Summary of UGT1A1
The UGT1A1 gene encodes enzymes called UDP-glucuronosyltransferases. They perform glucuronidation, which is when glucuronic acid is attached to a different substance. Mutations are associated with warfarin resistance and jaundice in newborns (R).
The Function of UGT1A1
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Protein names
Recommended name:
UDP-glucuronosyltransferase 1-1Short name:
UGT1AAlternative name(s):
UDPGT 1-1UGT1*1
UGT1-01
UGT1.1
Bilirubin-specific UDPGT isozyme 1
hUG-BR1
UDP-glucuronosyltransferase 1-A
UGT-1A
UDP-glucuronosyltransferase 1A1
- RS11563251 (UGT1A1) ??
- RS34815109 (UGT1A1) ??
- RS34983651 (UGT1A1) ??
- RS35600288 (UGT1A1) ??
- RS3755319 (UGT1A1) ??
- RS4148323 (UGT1A1) ??
- RS4148324 (UGT1A1) ??
- RS4148325 (UGT1A1) ??
- RS6742078 (UGT1A1) ??
- RS887829 (UGT1A1) ??
- RS929596 (UGT1A1) ??
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Top Gene-Substance Interactions
UGT1A1 Interacts with These Diseases
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Substances That Increase UGT1A1
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Substances That Decrease UGT1A1
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Advanced Summary
Crigler-Najjar syndrome At least 85 mutations in the UGT1A1 gene that cause Crigler-Najjar syndrome have been identified. This condition occurs when both copies of the UGT1A1 gene in each cell are altered. Crigler-Najjar syndrome is characterized by high levels of unconjugated bilirubin in the blood (unconjugated hyperbilirubinemia) and yellowing of the skin and eyes (jaundice). Some affected individuals develop a form of brain damage called kernicterus due to the accumulation of unconjugated bilirubin in the brain, which can be lethal. Mutations in the UGT1A1 gene that cause Crigler-Najjar syndrome result in reduced or absent function of the bilirubin-UGT enzyme. People with Crigler-Najjar syndrome type 1 (CN1) have no enzyme function, while people with Crigler-Najjar syndrome type 2 (CN2) have less than 20 percent of normal function. The signs and symptoms of CN1 are more severe than those of CN2. The loss of bilirubin-UGT function decreases glucuronidation of unconjugated bilirubin. This toxic substance then builds up in the body, causing hyperbilirubinemia, jaundice, and sometimes, kernicterus. Gilbert syndrome Changes in the UGT1A1 gene can cause Gilbert syndrome. This condition is characterized by periods of mild unconjugated hyperbilirubinemia, which rarely leads to episodes of jaundice. Gilbert syndrome occurs worldwide, but some mutations are seen more often in particular populations. In many populations, the most common genetic change that causes Gilbert syndrome occurs in an area near the UGT1A1 gene called the promoter region, which controls the production of the bilirubin-UGT enzyme. This change must occur in both copies of the UGT1A1 gene to cause Gilbert syndrome. The common genetic change involved in Gilbert syndrome, called UGT1A1*28, results from the addition of two DNA building blocks (nucleotides) to an important sequence in the promoter region known as the TATA box. The normal UGT1A1 TATA box sequence is written as A(TA)6TAA. The UGT1A1*28 sequence includes an extra TA nucleotide pair and is written as A(TA)7TAA. This genetic change creates a longer than normal TATA box and impairs protein production. The UGT1A1*28 change, however, is uncommon in Asian populations. Asians with Gilbert syndrome often have a mutation in one copy of the UGT1A1 gene that results in the change of a single protein building block (amino acid) in the bilirubin-UGT enzyme. The most common mutation in this population replaces the amino acid glycine with the amino acid arginine at position 71 of the enzyme (written as Gly71Arg or G71R). This type of mutation, known as a missense mutation, results in reduced enzyme function. People with Gilbert syndrome have approximately 30 percent of normal bilirubin-UGT enzyme function. As a result, unconjugated bilirubin is not glucuronidated quickly enough, and it builds up in the body, causing mild hyperbilirubinemia. warfarin resistance Genetics Home Reference provides information about warfarin resistance. other disorders Although jaundice is common in newborns, mutations in the UGT1A1 gene increase the risk of developing a more severe condition called transient familial neonatal hyperbilirubinemia. In this condition, severe unconjugated hyperbilirubinemia and jaundice occur in newborns and usually disappear in 1 to 2 weeks. Some babies develop kernicterus (which can be lethal), hearing loss, or other neurological problems. The G71R mutation is the most common mutation associated with transient familial neonatal hyperbilirubinemia. Asian but not white newborns with a UGT1A1 gene mutation seem to be at risk of developing this condition. Sometimes newborn jaundice is associated with breastfeeding: Unconjugated bilirubin levels increase when the baby is breastfed, causing jaundice, and return to normal when breastfeeding is stopped for a prolonged period. This condition, often called breast milk jaundice, appears 5 or 10 days after birth and disappears at around 4 months of age. Kernicterus is not typically seen in infants with breast milk jaundice. Research suggests that a substance in the breast milk of mothers of affected infants blocks glucuronidation. In addition, many affected infants have a mutation in one copy of the UGT1A1 gene, most commonly the G71R mutation, and the mutation is thought to underlie the unconjugated hyperbilirubinemia. The substance in the breast milk may trigger the buildup of unconjugated bilirubin in infants with already impaired bilirubin-UGT enzyme function.
