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  3. SULT2A1

SULT2A1 (Sulfotransferase family 2A member 1)

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The Function of SULT2A1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

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Protein names

Recommended name:

Bile salt sulfotransferase

Short name:

HST

Alternative name(s):

Dehydroepiandrosterone sulfotransferase
DHEA-ST
Hydroxysteroid Sulfotransferase
ST2
ST2A3
Sulfotransferase 2A1
ST2A1

SULT2A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS182420 (SULT2A1) ??
  2. RS2547231 (SULT2A1) ??

Top Gene-Substance Interactions

SULT2A1 Interacts with These Diseases

Disease Score

Substances That Increase SULT2A1

Substances Interaction Organism Category

Substances That Decrease SULT2A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • AhR
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Gene Pathways:

  • Metabolism
  • Steroid hormone biosynthesis
  • Bile secretion
  • Sulfur metabolism

Molecular Function:

  • Aryl Sulfotransferase Activity
  • Bile-Salt Sulfotransferase Activity
  • Estrone Sulfotransferase Activity
  • Steroid Sulfotransferase Activity
  • Sulfotransferase Activity

Biological Processes:

  • 3'-Phosphoadenosine 5'-Phosphosulfate Metabolic Process
  • Bile Acid Catabolic Process
  • Digestion
  • Steroid Metabolic Process
  • Sulfation

Drug Bank:

  • Acetaminophen
  • Abiraterone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| HST| St2| alcohol/hydroxysteroid sulfotransferase| alcohol sulfotransferase| AST-RB2| bile-salt sulfotranasferase 2A1| bile salt sulfotransferase| bile salt sulfotransferase 1| bile-salt sulfotransferase 2A1| CB1_000516001| cytosolic sulfotransferase family 2A dehydroepiandrosterone (DHEA)-preferring member 1| D623_10017572| DHEAS| dhea-st| EGK_10823| hSTa| Hydroxysteroid sulfotransferase| hydroxysteroid sulfotransferase a| hydroxysteroid sulfotransferase subunit| MDA_GLEAN10005914| mSTa1| PAL_GLEAN10004619| Smp-2| ST| ST-20| st2a1| st2a3| sta| STD| Sth1| Sth2| Sulfotransferase 2A1| sulfotransferase, DHEA preferring| sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1| sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1| sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1| sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone-preferring, member 1| sulfotransferase hydroxysteroid gene 2| sulfotransferase, hydroxysteroid preferring 1| sulfotransferase, hydroxysteroid preferring 2| sult2a1

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