Summary of TUSC3
The TUSC3 gene codes for a protein called tumor suppressor candidate 3.
Despite what its name might sound like, the main function of the TUSC3 protein is actually to regulate the metabolism, uptake, and transport of magnesium throughout the body’s cells [R, R, R].
Magnesium is an essential dietary nutrient that is important for many different processes in the body and brain, including hormone signaling [R, R], DNA replication [R], producing energy for cells [R, R], and neuronal communication [R, R, R, R], to name just a few.
SNPs in this gene -- such as rs240657 -- have been associated with cognitive function [R].
To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on TUSC3!
>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.
The Function of TUSC3
Magnesium transporter (PubMed:19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed:24685145).
Protein names
Recommended name:
Tumor suppressor candidate 3Alternative name(s):
Magnesium uptake/transporter TUSC3Protein N33
- RS12676170 (TUSC3) ??
- RS2172820 (TUSC3) ??
- RS240657 (TUSC3) ??
- RS4831760 (TUSC3) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
TUSC3 Interacts with These Diseases
| Disease | Score |
Substances That Increase TUSC3
| Substances | Interaction | Organism | Category |
Substances That Decrease TUSC3
| Substances | Interaction | Organism | Category |
Advanced Summary
The TUSC3 gene codes for a protein called tumor suppressor candidate 3.
Despite what its name might sound like, the main function of the TUSC3 protein is actually to regulate the metabolism, uptake, and transport of magnesium throughout the body’s cells [R, R, R].
Magnesium is an essential dietary nutrient that is important for many different processes in the body and brain, including hormone signaling [R, R], DNA replication [R], producing energy for cells [R, R], and neuronal communication [R, R, R, R], to name just a few.
SNPs in this gene -- such as rs240657 -- have been associated with cognitive function [R].
To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on TUSC3!
>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.
Gene Pathways:
Molecular Function:
Biological Processes:
- Protein N-Linked Glycosylation
- Magnesium Ion Transport
- Protein N-Linked Glycosylation Via Asparagine
- Cognition
- Transmembrane Transport