Summary of IL12A
IL12A (interleukin 12A) encodes for a protein that acts on T and natural killer cells . It is required for the T-cell-independent induction of interferon (IFN)-gamma and is important for the differentiation of Th1 and Th2 cells (R).
Interleukin-12 is primarily a cytokine that is immune stimulatory and increases the Th1 immune system.
The Function of IL12A
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Protein names
Recommended name:
Interleukin-12 subunit alphaShort name:
NKSF1Alternative name(s):
IL-12ACytotoxic lymphocyte maturation factor 35 kDa subunit
CLMF p35
IL-12 subunit p35
NK cell stimulatory factor chain 1
- RS2243123 (IL12A) ??
- RS6441286 (IL12A) ??
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Top Gene-Substance Interactions
IL12A Interacts with These Diseases
| Disease | Score |
Substances That Increase IL12A
| Substances | Interaction | Organism | Category |
Substances That Decrease IL12A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Amoebiasis
- Toxoplasmosis
- African trypanosomiasis
- Jak-STAT signaling pathway
- Malaria
- Chagas disease (American trypanosomiasis)
- Allograft rejection
- Type I diabetes mellitus
- Measles
- Toll-like receptor signaling pathway
- Tuberculosis
- RIG-I-like receptor signaling pathway
- Cytokine-cytokine receptor interaction
- Leishmaniasis
Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.
Molecular Function:
- Interleukin-12 Receptor Binding
- Interleukin-12 Beta Subunit Binding
- Interleukin-27 Binding
- Protein Heterodimerization Activity
Biological Processes:
- Positive Regulation Of T Cell Mediated Cytotoxicity
- Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
- Immune Response
- Cell Cycle Arrest
- Response To Virus
- Response To Uv-B
- Response To Lipopolysaccharide
- Negative Regulation Of Interleukin-17 Production
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Natural Killer Cell Activation
- Positive Regulation Of Mononuclear Cell Proliferation
- Positive Regulation Of Smooth Muscle Cell Apoptotic Process
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
- Defense Response To Protozoan
- Positive Regulation Of T Cell Differentiation
- Positive Regulation Of Cell Adhesion
- Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Lymphocyte Proliferation
- Defense Response To Gram-Positive Bacterium
- Positive Regulation Of Nk T Cell Activation
- Cellular Response To Lipopolysaccharide
- Extrinsic Apoptotic Signaling Pathway
- Cellular Response To Virus
- Positive Regulation Of Dendritic Cell Chemotaxis