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  3. IL12A

IL12A (Interleukin 12A)

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Summary of IL12A

IL12A (interleukin 12A) encodes for a protein that acts on T and natural killer cells . It is required for the T-cell-independent induction of interferon (IFN)-gamma and is important for the differentiation of Th1 and Th2 cells (R).

Interleukin-12 is primarily a cytokine that is immune stimulatory and increases the Th1 immune system.

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The Function of IL12A

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Protein names

Recommended name:

Interleukin-12 subunit alpha

Short name:

NKSF1

Alternative name(s):

IL-12A
Cytotoxic lymphocyte maturation factor 35 kDa subunit
CLMF p35
IL-12 subunit p35
NK cell stimulatory factor chain 1

IL12A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2243123 (IL12A) ??
  2. RS6441286 (IL12A) ??

Top Gene-Substance Interactions

IL12A Interacts with These Diseases

Disease Score

Substances That Increase IL12A

Substances Interaction Organism Category

Substances That Decrease IL12A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • Measles
  • RIG-I-like receptor signaling pathway
  • Toll-like receptor signaling pathway
  • Tuberculosis
  • Chagas disease (American trypanosomiasis)
  • Toxoplasmosis
  • African trypanosomiasis
  • Allograft rejection
  • Amoebiasis
  • Leishmaniasis
  • Malaria
  • Type I diabetes mellitus

Induction:

Down-regulated in response to enterovirus 71 (EV71) infection.

Molecular Function:

  • Interleukin-12 Beta Subunit Binding
  • Interleukin-12 Receptor Binding
  • Interleukin-27 Binding
  • Protein Heterodimerization Activity

Biological Processes:

  • Cell Cycle Arrest
  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Virus
  • Defense Response To Gram-Positive Bacterium
  • Defense Response To Protozoan
  • Extrinsic Apoptotic Signaling Pathway
  • Immune Response
  • Negative Regulation Of Interleukin-17 Production
  • Negative Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Dendritic Cell Chemotaxis
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Lymphocyte Proliferation
  • Positive Regulation Of Mononuclear Cell Proliferation
  • Positive Regulation Of Natural Killer Cell Activation
  • Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
  • Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
  • Positive Regulation Of Nk T Cell Activation
  • Positive Regulation Of Smooth Muscle Cell Apoptotic Process
  • Positive Regulation Of T Cell Differentiation
  • Positive Regulation Of T Cell Mediated Cytotoxicity
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
  • Response To Lipopolysaccharide
  • Response To Uv-B
  • Response To Virus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

P35| CB1_001360005| CLMF| CLMF p35| cytotoxic lymphocyte maturation factor 1, p35| cytotoxic lymphocyte maturation factor 35 kDa subunit| H920_04920| IL12| IL-12A| il-12 alpha| Il-12 p35| IL12p35| IL-12p35| IL-12 p35 subunit| IL-12p35 subunit| IL-12 subunit p35| IL-12, subunit p35| IL35 subunit| interleukin 12| interleukin 12 35kDa subunit| interleukin 12 35kD subunit| interleukin-12 alpha| interleukin-12 alpha chain| interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)| interleukin 12a p35 subunit| interleukin 12B| interleukin-12 beta p35 subunit| interleukin 12, p35| interleukin-12p35| interleukin 12 p35 subunit| interleukin-12 p35 subunit| interleukin 12 polypeptide 35| Interleukin-12 subunit alpha| interleukin-12 subunit alpha-like protein| interleukin 12 subunit p35| Ll12a| M959_09101| MDA_GLEAN10017669| N301_00541| N302_12463| N303_12016| N306_04978| N307_10936| N310_12935| N311_08568| N320_07453| N322_00798| N325_04011| N327_09915| N330_07001| N331_07220| N334_05075| N335_07784| N336_00773| N339_05051| N340_01579| N341_03723| natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35| NF cell stimulatory factor chain 1| NFSK| NK cell stimulatory factor chain 1| NKSF1| PANDA_019813| TREES_T100015302| Y1Q_000477| il12a

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