Summary of GPBAR1
This gene encodes a protein that is a receptor for bile acids called TGR5 (R).
The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids (R).
One effect of this receptor is to convert the inactive thyroid hormone T4 to the active hormone T3.
Diseases associated with GPBAR1 include Sclerosing Cholangitis and Functional Diarrhea.
The Function of GPBAR1
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
Protein names
Recommended name:
G-protein coupled bile acid receptor 1Short name:
BG37Alternative name(s):
G-protein coupled receptor GPCR19hGPCR19
Membrane-type receptor for bile acids
M-BAR
hBG37
- RS11677953 (GPBAR1) ??
- RS3731859 (GPBAR1) ??
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Top Gene-Substance Interactions
Substances That Increase GPBAR1
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Substances That Decrease GPBAR1
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.