Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

IRS-1 plays important biological function for both metabolic and growth promoting pathways: mice deficient of IRS1 have only a mild diabetic phenotype, but a pronounced growth impairment.  Mice without IRS1 only reach 50% of the weight of normal mice.

IRS-1 may also play a role in cancer, as it has been shown that mice with overproduction of IRS-1 develop breast cancer . (Ref) Lower levels of IRS1 cause insulin resistance. IRS1 is needed for cells to take up insulin . (Ref)

     From NCBI Gene: Diabetes mellitus type 2From UniProt: Diabetes mellitus, non-insulin-dependent (NIDDM): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin . Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [MIM:125853]

     From NCBI Gene: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] From UniProt: May mediate the control of various cellular processes by insulin . When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• ER-alpha
• GR-beta
• AP-1
• c-Jun
• FOXO1a
• FOXO1
• USF1
• USF-1

Molecular Function:

• 1-Phosphatidylinositol-3-Kinase Activity
• Insulin-Like Growth Factor Receptor Binding
• Insulin Receptor Binding
• Phosphatidylinositol 3-Kinase Binding
• Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
• Protein Kinase C Binding
• Ras Guanyl-Nucleotide Exchange Factor Activity
• Sh2 Domain Binding
• Signal Transducer Activity
• Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity

Biological Processes:

• Cellular Response To Insulin Stimulus
• Glucose Homeostasis
• Insulin-Like Growth Factor Receptor Signaling Pathway
• Insulin Receptor Signaling Pathway
• Mapk Cascade
• Negative Regulation Of Insulin Receptor Signaling Pathway
• Negative Regulation Of Insulin Secretion
• Phosphatidylinositol 3-Kinase Signaling
• Phosphatidylinositol-Mediated Signaling
• Positive Regulation Of Cell Proliferation
• Positive Regulation Of Fatty Acid Beta-Oxidation
• Positive Regulation Of Glucose Import
• Positive Regulation Of Glucose Import In Response To Insulin Stimulus
• Positive Regulation Of Glucose Metabolic Process
• Positive Regulation Of Glycogen Biosynthetic Process
• Positive Regulation Of Insulin Receptor Signaling Pathway
• Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
• Regulation Of Phosphatidylinositol 3-Kinase Signaling
• Response To Insulin
• Response To Peptide Hormone
• Signal Transduction
• Transcription, Dna-Templated

*synonyms