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  3. ABCA6

ABCA6 (ATP binding cassette subfamily A member 6)

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The Function of ABCA6

Probable transporter which may play a role in macrophage lipid homeostasis.

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Protein names

Recommended name:

ATP-binding cassette sub-family A member 6

ABCA6 SNPs

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  1. RS12453914 (ABCA6) ??
  2. RS77542162 (ABCA6) ??
  3. RS997781 (ABCA6) ??

Top Gene-Substance Interactions

ABCA6 Interacts with These Diseases

Disease Score

Substances That Increase ABCA6

Substances Interaction Organism Category

Substances That Decrease ABCA6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • GR
  • GR-alpha
  • MEF-2A
  • Zic1
  • FOXO1a
  • FOXO1

Tissue specificity:

Widely expressed with higher expression in liver.

Gene Pathways:

  • Transmembrane transport of small molecules
  • ABC transporters

Induction:

Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.

Developmental stage:

Expressed in fetal kidney, lung and liver.

Molecular Function:

  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atp Binding

Biological Processes:

  • Lipid Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ABC transporter ABCA6| ATP-binding cassette A6| ATP-binding cassette, sub-family A (ABC1), member 6| ATP-binding cassette, subfamily A (ABC1), member 6| ATP-binding cassette sub-family A member 6| ATP-binding cassette, sub-family A, member 6| ATP-binding cassette transporter sub-family A member 6| D623_10030304| EST155051| GW7_09584| H920_12284| PAL_GLEAN10014817| PANDA_015208| abca6

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