The Function of SLC2A4
Insulin-regulated facilitative glucose transporter.
Protein names
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4Short name:
GLUT-4Alternative name(s):
Glucose transporter type 4, insulin-responsive- RS5415 (SLC2A4) ??
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Top Gene-Substance Interactions
SLC2A4 Interacts with These Diseases
Disease | Score |
Substances That Increase SLC2A4
Substances | Interaction | Organism | Category |
Substances That Decrease SLC2A4
Substances | Interaction | Organism | Category |
Advanced Summary
From UniProt: Diabetes mellitus, non-insulin-dependent (NIDDM): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin . Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [MIM:125853]
From NCBI Gene: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008] From UniProt: Insulin-regulated facilitative glucose transporter.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Skeletal and cardiac muscles; brown and white fat.
Gene Pathways:
Molecular Function:
Biological Processes:
- Amylopectin Biosynthetic Process
- Brown Fat Cell Differentiation
- Carbohydrate Metabolic Process
- Cellular Response To Hypoxia
- Cellular Response To Insulin Stimulus
- Cellular Response To Osmotic Stress
- Cellular Response To Tumor Necrosis Factor
- Glucose Homeostasis
- Glucose Import
- Glucose Transport
- Response To Ethanol