The Function of SULT2A1
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
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Protein names
Recommended name:
Bile salt sulfotransferaseShort name:
HSTAlternative name(s):
Dehydroepiandrosterone sulfotransferaseDHEA-ST
Hydroxysteroid Sulfotransferase
ST2
ST2A3
Sulfotransferase 2A1
ST2A1
- RS182420 (SULT2A1) ??
- RS2547231 (SULT2A1) ??
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Top Gene-Substance Interactions
SULT2A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SULT2A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SULT2A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.
Gene Pathways:
Molecular Function:
- Aryl Sulfotransferase Activity
- Bile-Salt Sulfotransferase Activity
- Estrone Sulfotransferase Activity
- Steroid Sulfotransferase Activity
- Sulfotransferase Activity
Biological Processes:
- 3'-Phosphoadenosine 5'-Phosphosulfate Metabolic Process
- Bile Acid Catabolic Process
- Digestion
- Steroid Metabolic Process
- Sulfation