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  3. SLC2A4

SLC2A4 (Solute carrier family 2 member 4)

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The Function of SLC2A4

Insulin-regulated facilitative glucose transporter.

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Protein names

Recommended name:

Solute carrier family 2, facilitated glucose transporter member 4

Short name:

GLUT-4

Alternative name(s):

Glucose transporter type 4, insulin-responsive

SLC2A4 SNPs

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  1. RS5415 (SLC2A4) ??

Top Gene-Substance Interactions

SLC2A4 Interacts with These Diseases

Disease Score

Substances That Increase SLC2A4

Substances Interaction Organism Category

Substances That Decrease SLC2A4

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Diabetes mellitus, non-insulin-dependent (NIDDM): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin . Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [MIM:125853]

     From NCBI Gene: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008] From UniProt: Insulin-regulated facilitative glucose transporter.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • C/EBPalpha
  • MEF-2A
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Skeletal and cardiac muscles; brown and white fat.

Gene Pathways:

  • Metabolism
  • Disease
  • Adipocytokine signaling pathway
  • Insulin signaling pathway
  • Membrane Trafficking
  • Transmembrane transport of small molecules
  • Translocation of Glut4 to the Plasma Membrane
  • Type II diabetes mellitus

Molecular Function:

  • D-Glucose Transmembrane Transporter Activity
  • Glucose Transmembrane Transporter Activity

Biological Processes:

  • Amylopectin Biosynthetic Process
  • Brown Fat Cell Differentiation
  • Carbohydrate Metabolic Process
  • Cellular Response To Hypoxia
  • Cellular Response To Insulin Stimulus
  • Cellular Response To Osmotic Stress
  • Cellular Response To Tumor Necrosis Factor
  • Glucose Homeostasis
  • Glucose Import
  • Glucose Transport
  • Response To Ethanol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

solute carrier family 2 (facilitated glucose transporter), membe| CB1_000230013| D623_10021024| EGK_08113| EH28_05524| glucose transport 4| glucose transporter 4| Glucose transporter 4, insuline-responsive| glucose transporter type 4| glucose transporter type 4, insulin-responsive| glucose transporter type four| Glut4| GLUT-4| GT2| H920_19721| I79_002770| insulin responsive glucose transporter| insulin-responsive glucose transporter| insulin-responsive glucose transporter type 4| M91_13053| MDA_GLEAN10018283| PAL_GLEAN10010166| Solute carrier family 2, facilitated glucose transporter member 1| solute carrier family 2 (facilitated glucose transporter), member 4| solute carrier family 2, facilitated glucose transporter member 4| solute carrier family 2 , member 4| TREES_T100004070| UY3_02613| slc2a4

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