Summary of UGT1A6
This gene encodes a UDP-glucuronosyltransferase. It transforms small molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble metabolites that can be excreted (R).
The Function of UGT1A6
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1.
Protein names
Recommended name:
UDP-glucuronosyltransferase 1-6Short name:
UGT1FAlternative name(s):
UDPGT 1-6UGT1*6
UGT1-06
UGT1.6
Phenol-metabolizing UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1-F
UGT-1F
UDP-glucuronosyltransferase 1A6
- RS1105879 (UGT1A6) ??
- RS11563251 (UGT1A6) ??
- RS11891311 (UGT1A6) ??
- RS17863783 (UGT1A6) ??
- RS17863787 (UGT1A6) ??
- RS1875263 (UGT1A6) ??
- RS2070959 (UGT1A6) ??
- RS3755319 (UGT1A6) ??
- RS4148323 (UGT1A6) ??
- RS4148324 (UGT1A6) ??
- RS4148325 (UGT1A6) ??
- RS4477910 (UGT1A6) ??
- RS4663969 (UGT1A6) ??
- RS6742078 (UGT1A6) ??
- RS6759892 (UGT1A6) ??
- RS887829 (UGT1A6) ??
- RS929596 (UGT1A6) ??
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Top Gene-Substance Interactions
Substances That Increase UGT1A6
| Substances | Interaction | Organism | Category |
Substances That Decrease UGT1A6
| Substances | Interaction | Organism | Category |
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine.
Gene Pathways:
- Metabolic pathways
- Metabolism
- Steroid hormone biosynthesis
- Metabolism of xenobiotics by cytochrome P450
- Retinol metabolism
- Drug metabolism - cytochrome P450
- Ascorbate and aldarate metabolism
- Drug metabolism - other enzymes
- Other types of O-glycan biosynthesis
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Starch and sucrose metabolism
Molecular Function:
- Enzyme Binding
- Glucuronosyltransferase Activity
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
Biological Processes:
- Cellular Glucuronidation
- Flavonoid Biosynthetic Process
- Flavonoid Glucuronidation
- Negative Regulation Of Cellular Glucuronidation
- Negative Regulation Of Fatty Acid Metabolic Process
- Negative Regulation Of Glucuronosyltransferase Activity
- Xenobiotic Glucuronidation
- Xenobiotic Metabolic Process