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  3. UGT1A6

UGT1A6 (UDP glucuronosyltransferase family 1 member A6)

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Summary of UGT1A6

This gene encodes a UDP-glucuronosyltransferase. It transforms small molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble metabolites that can be excreted (R). 

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The Function of UGT1A6

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1.

Protein names

Recommended name:

UDP-glucuronosyltransferase 1-6

Short name:

UGT1F

Alternative name(s):

UDPGT 1-6
UGT1*6
UGT1-06
UGT1.6
Phenol-metabolizing UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1-F
UGT-1F
UDP-glucuronosyltransferase 1A6

UGT1A6 SNPs

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  1. RS1105879 (UGT1A6) ??
  2. RS11563251 (UGT1A6) ??
  3. RS11891311 (UGT1A6) ??
  4. RS17863783 (UGT1A6) ??
  5. RS17863787 (UGT1A6) ??
  6. RS1875263 (UGT1A6) ??
  7. RS2070959 (UGT1A6) ??
  8. RS3755319 (UGT1A6) ??
  9. RS4148323 (UGT1A6) ??
  10. RS4148324 (UGT1A6) ??
  11. RS4148325 (UGT1A6) ??
  12. RS4477910 (UGT1A6) ??
  13. RS4663969 (UGT1A6) ??
  14. RS6742078 (UGT1A6) ??
  15. RS6759892 (UGT1A6) ??
  16. RS887829 (UGT1A6) ??
  17. RS929596 (UGT1A6) ??

Top Gene-Substance Interactions

Substances That Increase UGT1A6

Substances Interaction Organism Category

Substances That Decrease UGT1A6

Substances Interaction Organism Category

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • AP-1
  • c-Jun
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Metabolism of xenobiotics by cytochrome P450
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Ascorbate and aldarate metabolism
  • Drug metabolism - other enzymes
  • Other types of O-glycan biosynthesis
  • Pentose and glucuronate interconversions
  • Porphyrin and chlorophyll metabolism
  • Starch and sucrose metabolism

Molecular Function:

  • Enzyme Binding
  • Glucuronosyltransferase Activity
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Cellular Glucuronidation
  • Flavonoid Biosynthetic Process
  • Flavonoid Glucuronidation
  • Negative Regulation Of Cellular Glucuronidation
  • Negative Regulation Of Fatty Acid Metabolic Process
  • Negative Regulation Of Glucuronosyltransferase Activity
  • Xenobiotic Glucuronidation
  • Xenobiotic Metabolic Process

Drug Bank:

  • Acetaminophen
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Propofol
  • Valproic Acid
  • Deferiprone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A1| UDP-glucuronosyltransferase| UDP-glucuronosyltransferase 1-6| GNT1| UDP-glucuronosyltransferase 1A1| UDP glucuronosyltransferase 1 family, polypeptide A1| UDP glucuronosyltransferase 1 family, polypeptide A6| UDP glycosyltransferase 1 family, polypeptide A6| UDPGT| Ugt1| UGT1A1| HLUGP| HLUGP1| phenol-metabolizing UDP-glucuronosyltransferase| P-nitrophenol specific| P-nitrophenol-specific UDPGT| UDP glucuronosyltransferase 1A6| UDP-glucuronosyltransferase 1A6| UDP-glucuronosyltransferase 1-F| UDP-glucuronosyltransferase 1 family polypeptide A6s| UDP glycosyl transferase 1A6| UDPGT 1-6| UGT1-06| UGT1.6| UGT1*6| UGT1A6S| Ugt1a7| UGT1F| UGT-1F| ugt1a6

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