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TUSC3 (Tumor suppressor candidate 3)

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Summary of TUSC3

The TUSC3 gene codes for a protein called tumor suppressor candidate 3.

Despite what its name might sound like, the main function of the TUSC3 protein is actually to regulate the metabolism, uptake, and transport of magnesium throughout the body’s cells [R, R, R].

Magnesium is an essential dietary nutrient that is important for many different processes in the body and brain, including hormone signaling [R, R], DNA replication [R], producing energy for cells [R, R], and neuronal communication [R, R, R, R], to name just a few.

SNPs in this gene -- such as rs240657 -- have been associated with cognitive function [R].

 

To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on TUSC3!

 


>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.


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The Function of TUSC3

Magnesium transporter (PubMed:19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed:24685145).

Protein names

Recommended name:

Tumor suppressor candidate 3

Alternative name(s):

Magnesium uptake/transporter TUSC3
Protein N33

TUSC3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12676170 (TUSC3) ??
  2. RS2172820 (TUSC3) ??
  3. RS240657 (TUSC3) ??
  4. RS4831760 (TUSC3) ??

Top Gene-Substance Interactions

TUSC3 Interacts with These Diseases

Disease Score

Substances That Increase TUSC3

Substances Interaction Organism Category

Substances That Decrease TUSC3

Substances Interaction Organism Category

Advanced Summary

The TUSC3 gene codes for a protein called tumor suppressor candidate 3.

Despite what its name might sound like, the main function of the TUSC3 protein is actually to regulate the metabolism, uptake, and transport of magnesium throughout the body’s cells [R, R, R].

Magnesium is an essential dietary nutrient that is important for many different processes in the body and brain, including hormone signaling [R, R], DNA replication [R], producing energy for cells [R, R], and neuronal communication [R, R, R, R], to name just a few.

SNPs in this gene -- such as rs240657 -- have been associated with cognitive function [R].

 

To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on TUSC3!

 


>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.


 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.

Gene Pathways:

  • Metabolic pathways
  • Metabolism of proteins
  • N-Glycan biosynthesis
  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Magnesium Ion Transmembrane Transporter Activity

Biological Processes:

  • Cognition
  • Magnesium Ion Transport
  • Protein N-Linked Glycosylation
  • Protein N-Linked Glycosylation Via Asparagine
  • Transmembrane Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08910| AS27_13331| AS28_04919| D623_10033362| D8S1992| GW7_11864| H920_04259| I79_017070| m33| M91_08856| M959_12704| magnesium uptake/transporter TUSC3| MDA_GLEAN10019650| MRT22| mrt7| N300_04146| N301_01941| N302_04123| N303_02697| N305_04053| N306_00529| N307_12148| N308_01503| N310_00809| N312_11600| N326_12368| N327_12858| N328_11687| N33| N332_04870| N333_11629| N336_02517| N341_11299| oligosaccharyltransferase 3 homolog A| ost3a| PAL_GLEAN10021696| PANDA_020782| Putative prostate cancer tumor suppressor| putative tumor suppressor candidate 3| tumor suppressor candidate 3-like protein| unm_sa1726| Y1Q_030588| Y956_08149| Z169_11251| tusc3

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