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  3. ABAT

ABAT (4-aminobutyrate aminotransferase)

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The Function of ABAT

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

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Protein names

Recommended name:

4-aminobutyrate aminotransferase, mitochondrial

Short name:

(S

Alternative name(s):

GABA aminotransferase
GABA-AT
Gamma-amino-N-butyrate transaminase
GABA transaminase
GABA-T
L-AIBAT

ABAT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1299926 (ABAT) ??
  2. RS1731017 (ABAT) ??

Top Gene-Substance Interactions

ABAT Interacts with These Diseases

Disease Score

Substances That Increase ABAT

Substances Interaction Organism Category

Substances That Decrease ABAT

Substances Interaction Organism Category

Advanced Summary

ABAT is a gene which encodes the GABA transaminase enzyme. GABA transaminase catalyses the conversion of GABA into glutamate . Polymorphs in this gene influence the ratio of glutamate to GABA in the brain.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • RORalpha2
  • MEF-2A
  • Nkx2-2
  • GATA-1
  • Olf-1
  • YY1

Tissue specificity:

Liver > pancreas > brain > kidney > heart > placenta.

Gene Pathways:

  • Metabolic pathways
  • Butanoate metabolism
  • Valine, leucine and isoleucine degradation
  • Alanine, aspartate and glutamate metabolism
  • Neuronal System
  • Propanoate metabolism
  • beta-Alanine metabolism

Cofactor:

Binds 1 [2Fe-2S] cluster per homodimer.

Molecular Function:

  • (S)-3-Amino-2-Methylpropionate Transaminase Activity
  • 4-Aminobutyrate Transaminase Activity
  • Iron-Sulfur Cluster Binding
  • Metal Ion Binding
  • Protein Homodimerization Activity
  • Pyridoxal Phosphate Binding
  • Succinate-Semialdehyde Dehydrogenase Binding

Biological Processes:

  • Aging
  • Behavioral Response To Cocaine
  • Cerebellum Development
  • Copulation
  • Exploration Behavior
  • Gamma-Aminobutyric Acid Biosynthetic Process
  • Gamma-Aminobutyric Acid Catabolic Process
  • Locomotory Behavior
  • Negative Regulation Of Blood Pressure
  • Negative Regulation Of Dopamine Secretion
  • Negative Regulation Of Gamma-Aminobutyric Acid Secretion
  • Negative Regulation Of Platelet Aggregation
  • Neurotransmitter Catabolic Process
  • Positive Regulation Of Aspartate Secretion
  • Positive Regulation Of Dopamine Metabolic Process
  • Positive Regulation Of Heat Generation
  • Positive Regulation Of Inhibitory Postsynaptic Potential
  • Positive Regulation Of Insulin Secretion
  • Positive Regulation Of Prolactin Secretion
  • Positive Regulation Of Uterine Smooth Muscle Contraction
  • Response To Ethanol
  • Response To Hypoxia
  • Response To Iron Ion
  • Response To Nicotine

Drug Bank:

  • L-Alanine
  • Pyruvic Acid
  • Valproic Acid
  • Vigabatrin
  • Phenelzine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 4-aminobutyrate aminotransferase, mitochondrial| 4-aminobutyrate transaminase| beta-AlaAT| beta-alanine oxoglutarate aminotransferase| CB1_001392027| D623_10027979| EGK_12483| ENSMUSG00000051226| fj82a01| GABA aminotransferase| Gabaat| GABA-AT| Gabat| GABA-T| GABA transaminase| GABA transferase| GABT| gamma-amino-N-butyrate transaminase| H920_13827| I54| I79_001777| Laibat| L-AIBAT| M959_02016| MDA_GLEAN10010526| mitochondrial 4-aminobutyrate aminotransferase| N300_08895| N302_11681| N305_02906| N307_08109| N308_08955| N310_01869| N311_07248| N312_12196| N321_11391| N322_11149| N324_07569| N326_04934| N327_11179| N328_03278| N329_09193| N330_11843| N331_08087| N333_01041| N334_11182| N335_14363| N336_11865| N339_11173| N340_04664| N341_04658| NPD009| PAL_GLEAN10011559| PANDA_008396| (S)-3-amino-2-methylpropionate transaminase| TREES_T100015557| UY3_01301| X61497| Y1Q_010495| abat

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