The UGT1A1 gene belongs to a family of genes that provide instructions for making enzymes called UDP-glucuronosyltransferases. These enzymes perform a chemical reaction called glucuronidation, in which a compound called glucuronic acid is attached (conjugated) to one of a number of different substances. The protein produced from the UGT1A1 gene, called the bilirubin uridine diphosphate glucuronosyl transferase (bilirubin-UGT) enzyme, is the only enzyme that glucuronidates bilirubin, a substance produced when red blood cells are broken down. This enzyme converts the toxic form of bilirubin (unconjugated bilirubin) to its nontoxic form (conjugated bilirubin), making it able to be dissolved and removed from the body. The bilirubin-UGT enzyme is primarily found in cells of the liver, where bilirubin glucuronidation takes place. Conjugated bilirubin is dissolved in bile, a fluid produced in the liver, and excreted with solid waste.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin.
Gene Pathways:
- Metabolic pathways
- Metabolism
- Steroid hormone biosynthesis
- Metabolism of xenobiotics by cytochrome P450
- Retinol metabolism
- Drug metabolism - cytochrome P450
- Ascorbate and aldarate metabolism
- Drug metabolism - other enzymes
- Other types of O-glycan biosynthesis
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Starch and sucrose metabolism
Molecular Function:
- Enzyme Binding
- Enzyme Inhibitor Activity
- Glucuronosyltransferase Activity
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
- Retinoic Acid Binding
- Steroid Binding
Biological Processes:
- Acute-Phase Response
- Animal Organ Regeneration
- Bilirubin Conjugation
- Biphenyl Catabolic Process
- Cellular Glucuronidation
- Cellular Response To Estradiol Stimulus
- Cellular Response To Ethanol
- Cellular Response To Glucocorticoid Stimulus
- Digestion
- Drug Metabolic Process
- Estrogen Metabolic Process
- Flavone Metabolic Process
- Flavonoid Biosynthetic Process
- Flavonoid Glucuronidation
- Heme Catabolic Process
- Heterocycle Metabolic Process
- Liver Development
- Negative Regulation Of Cellular Glucuronidation
- Negative Regulation Of Fatty Acid Metabolic Process
- Negative Regulation Of Glucuronosyltransferase Activity
- Negative Regulation Of Steroid Metabolic Process
- Response To Lipopolysaccharide
- Response To Nutrient
- Response To Starvation
- Retinoic Acid Metabolic Process
- Steroid Metabolic Process
- Xenobiotic Glucuronidation
Drug Bank:
- Erlotinib
- Nilotinib
- Raltegravir
- Rifampicin
- Acetaminophen
- Adenine
- Atorvastatin
- Axitinib
- Diclofenac
- Dolutegravir
- Eltrombopag
- Etoposide
- Ezetimibe
- Ezogabine
- Flunitrazepam
- Flurbiprofen
- Ibuprofen
- Indacaterol
- Indomethacin
- Irinotecan
- Losartan
- Morphine
- Mycophenolate Mofetil
- Mycophenolic Acid
- Naltrexone
- Naproxen
- Propofol
- Regorafenib
- Simvastatin
- Sorafenib
- Testosterone Propionate
- Abacavir
- Estradiol
- Fluvastatin
- Lovastatin
- Pazopanib
- Suprofen