The Function of ABCA6
Probable transporter which may play a role in macrophage lipid homeostasis.
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Protein names
Recommended name:
ATP-binding cassette sub-family A member 6- RS12453914 (ABCA6) ??
- RS77542162 (ABCA6) ??
- RS997781 (ABCA6) ??
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Top Gene-Substance Interactions
ABCA6 Interacts with These Diseases
| Disease | Score |
Substances That Increase ABCA6
| Substances | Interaction | Organism | Category |
Substances That Decrease ABCA6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with higher expression in liver.
Gene Pathways:
Induction:
Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.
Developmental stage:
Expressed in fetal kidney, lung and liver.