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  3. AADAC

AADAC (Arylacetamide deacetylase)

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The Function of AADAC

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.

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Protein names

Recommended name:

Arylacetamide deacetylase

Top Gene-Substance Interactions

Substances That Increase AADAC

Substances Interaction Organism Category

Substances That Decrease AADAC

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO4
  • C/EBPalpha
  • MEF-2A
  • TBP

Tissue specificity:

Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.

Induction:

Down-regulated following infection with hepatis C virus which results in impaired triacylglycerol lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to infection that is aimed at limiting viral production.

Molecular Function:

  • Catalytic Activity
  • Deacetylase Activity
  • Lipase Activity
  • Serine Hydrolase Activity
  • Triglyceride Lipase Activity

Biological Processes:

  • Positive Regulation Of Triglyceride Catabolic Process
  • Xenobiotic Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Aada| AADACL2| arylacetamide deacetylase (esterase)| arylacetamide deacetylase-like 2| arylacetamide deacetylase-like protein| AS27_08432| AS28_05792| CES5A1| D623_10024441| DAC| I79_020256| MDA_GLEAN10008698| N301_00511| N302_12494| N303_11010| N306_10243| N307_03267| N312_12696| N321_10608| N322_11014| N326_08439| N327_11770| N329_11932| N330_01786| N331_07245| N332_12400| N333_01190| N335_00114| N340_05459| PAL_GLEAN10018485| PANDA_004462| UY3_04739| Y1Q_013840| zmp:0000000710| aadac

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