By pumping out toxins and decreasing the buildup of anticancer drugs in the cell, PGP contributes to the development of multidrug resistance to cancer treatments [R,R].
Variations in the ABCB1 gene result in a higher susceptibility to Inflammatory Bowel Disease [R].
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in liver, kidney, small intestine and brain.
Gene Pathways:
Molecular Function:
- Atpase Activity, Coupled To Transmembrane Movement Of Substances
- Atp Binding
- Ceramide-Translocating Atpase Activity
- Phosphatidylcholine-Translocating Atpase Activity
- Phosphatidylethanolamine-Translocating Atpase Activity
- Transporter Activity
- Xenobiotic-Transporting Atpase Activity
Biological Processes:
- Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class Ib Via Er Pathway, Tap-Dependent
- Antigen Processing And Presentation Of Endogenous Peptide Antigen Via Mhc Class I Via Er Pathway, Tap-Dependent
- Antigen Processing And Presentation Of Exogenous Protein Antigen Via Mhc Class Ib, Tap-Dependent
- Ceramide Translocation
- G2/M Transition Of Mitotic Cell Cycle
- Phospholipid Translocation
- Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via Mhc Class I
- Stem Cell Proliferation
- Transmembrane Transport
- Transport
Drug Bank:
- Acetaminophen
- Acetylsalicylic Acid
- Adenosine Triphosphate
- Afatinib
- Alectinib
- Aminohippurate
- Atazanavir
- Boceprevir
- Brentuximab Vedotin
- Captopril
- Clomifene
- Cobimetinib
- Conjugated Estrogens
- Dabigatran Etexilate
- Daclatasvir
- Dapagliflozin
- Dronabinol
- Enzalutamide
- Erlotinib
- Fidaxomicin
- Flupentixol
- Gramicidin D
- Imatinib
- Isavuconazonium
- Albendazole
- Alfentanil
- Alitretinoin
- Amantadine
- Ambrisentan
- Amitriptyline
- Amlodipine
- Amprenavir
- Amsacrine
- Apixaban
- Astemizole
- Atenolol
- Atorvastatin
- Axitinib
- Azelastine
- Bepridil
- Betamethasone
- Biperiden
- Bosutinib
- Buprenorphine
- Buspirone
- Cabazitaxel
- Caffeine
- Canagliflozin
- Candesartan
- Carfilzomib
- Carvedilol
- Caspofungin
- Ceritinib
- Chloroquine
- Chlorpropamide
- Chlorprothixene
- Cholic Acid
- Cilazapril
- Cimetidine
- Ciprofloxacin
- Cisplatin
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonidine
- Clotrimazole
- Clozapine
- Cobicistat
- Colchicine
- Crizotinib
- Cyclosporine
- Dabrafenib
- Dactinomycin
- Dasatinib
- Daunorubicin
- Debrisoquin
- Desloratadine
- Dexamethasone
- Dextromethorphan
- Diazepam
- Diclofenac
- Digitoxin
- Digoxin
- Dihydroergotamine
- Diltiazem
- Dipyridamole
- Docetaxel
- Domperidone
- Doxepin
- Doxorubicin
- Dronedarone
- Edoxaban
- Enalapril
- Epinastine
- Ergonovine
- Ergotamine
- Estradiol
- Estramustine
- Estriol
- Estrone
- Ethinyl Estradiol
- Etoposide
- Etravirine
- Felodipine
- Fentanyl
- Fesoterodine
- Fexofenadine
- Fluconazole
- Fluphenazine
- Flurazepam
- Fluticasone Furoate
- Fluvoxamine
- Gefitinib
- Glyburide
- Haloperidol
- Hydrocortisone
- Ibuprofen
- Idelalisib
- Indacaterol
- Indinavir
- Indomethacin
- Irinotecan
- Ivacaftor
- Ivermectin
- Ketamine
- Ketazolam
- Ketoconazole
- Benzocaine
- Levetiracetam
- Levomilnacipran
- Liothyronine
- Liotrix
- Lomitapide
- Nilotinib
- Norethisterone
- Rifampicin
- Rolapitant
- Scopolamine
- Sitagliptin
- Umeclidinium
- Vecuronium
- Vismodegib
- Lamotrigine
- Lenalidomide
- Lenvatinib
- Levofloxacin
- Levothyroxine
- Lidocaine
- Linagliptin
- Loperamide
- Lopinavir
- Loratadine
- Losartan
- Mannitol
- Maprotiline
- Mebendazole
- Mefloquine
- Meprobamate
- Methadone
- Methotrexate
- Methylprednisolone
- Miconazole
- Mifepristone
- Mirabegron
- Mitomycin
- Mitoxantrone
- Morphine
- Nadolol
- Naloxone
- Naltrexone
- Nefazodone
- Nelfinavir
- Neostigmine
- Nifedipine
- Nintedanib
- Nisoldipine
- Nitrazepam
- Nizatidine
- Olanzapine
- Omeprazole
- Osimertinib
- Paclitaxel
- Pantoprazole
- Paroxetine
- Pazopanib
- Perindopril
- Phenobarbital
- Phenytoin
- Pitavastatin
- Pomalidomide
- Ponatinib
- Posaconazole
- Pravastatin
- Prazosin
- Prednisone
- Probenecid
- Progesterone
- Promethazine
- Propafenone
- Propranolol
- Quetiapine
- Quinacrine
- Quinidine
- Quinine
- Ranitidine
- Regorafenib
- Reserpine
- Rilpivirine
- Risperidone
- Rivaroxaban
- Romidepsin
- Roxithromycin
- Salicylic Acid
- Saquinavir
- Selexipag
- Sertraline
- Silodosin
- Simeprevir
- Sirolimus
- Sofosbuvir
- Sorafenib
- Sparfloxacin
- Spironolactone
- Streptozocin
- Sumatriptan
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telaprevir
- Temsirolimus
- Terazosin
- Testosterone
- Ticagrelor
- Timolol
- Tolvaptan
- Toremifene
- Trazodone
- Trifluoperazine
- Triflupromazine
- Trimethoprim
- Trimipramine
- Troleandomycin
- Venlafaxine
- Verapamil
- Vinblastine
- Vincristine
- Voacamine
- Zidovudine
- Metoprolol
- Lansoprazole
- Acebutolol
- Ado-Trastuzumab Emtansine
- Amiodarone
- Arsenic Trioxide
- Azithromycin
- Bromocriptine
- Carbamazepine
- Chlorpromazine
- Citalopram
- Clopidogrel
- Cyclophosphamide
- Desipramine
- Diethylstilbestrol
- Doxazosin
- Eletriptan
- Erythromycin
- Ezetimibe
- Fluoxetine
- Gemcitabine
- Imipramine
- Itraconazole
- Lamivudine
- Lapatinib
- Lovastatin
- Megestrol Acetate
- Midazolam
- Mycophenolate Mofetil
- Nicardipine
- Nitrendipine
- Panobinostat
- Pimozide
- Prednisolone
- Protriptyline
- Reboxetine
- Ritonavir
- Selegiline
- Simvastatin
- Sulfinpyrazone
- Telmisartan
- Topotecan
- Ulipristal
- Vinorelbine
- Lisinopril