Summary of P2RY2
Uridine and adensoine nucleotides activate this receptor. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation.
P2Y2 nucleotide receptor (P2Y2R) is activated with equal potency by adenosine triphosphate (ATP) and uridine 5'-triphosphate (UTP) (R).
Uridine activates the P2Y2 receptor, which helps with neurite outgrowth (R). This receptor potentiates the effects of neurotrophins (such as NGF ) in neuronal development and regeneration.
P2Y2 receptors are required for enhanced neuronal differentiation and increase growth-associated protein-43 (GAP-43), a marker for axonal growth (R).
The P2Y2 receptor is believed to play an important role in neuroprotection under inflammatory conditions. The receptors are increased under inflammatory conditions ( IL-1b ) for this reason (R, R2).
The Function of P2RY2
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Protein names
Recommended name:
P2Y purinoceptor 2Short name:
P2Y2Alternative name(s):
ATP receptorP2U purinoceptor 1
P2U1
P2U receptor 1
Purinergic receptor
- RS10898909 (P2RY2) ??
- RS1783596 (P2RY2) ??
- RS1791933 (P2RY2) ??
- RS4382936 (P2RY2) ??
- RS4944831 (P2RY2) ??
- RS4944832 (P2RY2) ??
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Top Gene-Substance Interactions
Fixes
Uridine if the receptor isn't working well.
Substances That Increase P2RY2
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Substances That Decrease P2RY2
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Advanced Summary
Uridine /Adenosine causes vasodilation through eNOS in blood vessel cell lines in response to blood flow (via P2Y2 receptor). Mice with P2Y2 deficiency lacked flow-induced vasodilation and developed hypertension that was accompanied by reduced eNOS activation (R).
The P2Y2 receptor on osteoblasts strongly inhibits bone mineralization and formation (via P2Y2) (R, R, R).
P2RY2 enhances proliferation, adhesion, migration of cancer and increases immunosuppressive ability of Tregs (bad for cancer, good for autoimmune conditions).
P2RY2 can induce IL-6 and IL-8 secretion.
P2RY2 gene associated with essential hypertension in Japanese men.
P2RY2 gene is associated with cerebral infarction in Japanese subjects.
Selective loss of P2Y2 nucleotide receptor is associated with Alzheimer's disease neuropathology.
Nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Spleen, testis, kidney, liver, lung, heart and brain.
Molecular Function:
Biological Processes:
- Cellular Ion Homeostasis
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Mucus Secretion
- Regulation Of Vasodilation
- Aging
- Cellular Response To Interleukin-1
- Cellular Response To Lipopolysaccharide
- Cellular Response To Purine-Containing Compound
- In Utero Embryonic Development
- Negative Regulation Of Ossification
- Positive Regulation Of Chemokine Production
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Neuron Projection Development
- Positive Regulation Of Penile Erection
- Positive Regulation Of Prostaglandin Secretion
- Positive Regulation Of Smooth Muscle Cell Migration
- Response To Growth Factor
- Sensory Perception Of Pain
- Wound Healing